Current Signal Transduction Therapy - Volume 13, Issue 2, 2018

Background: Signal transduction is a process where a chemical or physical signal is transmitted from extracellular to the intracellular nuclear matrix as a series of molecular events, most commonly protein phosphorylation which ultimately result in a response. At the molecular level, such responses include changes in the transcription or translation of genes, and posttranslational and conformational changes in proteins, as Read More

Background: Complex integrin molecules, composed of eighteen α and eight β subunits, are responsible for modulating different signal transduction mechanisms across the plasma membrane. Two heterodimeric integrins, α4β7 and α4β1 are in the interest of researchers due to their immense importance in regulating a variety of inflammatory diseases such as asthma, rheumatoid arthritis (RA), inflammatory bowel disease (IBD Read More

Background: Parkinson's disease commonly characterised as a neurodegenerative disease affecting the global population in the upper age limit affecting movement and is identified by stopped posture, shaking hands and frequent tremors. The difficulty in the treatment of the disease arises due to the fact that a considerable time lag exists between the onset of the disease internally and appearance of the disease symptoms. Read More

Background: Cancer is a complicated genetic disorder which is a major global health issue. The complexities of several cancer therapies are due to heterogenic nature of tumor and its microenvironment that is highly inflammatory and acidic. Thus, cancer related inflammation (CRI) is responsible for metastasis, resistance and recurrence of cancer. Although, several researches are being investigated, still emphasis is b Read More

Crossing the threshold in clinical activity, chimeric antigen receptor-modified T cells have emerged as a new effective therapeutic regimen against various types of cancer both in adults and pediatric oncology. Currently available CARs are designed in a manner so that that they are capable of recognizing MHC independent antigen and incorporate costimulatory signal, converting the transduced T cells with potent activity. They Read More

Background: The whole thought is to demonstrate the parallel parking framework for self-ruling robots with the help of real-time embedded boards. Autonomous systems are outlined and developed by considering the non-holonomic requirements. PID controller is used to accomplish the servo reaction. The path planning scheme is created for parallel stopping of self-ruling vehicles by gaining data from the sensor. Methods: The Read More

Background: Since surface electromyogram (SEMG) signal plays a vital role in prosthetic designs, hence the evaluation of these signals for identifying the upper arm motions leading to myoelectric control based design of artificial devices is presented. Methods: A total of two upper limb locations were chosen for recording of data, thereafter the evaluation and interpretation of signal was done for the estimation of extrac Read More