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Background: Preliminary studies support the clinical effect of acupressure in managing neuropsychiatric diseases. However, procedures for the selection of intervention and Tele-acupressure self-practice implementation techniques are lacking. This lack of information hinders further studies on the effect of Tele-acupressure self-practice and its subsequent clinical uses. Objective: The aim of this study was to assess the effect of Tele-acupressure self-practice on the improvement of mental health as well as depression, anxiety and well-being during COVID-19 in Malaysia. Methods: The goal of this work was to manage Tele-acupressure self-practice for mental health during COVID-19. All the participants (N=80) enrolled in this study were staying at one of the same communities. The participants were randomly allocated to one of the two groups; 40 participants were involved in the Tele-acupressure self-practice group, and 40 participants were involved in the Nonacupressure group. Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, and personal well-being (using the four Office for National Statistics personal well-being questions, ONS-4) were used to assess measurement. Data were collected at baseline and after four weeks of treatment. Results: The Hamilton Depression Rating Scale (6.29±1.65), Hamilton Anxiety Rating Scale (7.20±0.65), anxiety score in well-being ONS-4 (3.34±0.38) were significantly lower; the happiness score in well-being ONS-4 (8.82±0.86) was significantly higher in the Tele-acupressure self-practice group compared with the Non-acupressure group in the after four week’s assessments. The two groups were not statistically different regarding satisfaction with life and sorthwhile in the well-being ONS-4 questionnaires. Conclusions: Tele-acupressure self-practice had an effect than Non-acupressure in participants during COVID-19 pandemic. But, satisfaction with life and worthwhile in the well-being was better in both of the groups, which proved the participants became more relaxed. Tele-acupressure self-practice being used for the COVID-19 pandemic period facilitates the development of Malaysian public mental health intervention.