Current Signal Transduction Therapy - Volume 16, Issue 3, 2021

It was 11 March 2020 when the World Health Organization (WHO) declared the name COVID-19 for coronavirus disease and also described it as a pandemic. Till that day 118,000 cases were confirmed of pneumonia with breathing problem throughout the world. At the start of New Year when COVID-19 came into knowledge a few days later, the gene sequencing of the virus was revealed. Today the number of confirmed cases i Read More

Till now, across from a few basic data, nothing is well clear regarding its exact origin, incubation period, seriousness and what makes it transmissible is not recommended for COVID19 anywhere in the world. It was on 28 January, 2020 that the World Health Organisation released a paper relating to medical data and recommendations from the management of previous HCoV epidemics. The present paper outlines st Read More

The world is connected by the internet. It is very useful because we use Google to find out any new topic, to search for new places, to quest updated research, and to get knowledge for learning. People around the world can communicate with each other through the Google video conference talk. Internet is frequently used in smartphones, laptops, desktops, and tablets. Excessive affinity towards internet-based onli Read More

This article provides a comprehensive review of the recent trends and applications of BCIs. This review also provides future directions towards the acceleration and maturation of BCI technology. Based on a methodical search strategy, major technical databases were searched in quest of research papers of average and outstanding interest. A total of 188 research works were included within this review due to their suitabili Read More

Background: The circular RNAs (circRNAs) are defined as single-stranded RNA molecules with a length of 100 bp up to 4 kb, resulting from head-to-tail junctions at splice sites of spliced transcripts. Moreover, they are stable and abundant conserved RNA molecules, which often have tissue-specific expression and developmental stages. Dysregulation of circRNAs has been identified in many types of malignancies that mainly Read More

An infectious disease emerged from Wuhan, China, in December 2019 and then spread to many countries worldwide. Initially, it was named Coronavirus disease 2019, and then it was called COVID-19. COVID-19 is an ongoing pandemic with 60.2 million confirmed cases and a leading health concern for the public worldwide. Mainly middle and old-aged people are being hospitalized and are dying across the affected co Read More

Background: The paper aims to review existing solutions for smart building to increase hospitality levels in locations like hospitals. The answers could support features such as online appointments, smart navigation, and queue management in the building through mobile phone and navigation to the desired location by highlighting the point of interest and facilities and checking the spaces' occupancy. Methods: Such a Read More

All over the world, there is a new target of public health emergency looming the world along with an appearance and distribution of the novel coronavirus disease (2019-nCoV) also known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This Virus was initially generated in bats and then transferred to a human being over an unknown animal playing the role of a mediator in Wuhan, China, in December 20 Read More

Background and Objective: The advent of Next Generation Sequencing (NGS) has created a high throughput platform to identify disease traits and phenotypic characteristics using RNASeq Sequencing analysis in humans. Non-small cell lung cancer (NSCLC), a lethal disease, accounts for 85 percent of most lung cancers with a very small window of survival rate. The decision of tumour image biomarker impression can be imp Read More

Introduction: In this paper, a robust sliding mode controller is developed to control an orthosis used for rehabilitation of lower limb. Materials and Methods: The orthosis is defined as a mechanical device intended to physically assist a human subject for the realization of his movements. It should be adapted to the human morphology, interacting in harmony with its movements, and providing the necessary efforts along wit Read More

Background: As the outbreak of COVID-19 has accelerated, an urgent need for finding strategies to combat the virus is growing. Thus, gaining more knowledge on the pathogenicity mechanism of SARS-CoV-2, i.e. the causing agent of COVID-19, and its interaction with the immune system is of utmost importance. Although this novel virus is not well known yet, its structural and genetic similarity with SARS-CoV as well as the c Read More

Background: PARK9 familial Parkinson’s disease (PD) is caused by a loss-of-function mutation in the ATP13A2 gene in which the mutation impairs the autophagic-lysosomal degradation pathway and induces intraneuronal accumulation of alpha-synuclein. RNA interference has been a useful tool in generating in vitro knockdown model to study the physiological role of the gene. However, the availability of a validated ATP13A2- Read More