Skip to content
2000
Volume 16, Issue 4
  • ISSN: 2772-4328
  • E-ISSN: 2772-4336

Abstract

Objective: The study was conducted to determine whether synthetic Disease-Modifying Anti Rheumatic Drugs (DMARDs) suppress the latency of Tuberculosis (TB) infection in Rheumatoid Arthritis (RA) patients along with other variables. Methods: This was done through Tuberculin Skin Test (TST) using purified protein derivative (PPD) in a cohort of RA patients. The TST was taken positive when induration post-PPD injection was ≥ 5mm and negative or anergic when it was < 5mm. We included 100 patients (N = 100). Results: The prevalence of positive TST was 36%, while 64% presented a negative result. Negative TST was significantly associated with steroid usage (39.4%, 95% CI: 28.4%-51.4%). Anergic (TST negative) and non-anergic (TST positive) patients were separated into groups, and a new analysis was conducted with elaboration on DMARDs used. Conclusion: The use of steroids was associated with TST negativity, The same is not true with use of methotrexate or other DMARDs. Thus TST should be interpreted with caution, especially before starting biologicals.

Loading

Article metrics loading...

/content/journals/crcep/10.2174/1574884715999201231201538
2021-11-01
2025-07-03
Loading full text...

Full text loading...

/content/journals/crcep/10.2174/1574884715999201231201538
Loading

  • Article Type:
    Research Article
Keyword(s): anergic; DMARD; latent tuberculosis; poly-arthritis; Rheumatoid arthritis; TST
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test