Predictors of Quality of Life in Women with Premature Ovarian Insufficiency

Background: Women with premature ovarian insufficiency (POI) have more difficulty concerning their physical and psychological health, indicating a need to provide adequate psychosocial and clinical support for these women to minimize the repercussion of this diagnosis on their activities and quality of life. Objective: To determine the predictors of quality of life in women with premature ovarian insufficiency (POI). Methods: This cross-sectional study was performed on 130 women with POI in Tabriz in 2021 by convenience sampling. Data were collected using the socio-demographic characteristics questionnaire, Spielberger state-trait anxiety inventory (STAI), Beck depression scale (BDI), female sexual function index (FSFI), and the World Health Organization quality of life questionnaire (WHOQOL). The adjusted general linear model was used to estimate the impact and determine the relationship between independent variables (socio-demographic characteristics, anxiety, depression, and sexual function) and dependent variables (quality of life and its domains). Results: The mean total score of quality of life was 46.3 (SD: 18.3) out of 0 to 100. The lowest mean score belonged to the social relations domain (35.6 (17.0)), and the highest mean score belonged to the physical health domain (40.0 (16.0)). Sexual function was one of the predictors of overall quality of life score, and all its domains except environmental health. Depression was one of the predictors of psychological health. Education was also a predictor of psychological and environmental health. Conclusion: Sexual function and mental health are directly related to the quality of life of women with POI.