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Volume 21, Issue 3
  • ISSN: 1875-6921
  • E-ISSN: 1875-6913

Abstract

Introduction

Chemoresistance is one of the leading causes of chemotherapy failure among cancer patients. Out of several hypotheses proposed for chemoresistance, bacteria-mediated chemoresistance to cancer drugs has not been well established. Thus, the aim of this review is to map the pathways by which bacteria exhibit chemoresistance in specific cancers.

Material and Methods

Relevant articles on bacteria-mediated chemoresistance in cancer were retrieved by conducting a systematic search across PubMed, Scopus and Web of Science databases. The search was limited to English original articles published until 15th December 2023.

Results

A total of nine articles were included to map the pathways involved in chemoresistance. Numerous pathways have been connected to various forms of cancer, such as autophagy pathway in colorectal and esophageal cancers by causing oxaliplatin and 5-FU resistance; DNA damage response pathway also by promoting CDDP resistance in esophageal cancer; led to oral and esophageal cancer resistance to paclitaxel JAK/STAT pathway. NF-κB pathway involved in gastric cancer in the presence of towards cisplatin, and also 5-FU resistance the apoptotic pathway. Cellular metabolism modulation by was also implicated in cervical cancer chemoresistance.

Conclusion

We conclude that bacteria can mediate chemoresistance not merely to antibiotics but also to anticancer drugs. Thus, a detailed understanding of the pathways associated with chemoresistance mediated bacteria might help in targeting these pathways or antibiotics to prevent bacterial growth could help overcome resistance.

© 2024 Bentham Science Publishers
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2024-10-11
2025-01-30

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/content/journals/cppm/10.2174/0118756921339129240926055552
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Understanding Bacterial Roles in Cancer Chemo-resistance: A Signaling Pathway Mapping Study
Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) 21, 155 (2024); https://doi.org/10.2174/0118756921339129240926055552
/content/journals/cppm/10.2174/0118756921339129240926055552
/content/journals/cppm/10.2174/0118756921339129240926055552
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  • Article Type:     Review Article
Keyword(s): Antineoplastic agents; bacteria; cancer; chemoresistance; chemotherapy; signaling pathways
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