Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) - Volume 15, Issue 2, 2017

Background: Identification of clinical and molecular biomarkers to predict dynamic response or monitor in real-time the efficacy of antiangiogenic therapy represents a major point in the treatment of patients with advanced colorectal cancer. Several studies have been conduced to identify some predictive biomarkers to select patients who will benefit from bevacizumab, the most widely used antiangiogenic monoclonal antib Read More

Background: Sclerostin (SOST) is a secretary product of osteocytes and it is a glycoprotein expressed by SOST gene. It is well studied and established that sclerostin inhibits the bone formation by blocking Wnt signaling pathway. SOST gene acts as a potential therapeutic target for treating autosomal disorders, like van Buchem disease and sclerosteosis. Bioinformatics analysis of SOST gene shall provide exhaustive i Read More

Background: Evidence now suggests that precision medicine, which is sometimes used interchangeably with personalized medicine, is becoming a cornerstone of medical practices by providing the right patient with the right medication at the right dose at the right time. In the light of the recent advances in biomedical computing and big data science, more and more genetic variants associated with human diseases and treatmen Read More

Background: Thymidylate synthase (TS) encoded by the TYMS gene is a target for cancer chemotherapeutic drugs such as 5-fluorouracil (5-FU). The overexpression of TS in several types of cancer confers poor response to 5-FU. The interpatient variation in TS levels can be due in part to functional genetic polymorphisms in TYMS gene: one of them is a variable number of 28-bp tandem repeats in its 5'-untranslated region Read More

Background: Single Nucleotide Polymorphisms (SNPs) in metformin transporter genes play an important role as the cause of inter-individual variability in metformin response. The SLC22A1 as an Organic Cation Transporter (OCT)1 coding gene is responsible for the metformin influx to hepatocytes, while the efflux to bile and excretion through the kidney are mainly facilitated by Multidrug and Toxin Extrusion (MATE)1 tra Read More

Background: A variety of genetic pathways have been described as being essential in drug abuse and myocardial ischemia (MI), including dopamine-2 receptor gene (DRD2) and serotonin transporter gene (SERT). However, there is insufficient information on how those genetic pathways could contribute to their comorbidity. Objectives: The study aimed to examine the potential association between drug abuse/m Read More

Background: Dectin-1 is a pattern recognition receptor that recognizes pathogenic fungi via carbohydrate moiety present on the cell wall. Single nucleotide polymorphisms in dectin-1 gene in an individual have been implicated in susceptibility to invasive infections in immunocompromised or immunocompetant host. Objective: We sought to analyze the deleterious nsSNP in dectin-1 gene for their susceptibility against fungal pa Read More