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2000
Volume 21, Issue 2
  • ISSN: 2666-0822
  • E-ISSN: 2666-0830

Abstract

In the primary phases of Alzheimer's disease (AD) and vascular dementia, memory impairments and cognitive abnormalities are common. Because of the rising prevalence of dementia among the elderly, it is critical to promote healthy habits that can delay the onset of cognitive decline. Cognitive training (CT) and cognitive rehabilitation (CR) are particular treatments aimed to resolve memory and further areas of cognitive working in order to overcome these challenges. These are some of the different kinds of non-pharmacological treatments like reality orientation and skills training programs that can be used to deal with the cognitive and non-cognitive repercussions. The purpose of this review is to assess the efficacy and influence of cognitive training and cognitive rehabilitation in patients who are in their early phases of Alzheimer's disease or vascular dementia. These interventions are geared toward improving the patients' memory, in addition to other aspects of their cognitive functioning.

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2025-05-01
2024-11-21
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References

  1. UddinM.S. RahmanM.A. KabirM.T. Multifarious roles of mTOR signaling in cognitive aging and cerebrovascular dysfunction of Alzheimer’s disease.IUBMB Life20207291843185510.1002/iub.2324 32472959
    [Google Scholar]
  2. MittalP. DhankharS. ChauhanS. A review on natural antioxidants for their role in the treatment of parkinson’s disease.Pharmaceuticals202316790810.3390/ph16070908 37513820
    [Google Scholar]
  3. KumarM. KumarA. SindhuR.K. KushwahA.S. Arbutin attenuates monosodium L-glutamate induced neurotoxicity and cognitive dysfunction in rats.Neurochem. Int.202115110521710.1016/j.neuint.2021.105217 34710534
    [Google Scholar]
  4. DhankarS. MujwarS. GargN. Artificial intelligence in the management of neurodegenerative disorders.CNS Neurol. Disord. Drug Targets202323110 37861051
    [Google Scholar]
  5. ReiflerB.V. LarsonE. Excess disability in dementia of the Alzheimer’s type.Alzheimer’s disease treatment and family stress: Directions for research. LightE. LebowitzD. US Department of Health & Human Services1989363382
    [Google Scholar]
  6. DhankharS. ChauhanS. MehtaD.K. Novel targets for potential therapeutic use in diabetes mellitus.Diabetol. Metab. Syndr.20231511710.1186/s13098‑023‑00983‑5 36782201
    [Google Scholar]
  7. SalomoneS. CaraciF. LeggioG.M. FedotovaJ. DragoF. New pharmacological strategies for treatment of Alzheimer’s disease: Focus on disease modifying drugs.Br. J. Clin. Pharmacol.201273450451710.1111/j.1365‑2125.2011.04134.x 22035455
    [Google Scholar]
  8. WeiS. MaiY. PengW. The effect of nonpharmacologic therapy on global cognitive functions in patients with Alzheimer’s disease: An updated meta-analysis of randomized controlled trials.Int. J. Neurosci.20201301284410.1080/00207454.2019.1638377 31251099
    [Google Scholar]
  9. ClareL. WoodsR.T. Moniz CookE.D. OrrellM. SpectorA. Cognitive rehabilitation and cognitive training for early-stage Alzheimer’s disease and vascular dementia.Cochrane Libr.200344CD00326010.1002/14651858 14583963
    [Google Scholar]
  10. SmallG.W. RabinsP.V. BarryP.P. Diagnosis and treatment of Alzheimer disease and related disorders: Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer’s Association, and the American Geriatrics Society.JAMA1997278161363137110.1001/jama.1997.03550160083043 9343469
    [Google Scholar]
  11. WoodsR.T. ClareL. Cognition-based therapies and mild cognitive impairment. Mild Cognitive Impairment.Psychology Press2013244263
    [Google Scholar]
  12. ChoiJ. TwamleyE.W. Cognitive rehabilitation therapies for Alzheimer’s disease: A review of methods to improve treatment engagement and self-efficacy.Neuropsychol. Rev.2013231486210.1007/s11065‑013‑9227‑4 23400790
    [Google Scholar]
  13. SoldanA. PettigrewC. CaiQ. Cognitive reserve and long-term change in cognition in aging and preclinical Alzheimer’s disease.Neurobiol. Aging20176016417210.1016/j.neurobiolaging.2017.09.002 28968586
    [Google Scholar]
  14. WoodsB. Cognitive stimulation to improve cognitive functioning in people with dementia.Cochrane Database Syst. Rev.2023152CD005562
    [Google Scholar]
  15. ShaffnerJ. Neuroplasticity and clinical practice: Building brain power for health.Front. Psychol.201671118
    [Google Scholar]
  16. SaharanR. KaurJ. DhankharS. Hydrogel-based drug delivery system in diabetes management.Pharm. Nanotechnol.202412428929910.2174/0122117385266276230928064235 37818559
    [Google Scholar]
  17. Sampedro-PiqueroP. BegegaA. Environmental enrichment as a positive behavioral intervention across the lifespan.Curr. Neuropharmacol.201715445947010.2174/1570159X14666160325115909 27012955
    [Google Scholar]
  18. ClareL. BayerA. BurnsA. Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT).Trials201314115210.1186/1745‑6215‑14‑152 23710796
    [Google Scholar]
  19. HeissW-D. KesslerJ. MielkeR. SzeliesB. HerholzK. Long-term effects of phosphatidylserine, pyritinol, and cognitive training in Alzheimer’s disease. A neuropsychological, EEG, and PET investigation.Dementia1994528898 8038871
    [Google Scholar]
  20. ClareL. LindenD.E.J. WoodsR.T. Goal-oriented cognitive rehabilitation for people with early-stage Alzheimer disease: A single-blind randomized controlled trial of clinical efficacy.Am. J. Geriatr. Psychiatry2010181092893910.1097/JGP.0b013e3181d5792a 20808145
    [Google Scholar]
  21. ButlerP.D. ZemonV. SchechterI. Early-stage visual processing and cortical amplification deficits in schizophrenia.Arch. Gen. Psychiatry200562549550410.1001/archpsyc.62.5.495 15867102
    [Google Scholar]
  22. ClareL. WoodsR.T. Cognitive training and cognitive rehabilitation for people with early-stage Alzheimer’s disease: A review.Neuropsychol. Rehabil.200414438540110.1080/09602010443000074
    [Google Scholar]
  23. WilsonB.A. Towards a comprehensive model of cognitive rehabilitation.Neuropsychol. Rehabil.20021229711010.1080/09602010244000020
    [Google Scholar]
  24. LoewensteinD.A. AcevedoA. CzajaS.J. DuaraR. Cognitive rehabilitation of mildly impaired Alzheimer disease patients on cholinesterase inhibitors.Am. J. Geriatr. Psychiatry200412439540210.1097/00019442‑200407000‑00007 15249277
    [Google Scholar]
  25. SitzerD.I. TwamleyE.W. JesteD.V. Cognitive training in Alzheimer’s disease: A meta‐analysis of the literature.Acta Psychiatr. Scand.20061142759010.1111/j.1600‑0447.2006.00789.x 16836595
    [Google Scholar]
  26. LalitK. Phyto-pharmacological review of Coccinia indica.World J. Pharm. Pharm. Sci.20143217341745
    [Google Scholar]
  27. BuschertV. BokdeA.L.W. HampelH. Cognitive intervention in Alzheimer disease.Nat. Rev. Neurol.20106950851710.1038/nrneurol.2010.113 20717104
    [Google Scholar]
  28. ValenzuelaM. SachdevP. Can cognitive exercise prevent the onset of dementia? Systematic review of randomized clinical trials with longitudinal follow-up.Am. J. Geriatr. Psychiatry200917317918710.1097/JGP.0b013e3181953b57 19225276
    [Google Scholar]
  29. CotelliM. CalabriaM. ZanettiO. Cognitive rehabilitation in Alzheimer’s disease.Aging Clin. Exp. Res.200618214114310.1007/BF03327429 16702783
    [Google Scholar]
  30. SpectorA. OrrellM. WoodsB. Cognitive Stimulation Therapy (CST): Effects on different areas of cognitive function for people with dementia.Int. J. Geriatr. Psychiatry201025121253125810.1002/gps.2464 20069533
    [Google Scholar]
  31. TárragaL. BoadaM. ModinosG. A randomised pilot study to assess the efficacy of an interactive, multimedia tool of cognitive stimulation in Alzheimer’s disease.J. Neurol. Neurosurg. Psychiatry200677101116112110.1136/jnnp.2005.086074 16820420
    [Google Scholar]
  32. RaoG. SivakumarP. SrivastavaS. SidanaR. Cognitive therapy and family intervention for patients with dementia and psychosis.Indian J. Psychiatry202062818310.4103/psychiatry.IndianJPsychiatry_769_19 32055061
    [Google Scholar]
  33. TalassiE. GuerreschiM. FerianiM. FediV. BianchettiA. TrabucchiM. Effectiveness of a cognitive rehabilitation program in mild dementia (MD) and mild cognitive impairment (MCI): A case control study.Arch. Gerontol. Geriatr.200744S139139910.1016/j.archger.2007.01.055 17317481
    [Google Scholar]
  34. CiprianiG. BianchettiA. TrabucchiM. Outcomes of a computer-based cognitive rehabilitation program on Alzheimer’s disease patients compared with those on patients affected by mild cognitive impairment.Arch. Gerontol. Geriatr.200643332733510.1016/j.archger.2005.12.003 16451811
    [Google Scholar]
  35. MooreS. SandmanC.A. McGradyK. Patrick KesslakJ. Memory training improves cognitive ability in patients with dementia.Neuropsychol. Rehabil.2001113-424526110.1080/09602010042000222
    [Google Scholar]
  36. BamfordC. LamontS. EcclesM. RobinsonL. MayC. BondJ. Disclosing a diagnosis of dementia: A systematic review.Int. J. Geriatr. Psychiatry200419215116910.1002/gps.1050 14758581
    [Google Scholar]
  37. IliffeS. Primary care and dementia: 1. diagnosis, screening and disclosure.Int. J. Geriatr. Psychiatry2009249895901
    [Google Scholar]
  38. SantacruzK.S. SwagertyD.Jr Early diagnosis of dementia.Am. Fam. Physician2001634703713, 717-718 11237085
    [Google Scholar]
  39. CotrellV. SchulzR. The perspective of the patient with Alzheimer’s disease: A neglected dimension of dementia research.Gerontologist199333220521110.1093/geront/33.2.205 8468013
    [Google Scholar]
  40. AaltenP. Van ValenE. ClareL. KennyG. VerheyF. Awareness in dementia: A review of clinical correlates.Aging Ment. Health20059541442210.1080/13607860500143075 16024400
    [Google Scholar]
  41. VogelA. StokholmJ. GadeA. AndersenB.B. HejlA.M. WaldemarG. Awareness of deficits in mild cognitive impairment and Alzheimer’s disease: Do MCI patients have impaired insight?Dement. Geriatr. Cogn. Disord.200417318118710.1159/000076354 14739542
    [Google Scholar]
  42. RosaE. LussignoliG. SabbatiniF. Needs of caregivers of the patients with dementia.Arch. Gerontol. Geriatr.2010511545810.1016/j.archger.2009.07.008 19853313
    [Google Scholar]
  43. BrodatyH. GreshamM. Effect of a training programme to reduce stress in carers of patients with dementia.BMJ198929967121375137910.1136/bmj.299.6712.1375 2513967
    [Google Scholar]
  44. WoodsB. PrattR. Awareness in dementia: Ethical and legal issues in relation to people with dementia.Aging Ment. Health20059542342910.1080/13607860500143125 16024401
    [Google Scholar]
  45. KappM.B. Legal issues in dementia.Int. J. Risk Saf. Med.2008201-29110310.3233/JRS‑2008‑0429
    [Google Scholar]
  46. GaneshS. Care arrangements for persons with dementia: A review on formal care and its relevance to Indian context.J. Geriatr. Care Res.2016322734
    [Google Scholar]
  47. ChangC.C. RobertsB.L. Feeding difficulty in older adults with dementia.J. Clin. Nurs.200817172266227410.1111/j.1365‑2702.2007.02275.x 18705703
    [Google Scholar]
  48. Vernooij-DassenM. VasseE. ZuidemaS. Cohen-MansfieldJ. MoyleW. Psychosocial interventions for dementia patients in long-term care.Int. Psychogeriatr.20102271121112810.1017/S1041610210001365 20813074
    [Google Scholar]
  49. ShajiK.S. SivakumarP.T. RaoG.P. PaulN. Clinical practice guidelines for management of dementia.Indian J. Psychiatry201860731210.4103/0019‑5545.224472 29535467
    [Google Scholar]
  50. Kasl-GodleyJ. GatzM. Psychosocial interventions for individuals with dementia.Clin. Psychol. Rev.200020675578210.1016/S0272‑7358(99)00062‑8 10983267
    [Google Scholar]
  51. SwanK. HopperM. WenkeR. JacksonC. TillT. ConwayE. Speech-language pathologist interventions for communication in moderate–severe dementia: A systematic review.Am. J. Speech Lang. Pathol.201827283685210.1044/2017_AJSLP‑17‑0043 29554196
    [Google Scholar]
  52. BoccardiM. FrisoniG.B. Cognitive rehabilitation for severe dementia: Critical observations for better use of existing knowledge.Mech. Ageing Dev.2006127216617210.1016/j.mad.2005.09.027 16280151
    [Google Scholar]
  53. GaitánA. GaroleraM. CerullaN. ChicoG. Rodriguez-QuerolM. Canela-SolerJ. Efficacy of an adjunctive computer-based cognitive training program in amnestic mild cognitive impairment and Alzheimer’s disease: A single-blind, randomized clinical trial.Int. J. Geriatr. Psychiatry2013281919910.1002/gps.3794 22473855
    [Google Scholar]
  54. González-PalauF. FrancoM. BamidisP. The effects of a computer-based cognitive and physical training program in a healthy and mildly cognitive impaired aging sample.Aging Ment. Health201418783884610.1080/13607863.2014.899972 24697325
    [Google Scholar]
  55. VanovaM. IrazokiE. García-CasalJ.A. The effectiveness of ICT-based neurocognitive and psychosocial rehabilitation programmes in people with mild dementia and mild cognitive impairment using GRADIOR and ehcoBUTLER: Study protocol for a randomised controlled trial.Trials201819110010.1186/s13063‑017‑2371‑z 29433545
    [Google Scholar]
  56. Mendoza LaizN. Del Valle DíazS. Rioja ColladoN. Gomez-PilarJ. HorneroR. Potential benefits of a cognitive training program in mild cognitive impairment (MCI).Restor. Neurol. Neurosci.201836220721310.3233/RNN‑170754 29526855
    [Google Scholar]
  57. HwangJ.H. ChaH.G. ChoY.S. KimT.S. ChoH.S. The effects of computer-assisted cognitive rehabilitation on Alzheimer’s dementia patients memories.J. Phys. Ther. Sci.20152792921292310.1589/jpts.27.2921 26504325
    [Google Scholar]
  58. DiamondK. MowszowskiL. CockayneN. Randomized controlled trial of a healthy brain ageing cognitive training program: Effects on memory, mood, and sleep.J. Alzheimers Dis.20154441181119110.3233/JAD‑142061 25408218
    [Google Scholar]
  59. GiuliC. PapaR. LattanzioF. PostacchiniD. The effects of cognitive training for elderly: Results from my mind project.Rejuvenation Res.201619648549410.1089/rej.2015.1791 26952713
    [Google Scholar]
  60. KurzA. Thöne-OttoA. CramerB. CORDIAL: cognitive rehabilitation and cognitive-behavioral treatment for early dementia in Alzheimer disease: A multicenter, randomized, controlled trial.Alzheimer Dis. Assoc. Disord.201226324625310.1097/WAD.0b013e318231e46e 21986341
    [Google Scholar]
  61. OrrellM. AguirreE. SpectorA. Maintenance cognitive stimulation therapy for dementia: Single-blind, multicentre, pragmatic randomised controlled trial.Br. J. Psychiatry2014204645446110.1192/bjp.bp.113.137414 24676963
    [Google Scholar]
  62. OrrellM. YatesL. LeungP. The impact of individual Cognitive Stimulation Therapy (iCST) on cognition, quality of life, caregiver health, and family relationships in dementia: A randomised controlled trial.PLoS Med.2017143e100226910.1371/journal.pmed.1002269 28350796
    [Google Scholar]
  63. VenturelliM. SollimaA. CèE. Effectiveness of exercise-and cognitive-based treatments on salivary cortisol levels and sundowning syndrome symptoms in patients with Alzheimer’s disease.J. Alzheimers Dis.20165341631164010.3233/JAD‑160392 27540967
    [Google Scholar]
  64. AmievaH. RobertP.H. GrandoulierA.S. Group and individual cognitive therapies in Alzheimer’s disease: The ETNA3 randomized trial.Int. Psychogeriatr.201628570771710.1017/S1041610215001830 26572551
    [Google Scholar]
  65. BuschertV.C. GieglingI. TeipelS.J. Long-term observation of a multicomponent cognitive intervention in mild cognitive impairment.J. Clin. Psychiatry20127312e1492e149810.4088/JCP.11m07270 23290333
    [Google Scholar]
  66. CoenR.F. FlynnB. RigneyE. Efficacy of a cognitive stimulation therapy programme for people with dementia.Ir. J. Psychol. Med.201128314514710.1017/S0790966700012131 30200025
    [Google Scholar]
  67. Fernández-CalvoB. ContadorI. RamosF. OlazaránJ. MograbiD.C. MorrisR.G. Effect of unawareness on rehabilitation outcome in a randomised controlled trial of multicomponent intervention for patients with mild Alzheimer’s disease.Neuropsychol. Rehabil.201525344847710.1080/09602011.2014.948461 25121567
    [Google Scholar]
  68. HuntleyJ.D. HampshireA. BorD. OwenA. HowardR.J. Adaptive working memory strategy training in early Alzheimer’s disease: Randomised controlled trial.Br. J. Psychiatry20172101616610.1192/bjp.bp.116.182048 27758836
    [Google Scholar]
  69. LawL.L.F. BarnettF. YauM.K. GrayM.A. Effects of functional tasks exercise on older adults with cognitive impairment at risk of Alzheimer’s disease: A randomised controlled trial.Age Ageing201443681382010.1093/ageing/afu055 24850540
    [Google Scholar]
  70. CavalloM. HunterE.M. van der HieleK. AngillettaC. Computerized structured cognitive training in patients affected by early-stage Alzheimer’s disease is feasible and effective: A randomized controlled study.Arch. Clin. Neuropsychol.201631886887610.1093/arclin/acw072 27600448
    [Google Scholar]
  71. BarbanF. AnnicchiaricoR. PantelopoulosS. Protecting cognition from aging and Alzheimer’s disease: A computerized cognitive training combined with reminiscence therapy.Int. J. Geriatr. Psychiatry201631434034810.1002/gps.4328 26205305
    [Google Scholar]
  72. DanassiE. SOCIABLE: A surface computing platform empowering effective cognitive training for healthy and cognitively impaired elderly.Adv. Exp. Med. Biol.201582112913010.1007/978‑3‑319‑08939‑3_18
    [Google Scholar]
  73. ZaccarelliC. Computer-based cognitive intervention for dementia Sociable: Motivating platform for elderly networking, mental reinforcement and social interaction. 2013 7th International Conference on Pervasive Computing Technologies for Healthcare and Workshops. 05-08 May 2013 Venice, Italy.201310.4108/icst.pervasivehealth.2013.252155
    [Google Scholar]
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