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Volume 20, Issue 3
  • ISSN: 1574-888X
  • E-ISSN: 2212-3946

Abstract

Aims

The aim of this study was to investigate the role of human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exo) in regulating the intestinal type 2 immune response for either protection or therapy.

Background

hUCMSC-Exo was considered a novel cell-free therapeutic product that shows promise in the treatment of various diseases. Type 2 immunity is a protective immune response classified as T-helper type 2 (Th2) cells and is associated with helminthic infections and allergic diseases. The effect of hUCMSC-Exo on intestinal type 2 immune response is not clear.

Methods

C57BL/6 mice were used to establish intestinal type 2 immune response by administering of and treated with hUCMSC-Exo before or after infection. Intestinal organoids were isolated and co-cultured with IL-4 and hUCMSC-Exo. Then, we monitored the influence of hUCMSC-Exo on type 2 immune response by checking adult worms, the hyperplasia of tuft and goblet cells.

Results

hUCMSC-Exo significantly delays the colonization of in subserosal layer of duodenum on day 7 post-infection and promotes the hyperplasia of tuft cells and goblet cells on day 14 post-infection. HUCMSC-Exo enhances the expansion of tuft cells in IL-4 treated intestinal organoids, and promotes lytic cell death.

Conclusion

Our study demonstrates hUCMSC-Exo may benefit the host by increasing the tolerance at an early infection stage and then enhancing the intestinal type 2 immune response to impede the helminth during Th2 priming. Our results show hUCMSC-Exo may be a positive regulator of type 2 immune response, suggesting hUCMSC-Exo has a potential therapeutic effect on allergic diseases.

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/content/journals/cscr/10.2174/011574888X314032240429113240
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Human Umbilical Cord Mesenchymal Stem Cell-derived Exosome Regulates Intestinal Type 2 Immunity
Curr Stem Cell Res Ther 20, 302 (2025); https://doi.org/10.2174/011574888X314032240429113240
/content/journals/cscr/10.2174/011574888X314032240429113240
/content/journals/cscr/10.2174/011574888X314032240429113240
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  • Article Type:     Research Article
Keyword(s): exosomes; goblet cell; helminth; IL-4; lytic cell death; organoid; tuft cell; Type 2 immunity; umbilical cord mesenchymal stem cells

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