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Volume 21, Issue 2
  • ISSN: 2666-0822
  • E-ISSN: 2666-0830

Abstract

Introduction

Generalized anxiety disorder (GAD) is characterized by exaggerated anxiety without any apparent cause of concern. The primary treatment of this disorder is usually SSRIs, which have many digestive side effects and do not provide complete treatment for the patient. The use of non-pharmacological methods may help reduce these complications. Therefore, the present study was conducted to investigate the effect of ginger as an adjunctive therapy along with SSRIs to reduce anxiety in patients with GAD.

Materials and Methods

In this double-blind, controlled clinical trial study, a total of 80 patients with GAD were randomly assigned into two groups. For the intervention group, at the same time as SSRI drug, two 500-mg ginger capsules were used daily while in the control group, two starch capsules were used daily as a placebo along with SSRI. Data collection tools were Hamilton's anxiety questionnaire and a gastrointestinal symptom severity scale. Data were collected before the intervention and after the 12-week intervention.

Results

There was no significant difference between the intervention and control groups in terms of average anxiety and severity of digestive symptoms before the intervention ( > 0.05), but there was a significant difference between the groups after the intervention ( < 0.05). Also, the average scores of anxiety and severity of gastrointestinal symptoms in the intervention group increased significantly from the beginning of the intervention to the follow-up (intragroup difference) ( < 0.05).

Conclusion

The results of the study showed that the use of ginger along with SSRIs reduced anxiety and released the severity of gastrointestinal symptoms in patients with GAD. In addition, in this study, it was found that ginger, along with SSRIs, can have beneficial effects on indigestion, diarrhea, and nausea in patients with GAD. However, these findings require more extensive research.

Clinical Trial Registration No.

IRCT20201108049306N1.

© 2025 Bentham Science Publishers
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2025-05-01
2024-11-21

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References

  1. RuscioA.M. HallionL.S. LimC.C.W. Aguilar-GaxiolaS. Al-HamzawiA. AlonsoJ. Cross-sectional Comparison of the Epidemiology of DSM-5 GAD Across the Globe.JAMA Psychiatry201774546547510.1001/jamapsychiatry.2017.0056 28297020
     [Google Scholar]
  2. TerlizziE.P. VillarroelM.A. Symptoms of Generalized Anxiety Disorder Among Adults: United States, 2019.NCHS Data Brief202037818
     [Google Scholar]
  3. FayazbakhshE. MansouriA. Effectiveness of acceptance and commitment therapy on intolerance of uncertainty, experiential avoidance, and symptoms of GAD in individuals with Type II diabetes.International Archives of Health Sciences2019613010.4103/iahs.iahs_52_18
     [Google Scholar]
  4. BandelowB. MichaelisS. WedekindD. Treatment of anxiety disorders.Dialogues Clin. Neurosci.201719293107 28867934
     [Google Scholar]
  5. BandelowB. WernerA.M. KoppI. RudolfS. WiltinkJ. BeutelM.E. The German Guidelines for the treatment of anxiety disorders: First revision.Eur. Arch. Psychiatry Clin. Neurosci.2022272457158210.1007/s00406‑021‑01324‑1 34609587
     [Google Scholar]
  6. Elvir-LazoO.L. WhiteP.F. Cruz EngH. YumulF. ChuaR. YumulR. Impact of chronic medications in the perioperative period: Mechanisms of action and adverse drug effects (Part I).Postgrad. Med.2021133893995210.1080/00325481.2021.1982297 34551662
     [Google Scholar]
  7. LiH. LiuY. LuoD. Ginger for health care: An overview of systematic reviews.Complement. Ther. Med.20194511412310.1016/j.ctim.2019.06.002 31331547
     [Google Scholar]
  8. BashirF. AfrinZ. Zanjabeel (Zingiber offcinale) Transformation of Culinary Spice to a multi-functional Medicine.J. Drug Deliv. Ther.201994-s72172510.22270/jddt.v9i4‑s.3299
     [Google Scholar]
  9. NievergeltA. HuonkerP. SchoopR. AltmannK.H. GertschJ. Identification of serotonin 5-HT1A receptor partial agonists in ginger.Bioorg. Med. Chem.20101893345335110.1016/j.bmc.2010.02.062 20363635
     [Google Scholar]
  10. ClarkD.B. DonovanJ. Reliability and validity of the Hamilton Anxiety Rating Scale in an adolescent sample.J. Am. Acad. Child Adolesc. Psychiatry199433335436010.1097/00004583‑199403000‑00009 8169180
     [Google Scholar]
  11. RevickiD.A. WoodM. WiklundI. CrawleyJ. Reliability and validity of the Gastrointestinal Symptom Rating Scale in patients with gastroesophageal reflux disease.Qual. Life Res.199771758310.1023/A:1008841022998 9481153
     [Google Scholar]
  12. MazaheriM. Comparison between psychometric characteristics of persian version of the gastrointestinal symptoms rating scale in functional gastrointestinal disorders and normal groups.Govaresh20121711824
     [Google Scholar]
  13. RahmaniM. ZanjaniZ. OmidiA. The Mediating Role of Cognitive Emotion Regulation and Mindfulness in the Relationship Between Worry and Generalized Anxiety.J. Arak Univ. Med. Sci.202225114215510.32598/jams.25.1.6730.1
     [Google Scholar]
  14. RobergeP. Normand-LauzièreF. RaymondI. LucM. Tanguay-BernardM.M. DuhouxA. GAD in primary care: Mental health services use and treatment adequacy.BMC Fam. Pract.20151614610.1186/s12875‑015‑0358‑y 26492867
     [Google Scholar]
  15. GrenierS. DesjardinsF. RaymondB. PayetteM.C. RiouxM. LandrevilleP. Six-month prevalence and correlates of GAD among primary care patients aged 70 years and above: Results from the ESA-services study.Int. J. Geriatr. Psychiatry201934231532310.1002/gps.5023 30418683
     [Google Scholar]
  16. LeonardK. AbramovitchA. Cognitive functions in young adults with GAD.Eur. Psychiatry2019561710.1016/j.eurpsy.2018.10.008 30458333
     [Google Scholar]
  17. O’BrienK. O’KeeffeN. CullenH. DurcanA. TimulakL. McElvaneyJ. Emotion-focused perspective on GAD: A qualitative analysis of clients’ in-session presentations.Psychother. Res.201929452454010.1080/10503307.2017.1373206 28893153
     [Google Scholar]
  18. SihombingA.T. PrabharaniD. LukmanK. SudjudR.W. The effectiveness of ginger extract addition in calorified drinks during perioperative period to nausea severity, vomitus, post-operative anxiety, and metabolic disorder: A randomized control trial.Ann. Med. Surg. (Lond.)20228410486510.1016/j.amsu.2022.104865 36536711
     [Google Scholar]
  19. JiangF. KobayashiT. IchihashiT. ItoK. NomuraS. The effect of citrus ginger aroma on heart rate and salivary cortisol level during sleep at home.IEEJ Trans. Electr. Electron. Eng.201914462362910.1002/tee.22845
     [Google Scholar]
  20. Machado-VieiraR. BaumannJ. Wheeler-CastilloC. The Timing of Antidepressant Effects: A Comparison of Diverse Pharmacological and Somatic Treatments.Pharmaceuticals (Basel)201031194110.3390/ph3010019 27713241
     [Google Scholar]
  21. RostamkhaniM. KhosraviS. RezaieK. ForozanA. RafieiF. The effect of ginger on the symptoms of irritable bowel syndrome: A randomized clinical trial.J. Med. Plants20181768112121
     [Google Scholar]
  22. GiacosaA. GuidoD. GrassiM. The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial.Evid. Based Complement. Alternat. Med.201520151910.1155/2015/915087 25954317
     [Google Scholar]
  23. Nikkhah BodaghM. MalekiI. HekmatdoostA. Ginger in gastrointestinal disorders: A systematic review of clinical trials.Food Sci. Nutr.2019719610810.1002/fsn3.807 30680163
     [Google Scholar]
  24. TavlanA. TuncerS. ErolA. ReisliR. AysolmazG. OtelciogluS. Prevention of postoperative nausea and vomiting after thyroidectomy: Combined antiemetic treatment with dexamethasone and ginger versus dexamethasone alone.Clin. Drug Investig.200626420921410.2165/00044011‑200626040‑00005 17163253
     [Google Scholar]
  25. BlumenthalM. Ginger as an antiemetic during pregnancy.Altern. Ther. Health Med.2003911921 12564347
     [Google Scholar]
  26. KiuchiF. ShibuyaM. SankawaU. Inhibitors of prostaglandin biosynthesis from ginger.Chem. Pharm. Bull. (Tokyo)198230275475710.1248/cpb.30.754 7094159
     [Google Scholar]
/content/journals/cprr/10.2174/0126660822258340231025171755
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Investigating the Effect of Ginger as an Adjunctive Treatment along with SSRIs to Reduce Anxiety in Patients with GAD: A Clinical Trial Study
Curr Psyc Res Rev 21, 177 (2025); https://doi.org/10.2174/0126660822258340231025171755
/content/journals/cprr/10.2174/0126660822258340231025171755
/content/journals/cprr/10.2174/0126660822258340231025171755
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  • Article Type:     Research Article
Keyword(s): adjunctive treatment; gastrointestinal symptoms; generalized anxiety disorder; Ginger; SSRI; Zingiber officinale

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