Current Spectroscopy and Chromatography - Online First

A new method for valsartan (VST) estimation in pharmaceutical dosage samples by spectrophotometry was developed.

The method was based on the formation of coloured dye by the diazotization reaction of 3-amino-2-naphthol with sodium nitrite in an acidic medium to form diazonium compounds, which were then coupled with VST in a basic medium.

The drug sample showed linearity in the range 4.6 - 24.2 μgmL^-1, and the λmax was found at 432nm. Sandell’s sensitivity (9.950×10^-3), Molar absorbtivity (Ɛ= 4.377×10⁴), regression equation (y= 0.0775x + 0.0041), correlation coefficient (r²= 0.968), detection limit (DL= 0.668) and quantitation limit (QL= 2.024) were evaluated.

The percentage recovery of the drug samples was found to be 100%. This method successfully determined VST in Pharmaceutical dosage samples.