Current Psychiatry Reviews - Volume 12, Issue 3, 2016

Adaptive behavior (AB) is defined as the skills acquired in response to everyday life demands. AB profiles of genetic syndromes have been proposed, but the literature on them has not been conclusive, mainly due to the large number of these syndromes and marked within-profile variability. The aim of the present study was to analyze the different ABs observed in subjects with Williams-Beuren Syndrome (WBS), Do Read More

Previously, it has been demonstrated that the slow wave sleep(SWS) functioned to adjust the emotional balance disrupted by accumulated emotional memories, while the rapid eye movement(REM) sleep played the opposite role. Many observations have demonstrated that the REM sleep processes emotional memories, while often disrupts the emotional balance toward depression, consistent with the conflict of learn Read More

While in current years the association between psychiatry and psychotherapy has turned into a conflicting one, the swing of the pendulum toward biological psychiatry has led, in general, to a downgrading of psychotherapy within the realm of psychiatry. So, the question of whether or not psychiatrists should continue to learn and carry out psychotherapy is now a much discoursed topic in psychiatric groups. Encouragemen Read More

Background: Semi/Structured interview measures of psychotic symptoms are often translated for use in non-English speaking populations. These vary widely in quality and reported psychometric properties. Objective: The evidence for the reliability and validity of translated measures is systematically reviewed using identified quality criteria. Method: Studies were identified through systematic searches of PsychINFO, Med Read More

The neuronal synaptic action potential is still considered the basic unit of signaling in the brain underlying mental states, behavior and psychiatric disorders. However, exponentially deepening and mind boggling progress has been made during the last 30 years in the molecular and cellular understanding of what drives action potentials. The classical “synaptic relay model” of the action potential is now considered to be a spe Read More

Background: Many patients with major depressive disorder (MDD) do not respond adequately to first-line antidepressant treatment (ADT). Adjunctive treatment with second-generation antipsychotics has demonstrated efficacy for patients with MDD, but is limited by tolerability and safety issues. The recently introduced serotonin-dopamine activity modulator, brexpiprazole, has demonstrated efficacy as an adjunctiv Read More

Objective: To summarize efficacy data from two phase 2 and two phase 3 short-term, multicenter, randomized, double-blind, placebo-controlled studies of brexpiprazole adjunctive to antidepressant treatments (ADTs) in patients with major depressive disorder (MDD) with inadequate response to ADTs. Methods: Patients with MDD who were inadequate responders to 1–3 prior ADTs entered an 8-week single-blind prospective trea Read More