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Neutrophil Elastase as A Potential Target in Ischemia-Reperfusion Injury
Authors: Yiqing Tan and Wei ZuoAvailable online: 13 January 2025More LessNeutrophil elastase (NE), a major protease in neutrophils, is important in promoting inflammation and multiple pathological processes. While NE is released abundantly in ischemia-reperfusion (I/R) injury, the intricate relationship between NE and I/R injury remains unclear. We examine several aspects of how NE is involved in I/R injury. We also discuss the possibility of NE inhibitors used for abbreviating various types of I/R injury, Read More
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Sodium Glucose Cotransporter-2 Inhibitors Improve Endothelial Function and Arterial Stiffness in Diabetic Individuals: A Systematic Review and Network Meta-Analysis
Authors: Kannan Sridharan and Gowri SivaramakrishnanAvailable online: 06 January 2025More LessIntroduction Sodium Glucose cotransporter-2 inhibitors (SGLT2is) possess pleiotropic effects, such as antioxidant, antifibrotic, anti-inflammatory, and vascular remodeling activities. Considering the lack of literature, a network meta-analysis was conducted to explore the impact of SGLT2is on endothelial dysfunction and arterial stiffness in the diabetic population. Methods Electronic databases were searched to identify randomi Read More
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