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image of Developing a New Method for the Estimation of Valsartan (VST) in Pharmaceutical Dosage Samples by Using Diazotization and Coupling Reactions Spectrophotometrically

Abstract

Introduction

A new method for valsartan (VST) estimation in pharmaceutical dosage samples by spectrophotometry was developed.

Method

The method was based on the formation of coloured dye by the diazotization reaction of 3-amino-2-naphthol with sodium nitrite in an acidic medium to form diazonium compounds, which were then coupled with VST in a basic medium.

Results

The drug sample showed linearity in the range 4.6 - 24.2 μgmL-1, and the λ was found at 432nm. Sandell’s sensitivity (9.950×10-3), Molar absorbtivity (Ɛ= 4.377×104), regression equation (y= 0.0775x + 0.0041), correlation coefficient (r2= 0.968), detection limit (DL= 0.668) and quantitation limit (QL= 2.024) were evaluated.

Conclusion

The percentage recovery of the drug samples was found to be 100%. This method successfully determined VST in Pharmaceutical dosage samples.

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2024-10-24
2025-04-18

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/content/journals/csch/10.2174/0129504910320544241018094320
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Developing a New Method for the Estimation of Valsartan (VST) in Pharmaceutical Dosage Samples by Using Diazotization and Coupling Reactions Spectrophotometrically
Bentham Science Publishers ; https://doi.org/10.2174/0129504910320544241018094320
/content/journals/csch/10.2174/0129504910320544241018094320
/content/journals/csch/10.2174/0129504910320544241018094320
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  • Article Type:     Research Article
Keywords: diazotization ; Valsartan(VST) ; pharmaceutical dosage samples ; spectrophotometry ; 3-amino-2-naphthol
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