Current Psychopharmacology - Volume 11, Issue 1, 2022

Various clinical results are obtained regarding the effects of cerebellar GABA transmission on spinocerebellar ataxias. Based on animal studies, it is proposed that balanced GABAergic transmission between GABA and other neurotransmitters such as glutamate may lead to more promising results in treating such conditions.

A deficit in brain serotonin (5-hydroxytryptamine; 5-HT) is implicated in a number of psychiatric illnesses, including depression. The treatment efficacy of this highly prevalent brain disorder is not adequate largely due to the depletion of serotonin stores. Tryptophan, an essential amino acid, is the sole precursor of serotonin; its systemic or oral administration increases serotonin synthesis because tryptophan hydroxylase, the Read More

Background: Repeated cocaine administration changes histone acetylation and methylation on Lys residues and Deoxyribonucleic acid (DNA) within the nucleus accumbens (NAc). Recently Nestler’s group explored histone Arg (R) methylation in reward processing models. Damez- Werno et al. (2016) reported that during human investigations and animal self-administration experiments, the histone mark protein-R-methyltransfe Read More

Attention deficit hyperactive disorder or ADHD is a common disorder among children, and if not identified early, it may affect the child’s later life. Pharmacotherapy in ADHD has been linked to the emergence of other emotional disorders. Children who get pharmacological treatment are more likely to continue taking these medications until adulthood, increasing their risk of acquiring other psychological problems. As a result, th Read More

Ageing comes with degeneration in many biological activities like impairment of cognition, intelligence, attention, and memory. The decline in all those mental capabilities would be due to the abnormal changes in neuronal architecture with increasing age, chronic oxidative stress, inflammatory state of the tissue, and nutritional deficiency. Nootropics or smart drugs enhance memory, attention, creativity, and cognit Read More

Introduction: The mainstay of pharmacological management of opioid dependence is opioid substitution treatment. Methadone is a long-acting opioid agonist, which is used for detoxification and maintenance of opioid-dependent people. Objective: Objective of the present evaluation included a comparison between methadone and acetaminophen codeine plus clonidine for management of opioid withdrawal symptoms Read More

Background: Psychotropic polypharmacy is particularly common, which puts psychiatric patients at high risk for developing drug-drug interactions. Objective: We aimed to study potential interactions between psychotropic medications prescribed within the outpatient psychiatry setting. Methods: This was an audit study, which targeted a sample of outpatient prescriptions ordered within the outpatient clinics of the main psychiatry Read More

Background: Diabetes mellitus refers to comorbidities associated with reduced release of the brain-derived neurotropic factor and disruption in the metabolism of neurotransmitters leading to depression and cognitive impairment. Allopathic medications are available for the treatment of diabetes, but there is no cure and multiple adverse effects adhere to it. The therapeutic effects of co-administered chamomile with saffr Read More