Polycystic Ovary Syndrome Affects Age-associated Health-Related Quality of Life Among Young Age Women in the Urban-Rural Population

Background: Polycystic ovary syndrome (PCOS) is the major endocrine disorder in women that promptly affects psychological perception and associated social and cultural relations with women. Health-related quality of life (HRQOL) was assessed to explore the effects of PCOS in terms of emotional aspects and related anxiety in women. Objective: The purpose of this study was to explore the psychological burden in adolescent women due to PCOS. Methods: A prospective questionnaire-based study was conducted at a tertiary care hospital, and 100 PCOS and 200 healthy cases were enrolled based on Rotterdam criteria during the year 2017 and 2018. Pre-validated HRQOL questionnaires like Short Form Health survey-36 (SF-36) were used for evaluating the impact of PCOS in women. Results: In PCOS cases, mean age and body mass index was 22.81±5.33 and 24.35±5.49 respectively. A significant difference (P=0.001) regarding age was observed between PCOS and healthy control. The higher percentage of PCOS cases (90 %) were among the category of less than 5 years of PCOS symptoms. In addition, we observed a significant (P=0.001) reduction in quality of life in all eight domains of SF-36 questionnaire between PCOS and healthy control cases. Moreover, a decreasing pattern of SF-36 score was observed with an increase in the duration of PCOS symptoms. Conclusion: Altogether, our result of this study concluded that HRQOL especially emotional changes were more affected in adolescent and middle age group patients that may be due to fear of infertility and cosmetic problems.