- Home
- A-Z Publications
- Current Pharmaceutical Design
- Previous Issues
- Volume 8, Issue 9, 2002
Current Pharmaceutical Design - Volume 8, Issue 9, 2002
Volume 8, Issue 9, 2002
-
-
Strategies for New Antimicrobial Proteins and Peptides: Lysozyme and Aprotinin as Model Molecules
Authors: H.R. Ibrahim, T. Aoki and A. PellegriniThe increasing development of bacterial resistance to traditional antibiotics has reached alarming levels, thus necessitating the strong need to develop new antimicrobial agents. These new antimicrobials should possess both novel modes of action as well as different cellular targets compared with the existing antibiotics. Lysozyme, muramidase, and aprotinin, a protease inhibitor, both exhibit antimicrobial activities a Read More
-
-
-
Tailoring an Antibacterial Peptide of Human Lysosomal Cathepsin G to Enhance its Broad-Spectrum Action Against Antibiotic-Resistant Bacterial Pathogens
Authors: W.M. Shafer, S. Katzif, S. Bowers, M. Fallon, M. Hubalek, M.S. Reed, P. Veprek and J. PohlNeutrophils contain several cationic antimicrobial proteins or peptides (CAPs) that exert antibiotic-like action against bacteria. These host-derived antibiotics kill susceptible bacteria by oxygen-independent mechanisms. Considerable interest in their activity has been generated in recent years due not only to their likely important role in innate host defense against infection, but also their possible use as therapeutic agents in tre Read More
-
-
-
Cationic Peptides: Distribution and Mechanisms of Resistance
Authors: D.A. Devine and R.E.W. HancockCationic antimicrobial peptides are observed throughout nature. In mammals they are observed both at epithelial surfaces and within the granules of phagocytic cells. They are an important component of innate defences, since in addition to their ability to kill microorganisms, they are able to modulate inflammatory responses. With respect to their ability to kill bacteria, it is very difficult to isolate resistant mutants. However th Read More
-
-
-
From Innate Immunity to de-Novo Designed Antimicrobial Peptides
By Y. ShaiAntimicrobial peptides are a large group of gene-encoded, net positively charged polypeptides, produced by living organisms of all types including human and plants. They are mobilized shortly after infection as part of the innate immunity of these species and act rapidly to neutralize a broad range of microbes. Nowadays, thousands of native and de-novo designed antimicrobial peptides are available. They vary considerably in Read More
-
-
-
Host-defense Antimicrobial Peptides: Importance of Structure for Activity
Authors: N. Sitaram and R. NagarajAntimicrobial peptides are important components of innate immunity in species across the evolutionary scale. Unlike therapeutically used antibiotics, this class of peptides exert their activity by permeabilizing bacterial membranes. Despite the seemingly common mechanism of action, there is considerable variation in their primary structures, length and number of positive charges. Host-defense antimicrobial peptides h Read More
-
-
-
Molecular Diversity in Gene-Encoded, Cationic Antimicrobial Polypeptides
More LessGene-encoded, ribosomally synthesised antimicrobial peptides (AMPs) are an ancient and pervasive component of the innate defence mechanisms used by multicellular organisms to control the natural flora and combat pathogens. Bacteria also produce such AMPs to maintain ecological niches free of rival strains. Several hundred different peptides have been characterised to date, and they show a marked degree of variability i Read More
-
-
-
Pro-rich Antimicrobial Peptides from Animals: Structure, Biological Functions and Mechanism of Action
Authors: R. Gennaro, M. Zanetti, M. Benincasa, E. Podda and M. MianiPro-rich antimicrobial peptides are a group of linear peptides of innate immunity isolated from mammals and invertebrates, and characterised by a high content of proline residues (up to 50%). Members of this group are predominantly active against Gram-negative bacterial species which they kill by a non-lytic mechanism, at variance with the majority of the known antimicrobial peptides. Evidence is accumulating that the Pro-ri Read More
-
-
-
Cathelicidin Peptides as Candidates for a Novel Class of Antimicrobials
Authors: M. Zanetti, R. Gennaro, B. Skerlavaj, L. Tomasinsig and R. CircoCathelicidin peptides are a numerous group of mammalian cationic antimicrobial peptides. Despite a common evolutionary origin of their genes, peptides display a remarkable variety of sizes, sequences and structures. Their spectra of antimicrobial activity are varied and cover a range of organisms that includes bacteria, fungi and enveloped viruses. In addition, they bind to and neutralize the effects of endotoxin. These fe Read More
-
-
-
Development of Short Antimicrobial Peptides Derived from Host Defense Peptides or by Combinatorial Libraries
By K-h. LeeRecent increase of antibiotic-resistant pathogens demands exploration of novel antimicrobial molecules with unexploited mechanisms. Several hundred host defense peptides have been isolated from natural sources and their functions characterized. As host defense peptides have several advantages over classic antibiotics for resistant pathogens, there are many efforts to develop host defense peptides as therapeutic age Read More
-
-
-
Multiple Activities in Lantibiotics - Models for the Design of Novel Antibiotics?
More LessLantibiotics are antibiotic peptides distinguished by the presence of the rare thioether amino acids lanthionine and / or methyllanthionine. They are produced by Grampositive bacteria as gene-encoded precursor peptides and undergo post-translational modification to generate the mature peptide. The structural gene for the prepeptide and the genes involved in biosynthesis, processing, export as well as regulation and prod Read More
-
Volumes & issues
-
Volume 31 (2025)
-
Volume 30 (2024)
-
Volume 29 (2023)
-
Volume 28 (2022)
-
Volume 27 (2021)
-
Volume 26 (2020)
-
Volume 25 (2019)
-
Volume 24 (2018)
-
Volume 23 (2017)
-
Volume 22 (2016)
-
Volume 21 (2015)
-
Volume 20 (2014)
-
Volume 19 (2013)
-
Volume 18 (2012)
-
Volume 17 (2011)
-
Volume 16 (2010)
-
Volume 15 (2009)
-
Volume 14 (2008)
-
Volume 13 (2007)
-
Volume 12 (2006)
-
Volume 11 (2005)
-
Volume 10 (2004)
-
Volume 9 (2003)
-
Volume 8 (2002)
-
Volume 7 (2001)
-
Volume 6 (2000)
Most Read This Month
Article
content/journals/cpd
Journal
10
5
false
en
