Current Regenerative Medicine (Discontinued) - Volume 7, Issue 1, 2017

The analytical review is devoted to the current state of the world problem of restoring the anatomical and functional integrity of the spinal cord after trauma in experimental animal models and humans. The review includes the epidemiology and pathophysiology of spinal cord injury (SCI), the use of stem cells for local transplantation in the central nervous system, including embryonic or induced pluripotent stem cells or the pr Read More

The human endometrium is a very dynamic tissue undergoing an extraordinary growth during pregnancy and, in a cyclic manner, during the reproductive life of each woman. Endometrial stem cells (ESCs), undifferentiated auto-renewable cells able to generate daughter cells showing a higher level of differentiation, play a fundamental role in endometrial regeneration and repair. Therefore, they have a great therapeutic Read More

Mesenchymal stem cells (MSCs) are pluripotent stem cells isolated from adipose tissue (AD-MSCs), bone marrow (BM-MSCs) and umbilical cord (UC-MSCs). Due to their ability to differentiate into multiple cell types, homing to injury sites and immunosuppressive properties have been proposed as a promising option in regenerative medicine. Studies have shown that the majority of regenerative effects of MSCs are exerted through Read More

Background: Chondrogenic differentiation of human embryonic stem cells (hESCs) has been investigated by maintenance of 3-dimensional cultures in the presence of various exogenous growth factors added during defined stages of culture, or in cocultures with primary chondrocytes, making the cultivation process rather complex. Thus, there is a need for easier and more handy expansion and differentiation protocols. Objecti Read More