Current Signal Transduction Therapy - Volume 11, Issue 1, 2016

The mechanism for the chemoresistance of cancer cells is quite complicated. Most of the anti-cancer drugs are known to induce apoptosis in cancer cells, as well as in normal cells, in part by the activation of the p53 pathway. p53 is often referred to as the 'guardian of the genome' and is one of the most investigated tumor suppressor genes. A majority of human tumors harbor p53 mutations which can influence the effect Read More

Pancreatic cancer is one of the most lethal cancers and leading cause of cancer related death worldwide. Due to its nonspecific early symptoms, pancreatic cancer is difficult to diagnose before extensive local invasion and distant metastasis. The 5-year survival rate of patients diagnosed with pancreatic cancer is less than 5%. Their median survival time is less than 12 months. The molecular mechanisms of pancreatic tumor g Read More

As a pathological product of bovine gallbladder, natural Calculus Bovis (CB) has a long history in Traditional Chinese Medicine to treat many diseases such as: stroke,coma, delirium, epilepsy, encephalitis B, etc. Experimental studies showed that natural CB had effects on central nervous system, cardiovascular system, inflammation, etc. Recent analyses confirmed that bilirubin composed the main proportion of all CB com Read More

Biliary and pancreatic lithiasis are rare complications in postpancreaticoduodenectomy (PD) patients, the possible risk factors and treatment strategies remain unclear. In this study, medical records of patients who underwent PD procedure from 2003 to 2013 in Qilu hospital, Shandong University in China were reviewed retrospectively. Clinical data were collected and statistically analyzed. We found that bile duct stone or Read More

Background: Chitin and its derivatives participate and influence many important biological activities, such as antibiosis, modulating immunity, suppressing tumor growth, and promoting wound healing as well as promoting hemostasis. This study aimed at confirming the effects of water-soluble chitosan (ws-chitosan) on accelerating healing of induced fractures in New Zealand white rabbits. Materials and methods: Thirty- Read More

Celiac disease is one of the most frequent diseases genetically determined, with vast and heterogeneous series of clinical manifestations, interests all ages of life. A gliadin peptide, P31-43, is being able to induce an immune response in patients with CD, mainly by means of IL15 and IL15Ralpha activation has been identified. Recently, 30 genes were identified in the small bowel which are able to control the epithelial cell differenti Read More

The inhibition of scorpion extracts on esophageal cancer and lung adenocarcinoma cells has been reported by previous studies, but the specific anti-tumor efficacy and potential molecular mechanism have not been clarified. In this study, we first modified the optimal enzymolysis and inactivation technology by imitating gastric and intestinal enzyme, and then investigated the antitumor effect of scorpion extracts both i Read More

Trypsin, chymotrypsin and elastase were combined to hydrolyze scorpion Buthus marstesii Karsch powders to prepare scorpion peptides (SP). Orthogonal design experiment L16 (44) was used to optimize variables of enzymolysis temperature, time, pH and enzyme concentration. Degree of hydrolysis (DH) and inhibition rate (IR) of A549 cells were selected as analysis indicators. The optimum enzymolysis conditions were dete Read More

Background: Hyperglycemia is found to be a regulator of HIF-1α gene expression but the regulation of HIF-1α on glucose homeostasis is unclear. Objective: To determine whether chronic intermittent hypoxia (CIH) alters glucose regulation and such alterations can revert through treatments with either antioxidant (vitamin c) or calcium channel blocker (cilnidipine) in male albino rats. Methods: The rats were divided into six gro Read More

The concurrence of different types of brain tumors is extremely rare. We present a 29-yearold women with brainstem hemangioblastoma, posterior fossa meningiomas and a pituitary spaceoccupying lesion causing hyperprolactinemia.Despite multiple primary intracranial tumors,through systemic work-up, no other manifestation related to von Hippel-Lindau(VHL) disease was found. Complete resection of t Read More