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2000
Volume 21, Issue 4
  • ISSN: 1573-4048
  • E-ISSN: 1875-6581

Abstract

Background and Objective

Cervical erosion () is one of the most frequent gynecological conditions seen in clinical practice. Therefore, the objective of the current study was to assess the impact of the topical application of in .

Material and Method

A randomized comparative clinical study was carried out at the Institute Hospital in Bengaluru. Diagnosed cases (n=40) of cervical erosion were randomly assigned to test (n=20) and control (n=20) groups. A total of 6 g ointment of (test drug) and tested Unani formulation (control drug) was applied with an applicator per vaginum over the eroded area of the cervix daily once at bedtime for 14 days. A single dose of the antibiotic regimen (azithromycin-1g and cefixime-400 mg) was administered orally in both groups. Subjective parameters like vaginal discharge, pruritus vulvae, low back ache, lower abdominal pain, and postcoital bleeding were assessed during the trial. The main outcome measure was an improvement in the cervical erosion grading score. The inference was executed with appropriate statistical analysis.

Results

Improvement in the cervical erosion grading score was achieved in 50% and 40% of patients in the control and test groups, respectively, after 2 weeks of treatment with <0.0001, which was considered highly significant. A highly significant improvement in subjective parameters was observed during the trial with <0.0001.

Conclusion

Considering the high prevalence of cervical erosion among women of reproductive age group, effective treatment and safe strategies are highly recommended. is cost-effective and has several therapeutic actions that can help to promote the healing of erosion and relieve the associated symptoms.

Clinical Trial Registration

The clinical trial was registered at the Clinical Trial Registry of India (CTRI) with registration number CTRI/2022/02/040419.

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References

  1. WrightK. MohammedA. OlatunjiS.O. KuyinuY. Cervical ectropion and intra-uterine contraceptive device (IUCD): A five-year retrospective study of family planning clients of a tertiary health institution in Lagos Nigeria.BMC Res. Notes20147194610.1186/1756‑0500‑7‑946 25539789
    [Google Scholar]
  2. GupthaS.C. Evaluation of cervical erosion in symptomatic women.Int. J. Reprod. Contracept. Obstet. Gynecol.2020952035204210.18203/2320‑1770.ijrcog20201801
    [Google Scholar]
  3. SoaresL.C. BrazF.L.T.A. AraújoA.R. OliveiraM.A.P. Association of sexually transmitted diseases with cervical ectopy: A systematic review.Sex. Transm. Dis.201946745245710.1097/OLQ.0000000000000992 30913163
    [Google Scholar]
  4. VenkateshK.K. Cu-UvinS. Assessing the relationship between cervical ectopy and HIV susceptibility: Implications for HIV prevention in women.Am. J. Reprod. Immunol.201369S1687310.1111/aji.12029 23057756
    [Google Scholar]
  5. FahadT. ShameemI. Effectiveness of an unani formulation as topical medication in cervical ectopy-An open observational study.Int J Gen Med Surg2022613310.31531/2581‑8287.1000133
    [Google Scholar]
  6. KumarP. MalhotraN. Jeffcoate’s Principles of Gynecology.7th Ed. New Delhi: Jaypee Brothers Medical Pubishers (P) Ltd2008410411
    [Google Scholar]
  7. AggarwalP. Ben AmorA. Cervical ectropion. In: Stat Pearls.Treasure Island, (FL)Stat Pearls Publishing2020
    [Google Scholar]
  8. CaseyP.M. LongM.E. MarnachM.L. Abnormal cervical appearance: What to do, when to worry?Mayo Clin. Proc.201186214715110.4065/mcp.2010.0512
    [Google Scholar]
  9. RupaparaA. DongaS. LaxmipriyaD. Efficacy of an ayurvedic formulation in the management of primitive cervical cell pathology: An open label clinical trial.Anc. Sci. Life201837314815210.4103/asl.ASL_89_17
    [Google Scholar]
  10. BrightP.L. TurnerN.A. MorrisonC.S. Hormonal contraception and area of cervical ectopy: A longitudinal assessment.Contraception201184551251910.1016/j.contraception.2011.02.002 22018127
    [Google Scholar]
  11. JindalM. KaurS. SharmaS. GuptaK. PandotraP. BhavnaB. What is better: Cryocautery or electrocautery for cervical erosion?Int. J. Reprod. Contracept. Obstet. Gynecol.20143371571910.5455/2320‑1770.ijrcog20140973
    [Google Scholar]
  12. KatoleU. DewaikarS. KuwarR. ChindheP. Colposcopic observations of cervical erosion with application of karanja kalka.WJPR20201011222123310.20959/wjpr20211‑19430
    [Google Scholar]
  13. GautamA. RajanS. SharmaE. A clinical study of kusthadi varti in karnini yonivyapada W.S.R. to cervical erosion.IJCR20179126214062143
    [Google Scholar]
  14. FernandesS.M.S. RibaltaJ.C.L. SpeckN.M.G. YamamuraY. Treatment of uterine cervical ectopy with acupuncture and analysis of risk factors in the metaplastic process.Clin. Exp. Obstet. Gynecol.201946460160510.12891/ceog4807.2019
    [Google Scholar]
  15. MishraM. BagadeT. Review of management of cervical ectropion using traditional ayurvedic interventions.J. Ayurveda Integr. Med.202383556210.21760/jaims.8.3.10
    [Google Scholar]
  16. SurendranN. PatelA.K. Ayurvedic management of cervical erosion through ksharakarma-A review.IJSRT2020511641
    [Google Scholar]
  17. ShivannaD.B.S. ShivannaL. KulkarniP. Comparative study of efficacy of cryosurgery and Albothyl® solution in the management of cervical erosion in a rural hospital.IOSR J. Dent. Med. Sci.201413910610910.9790/0853‑1396106109
    [Google Scholar]
  18. MachadoJunior L.C. DalmasoA.S.W. CarvalhoH.B. Evidence for benefits from treating cervical ectopy: Literature review.Sao Paulo Med. J.2008126213213910.1590/S1516‑31802008000200014 18553039
    [Google Scholar]
  19. NavruzovalN.O. KarshiyevaE.E. GulchekhraA. IkhtiyarovaG.A. HikmatovaN.I. OlimovaN.I. Clinical and laboratory markers forecasting of cervical diseases and its prevention.Annals RSCB20212541309813110
    [Google Scholar]
  20. AchawalS. DeshpandeA. Colposcopic findings in patients of cervical erosion at tertiary center.Sch J Appl Med Sci202210223123410.36347/sjams.2022.v10i02.015
    [Google Scholar]
  21. MajoosiA.I.A. Kamilus Sana. New Delhi. Idarae Kitabul Shifa Jan2010497538
    [Google Scholar]
  22. Sina Ibn Al Qanoon Fil-Tibb.New DelhiIdarae Kitabul Shifa2010125126, 1092
    [Google Scholar]
  23. KhanA. Al Akseer.1st edNew DelhiIdarae Kitabul Shifa2011788790
    [Google Scholar]
  24. KupchakI. GenykN. Combination therapy of uterine cervical ectopy in young nulliparous women.Pharma Innov J2015484144
    [Google Scholar]
  25. AgahJ. SharifzadehM. HosseinzadehA. Cryotherapy as a method for relieving symptoms of cervical ectopy. A randomized clinical trial.Oman Med. J.201934432232610.5001/omj.2019.63 31360321
    [Google Scholar]
  26. SrinivasV.T. ShirkeA. Management of garbhasaya greevagata vrana (Cervical Ectopy) with tankana jala yoni dhavana and aswattha churna orally (Under VIA and VILI).Int J Ayur Med2017811724
    [Google Scholar]
  27. PerkinsR.B. GuidoR.S. CastleP.E. 2019 ASCCP risk-based management consensus guidelines for abnormal cervical cancer screening tests and cancer precursors.J. Low. Genit. Tract Dis.202024210213110.1097/LGT.0000000000000525 32243307
    [Google Scholar]
  28. Standard treatment guidelines (Non respiratory infectious medical conditions).New Delhi: Ministry of health and family welfare. Govt. of India200818
    [Google Scholar]
  29. National Formulary of Unani Medicine Part I.New DelhiCCRUM2006161
    [Google Scholar]
  30. Yaseen KhanM. AliS.A. PundarikakshuduK. Wound healing activity of extracts derived from Shorea robusta resin.Pharm. Biol.201654354254810.3109/13880209.2015.1052886 26030465
    [Google Scholar]
  31. KaushikD. KumarA. KaushikP. RanaA.C. Analgesic and anti-inflammatory activity of Pinus roxburghii Sarg.Adv. Pharmacol. Sci.201220121610.1155/2012/245431 22761611
    [Google Scholar]
  32. ShalliF.G. TaufikurohmahT. ApriyosaE. Preliminary studies on antifungal and antibacterial activity of alum as medicine preparation for vaginal discharge.Int J Res Granthaalayah202098188195
    [Google Scholar]
  33. KumarV. ThakurA.K. BarothiaN.D. ChatterjeeS.S. Therapeutic potentials of Brassica juncea: An overview.Cell Med.2011112110.5677/tang.2011.0005
    [Google Scholar]
  34. PachiV.K. MikropoulouE.V. GkiouvetidisP. Traditional uses, phytochemistry and pharmacology of Chios mastic gum (Pistacia lentiscus var. Chia, Anacardiaceae): A review.J. Ethnopharmacol.202025411248510.1016/j.jep.2019.112485 32092498
    [Google Scholar]
  35. HuangS. ChenX. YanR. HuangM. ChenD. Isolation, identification and antibacterial mechanism of the main antibacterial component from pickled and dried mustard (Brassica juncea Coss. Var. foliosa Bailey).Molecules2022278241810.3390/molecules27082418 35458613
    [Google Scholar]
  36. GargN. Clinical study of tranexamic acid in treatment of cervical ectopy. An institutional experience.Gynecol. Obstet. 202010552510.35248/2161‑10932.2020.10.525
    [Google Scholar]
  37. RaoN.S. Applied statistics in health sciences.New DelhiJaypee Brothers Publishers2010117118
    [Google Scholar]
  38. PereiraM.P. StänderS. Measurement tools for chronic pruritus: Assessment of the symptom and the associated burden: A review.Itch 201944e2910.1097/itx.0000000000000029
    [Google Scholar]
  39. Escalona-MarfilC. CodaA. Ruiz-MorenoJ. Riu-GispertL.M. GironèsX. Validation of an electronic visual analog scale mHealth tool for acute pain assessment: Prospective cross-sectional study.J. Med. Internet Res.2020222e1346810.2196/13468 32049063
    [Google Scholar]
  40. HaefeliM. ElferingA. Pain assessment.Eur. Spine J.200615S1S17S2410.1007/s00586‑005‑1044‑x 16320034
    [Google Scholar]
  41. LiuY. YangK.H. WuT. Microwave therapy for cervical ectropion.Cochrane Libr.2007201011CD00622710.1002/14651858.CD006227.pub2 17943899
    [Google Scholar]
  42. RiffenburghR.H. GillenD.L. Statistics in Medicine.3rd edUSAAcademic press20202021
    [Google Scholar]
  43. DahiruT. P-Value, a true test of statistical significance? a cautionary note.Ann. Ib. Postgrad. Med.201161212610.4314/aipm.v6i1.64038 25161440
    [Google Scholar]
  44. IBM SPSS version 29. www.ibm.com/support/pages/downloading-ibm-spss-statistics-29(Accessed on: 25.08.23).
  45. GuptaP. SharmaS. Clinical evaluation of the efficacy of kshara karma with Apamarga kshara and Jatyadi taila pichu in the Management of Cervical Erosion (Karnini Yonivyapada).WJCPMT201514349
    [Google Scholar]
  46. AneesS. MustafaS. Clinical study for the efficacy of Unani formulation in the Management of Vaginal Discharge Associated with cervicitis (Iltehab-E-Unqur Rehm).IABCR201734127129
    [Google Scholar]
  47. ÇekmezY. ŞanlıkanF. GöçmenA. VuralA. TürkmenS.B. Is cryotherapy friend or foe for symptomatic cervical ectopy?Med. Princ. Pract.201625181110.1159/000441433 26436550
    [Google Scholar]
  48. UsmaniM.I. Tanqeehul Mufradat. 1st ed.. New Delhi: Famous offset press2008711301
    [Google Scholar]
  49. ChopraR.N. NayarS.L. ChopraI.C. Glossary of Indian Medicinal Plants. 6 th ed. New Delhi: NISCIR 200975,19395,226
    [Google Scholar]
  50. Anonymous The Ayurvedic Pharmacopoeia of India Part 1.Ministry of Health and Family Welfare2001191196
    [Google Scholar]
  51. BaghdadiH.I. Kitab Al - Mukhtarat Fi – Al Tib. Vol II. New DelhiCCRUM2005
    [Google Scholar]
  52. HashmiS. BegumW. SultanaA. Efficacy of Sphaeranthus indicus and cream of Lawsonia inermis in cervical erosion with cervicitis.Eur. J. Integr. Med.201133e183e18810.1016/j.eujim.2011.08.002
    [Google Scholar]
  53. ZahidS. RehmanH. RazaA. KousarF. Effect of unani formulation in cervicitis (Warme-unqur-rahm): A single-blind randomized placebo-controlled trial.Altern. Integr. Med.20165121310.4172/2327‑5162.1000213
    [Google Scholar]
  54. PrajapatiN.D. PurohitS.S. SharmaA.K. KumarT. A handbook of medicinal plants: A complete source book.Jodhpur, RajasthanAgrobios2009
    [Google Scholar]
  55. HakimH.M.A. Bustanul Mufradat Part I. New Delhi.Idarae Kitabul Shifa200293290291
    [Google Scholar]
  56. KabeeruddinH. Makhzanul Mufaradat. New Delhi.Idarae Kitabul Shifa2007118141142
    [Google Scholar]
  57. KhanM.A. Muhit-i-Azam.New DelhiCCRUM2013615620
    [Google Scholar]
  58. AnsariS. BegumW. FirdoseK.F. Efficacy of Unani Formulation in Cervical Ectopy (Quruhal Rahim) - An Open Observational Study.Int. J. Curr. Res. Rev.2021133334210.31782/IJCRR.2021.13314
    [Google Scholar]
  59. AitahN.H.A. HamoudaM.L. AhmedA. ElsokaryA.E. Evaluation of autologus platelet-rich plasma versus silver nitrate in the treatment of cervical erosion.Tanta Med. J.20214927910.4103/tmj.tmj_162_20
    [Google Scholar]
  60. GhaniH.N. Khazainul Adviya.New DelhiIdarae Kitabul Shifa2010287288
    [Google Scholar]
  61. Anonymous Standardisation of Single Drugs of Unani Medicine Part III.New DelhiCCRUM1997256260
    [Google Scholar]
  62. NadkarniK.M. Indian Materia Medica. 3rd ed.. Mumbai: Popular Prakashan (P)Ltd 2009
    [Google Scholar]
  63. SharmaP. SharmaS. A clinical study to evaluate efficacy of Snuhi kshara and dhatakyadi tail pichu in the management of Karnini Yonivyapad wsr to cervical erosion.WJPR201541012581265
    [Google Scholar]
  64. YadavD. SinghS. DhawanB. SoodS. GuptaS. Laboratory detection of bacterial pathogens and clinical laboratory response of syndromic management in patients with cervical discharge: A retrospective study. Indian J Dermatol Venereol Leprol 2023; 89:431-5.Indian J. Dermatol. Venereol. Leprol.202150610.25259/IJDVL
    [Google Scholar]
  65. ChoukseyM SolankiSK ShankarP DaveHH A brief review of research studies conducted on kshara karma in the management of cervical erosion (Karnini Yonivyapad). WJPR 202091410.20959/wjpr202014‑19004
    [Google Scholar]
  66. MishraA.K. KrishnapriyaN.V.R. N v R. Therapeutic uses of bees wax in Ayurveda and its physicochemical analyses: A Review.Int. J. Res. Ayurveda Pharm.201781252610.7897/2277‑4343.08131
    [Google Scholar]
  67. Bogdanov S. Beeswax. Switzerland: Beeswax book 2016
    [Google Scholar]
  68. AliA. Shibb-i-Yamani (alum) a unique drug and its utilization in Unani Medicine: A Physicochemical and pharmacological review.Int. J. Res. Ayurveda Pharm.201782172210.7897/2277‑4343.08255
    [Google Scholar]
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