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Volume 21, Issue 2
  • ISSN: 1573-398X
  • E-ISSN: 1875-6387

Abstract

Background

Long-term impacts of inhaled corticosteroids (ICSs) on metabolic parameters of asthmatic children are still uncertain.

Objective

This study aimed to evaluate the effects of long-term use of ICSs on metabolic and anthropometric measures among children with asthma in Iran.

Methods

This case-control study was conducted among 200 pediatric asthmatic patients who were referred to Abuzar Hospital (Ahvaz, Iran) during nine months. Demographic and clinical data of the patients were recorded. The participants were categorized into two groups: Group 1 (n = 100) comprising children with moderate to severe asthma, and Group 2 (n = 100) consisting of those with mild asthma.

Results

The average age of 200 patients was 8.1 ± 2.9 years. The majority of them were male. The prevalence of wasting, stunting, obesity, and overweight was higher among Group 1 compared to Group 2 ( < 0.05). Patients in Group 1 had significantly higher levels of calcium, vitamin D, lipids, and glycemic parameters than those in Group 2 ( < 0.05). In addition, the duration of ICS use was notably longer in Group 1 ( < 0.05).

Conclusion

Children with moderate and severe asthma had significantly elevated lipid and glycemic parameters, as well as a higher prevalence of wasting, stunting, obesity, and overweight compared to patients with mild asthma. Further studies involving larger sample sizes and longer durations are necessary to confirm these findings.

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Effects of Long-Term Inhaled Corticosteroid Therapy on Metabolic And Anthropometric Parameters in Pediatric Patients with Asthma
Current Respiratory Medicine Reviews 21, 159 (2025); https://doi.org/10.2174/011573398X321966240816091814
/content/journals/crmr/10.2174/011573398X321966240816091814
/content/journals/crmr/10.2174/011573398X321966240816091814
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  • Article Type:     Research Article
Keyword(s): anthropometric; Asthma; glycemic, ICSs; lipid profile; pediatric patients

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