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- Volume 5, Issue 2, 2010
Current Signal Transduction Therapy - Volume 5, Issue 2, 2010
Volume 5, Issue 2, 2010
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Current Strategies to Improve the Efficacy and the Delivery of Nucleic Acid Based Drugs
Authors: M. Grassi, G. Cavallaro, S. Scire, B. Scaggiante, B. Dapas, R. Farra, D. Baiz, C. Giansante, G. Guarnieri, D. Perin and G. GrassiThe limited efficacy of current therapeutic approaches for a number of socially relevant human diseases has required the exploration of alternative and more effective therapeutic strategies. In the last three decades, nucleic acid based drugs (NABDs) have emerged as an attractive and novel alternative with great therapeutic potential. NABDs which include antisense oligonucleotides, decoys, aptamers, triple helix forming oligo Read More
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Secreted Heat Shock Protein-90α: A More Effective and Safer Target for Anti-Cancer Drugs?
Authors: Chieh-Fang Cheng, Jianhua Fan, Zhengwei Zhao, David T. Woodley and Wei LiUntil recently, heat shock protein 90 (Hsp90) has been mostly known as an abundant intracellular chaperone with more than 100 target proteins often involved in control of cell metabolism, survival, growth and differentiation. Hsp90 has been a target for anti-cancer drugs, since it was found either overexpressed or overactive in cancer cells. For more than a decade, geldanamycin (GM)-derived inhibitors of Hsp90's ATPase ha Read More
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Presenilin and γ -Secretase Activity: A Viable Therapeutic Target for Alzheimer's Disease?
Authors: Run Yan and Justin V. McCarthyIn this review, we discuss the γ-secretase protease complexes, which are responsible for the generation of amyloid-β peptides that constitutes the amyloid plaques of Alzheimer's disease (AD). We begin with a brief review on the amyloid-β precursor protein (APP), its proteolytic cleavage and a brief discussion on the pathogenesis of AD. We then present the four major components of the γ-secretase complexes - presenilin, nicas Read More
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Mevalonate-Ras Homology (Rho)/Rho-Associated Coiled-Coil-Forming Protein Kinase (ROCK)-Mediated Signaling Pathway as a Therapeutic Target for the Treatment of Endometriosis-Associated Fibrosis
Authors: Kaei Nasu, Akitoshi Tsuno, Akitoshi Yuge and Hisashi NaraharaEndometriosis, a disease affecting 3-10% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue. Histologically, this disease is characterized by endometrial gland and stroma with surrounding dense fibrous tissue. During the development of endometriotic lesions, excess fibrosis may lead to scarring and to alteration of the tissue function. It has been suggested that type I colla Read More
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Concepts of Egr-1 Activation - A Hub for Signal Transduction Cascades
Authors: Judith-Irina Pagel and Elisabeth DeindlThe early growth response-1 (Egr-1) gene encodes a Cys2-His2-type zinc-finger transcription factor. A broad range of extra cellular stimuli are known to lead to its induction thus furthering growth, proliferation, differentiation or apoptosis. Accordingly, Egr-1 is involved in a variety of diseases such as atherosclerosis or cancer. Among other functional elements, five serum response elements (SRE) have been identified in the pr Read More
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Signal Transduction of Steroidogenic Hormones to the Adrenal and Gonadal Mitochondria and the Possibilities for Combating Lipoid Congenital Adrenal Hyperplasia
More LessIn steroidogenic tissue the first and rate limiting step of steroid hormone synthesis is the transport of cholesterol from the outer mitochondrial membrane to the inner membrane where it is enzymatically converted by cytochrome P450 side chain cleavage (P450scc) to pregnenolone, which is the metabolic precursor for all steroid hormones. This step is accelerated by steroidogenic hormones but how the signal from the peri Read More
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The ErbB Receptors and Their Ligands in PKD, an Overview
Authors: Fenghua Zeng and Raymond C. HarrisPolycystic kidney diseases (PKDs) represent a group of progressive genetic renal disorders that are characterized by the development of renal cysts that lead to end-stage renal disease. The rapid advance in our understanding of the pathogenesis of PKDs is revealing possible targets to slow down the progression of PKD. Among them, the epidermal growth factor receptor (EGFR) family members (ErbBs) as well as their ligands, suc Read More
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Oxidative Stress-Induced Caspases are Regulated in Human Myeloid HL-60 Cells by Calcium Signal
Authors: D. Gonzalez, I. Bejarano, C. Barriga, A.B. Rodriguez and J.A. ParienteThe present study is aimed to determine the role of Ca2+ signaling evoked by hydrogen peroxide (H2O2) on caspase activation in human leukemia cell line HL-60. We have analysed cytosolic free Ca2+ concentration ([Ca2+]c) determination, mitochondrial membrane potential and caspase-3 and -9 activity by fluorimetric methods, using the fluorescent ratiometric Ca2+ indicator Fura-2, the dye JC-1, and specific fluorogenic su Read More
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Volumes & issues
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Volume 20 (2025)
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Volume 19 (2024)
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Volume 18 (2023)
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Volume 17 (2022)
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Volume 16 (2021)
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Volume 15 (2020)
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Volume 14 (2019)
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Volume 13 (2018)
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Volume 12 (2017)
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Volume 11 (2016)
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Volume 10 (2015)
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Volume 9 (2014)
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Volume 8 (2013)
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Volume 7 (2012)
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Volume 6 (2011)
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Volume 5 (2010)
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Volume 4 (2009)
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Volume 3 (2008)
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Volume 2 (2007)
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Volume 1 (2006)
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