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- Volume 6, Issue 16, 2000
Current Pharmaceutical Design - Volume 6, Issue 16, 2000
Volume 6, Issue 16, 2000
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Positron Emission Tomography in Drug Development and Drug Evaluation.
Authors: A.M.J. Paans and W. VaalburgPositron Emission Tomography (PET) is an imaging modality which can determine biochemical and physiological processes in vivo in a quantitative way by using radiopharmaceuticals labeled with positron emitting radionuclides as [sup11 ]C, [sup13 ]N, [sup15 ]O and [sup18 ]F and by measuring the annihilation radiation using a coincidence technique. This includes also measurement of the pharmacokinetics of labeled drugs and t Read More
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Measuring Receptor Occupancy with PET.
By A. WaardeMany physiological and biochemical measurements can be performed noninvasively in humans with modern imaging techniques like magnetic resonance imaging (MRI), positron emission tomography (PET) or single-photon emission computed tomography (SPECT). This review focuses on the monitoring of drug-receptor interactions in patients and healthy volunteers with PET. Such studies depend on the availability of a suit Read More
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PET Studies of Brain Monoamine Transporters.
Authors: A. Laakso and J. HietalaMonoamine transporters are proteins mainly located on nerve terminals of dopaminergic, noradrenergic and serotonergic neurons. They are members of a larger sodium dependent transporter family and represent a major mechanism terminating the action of released neurotransmitter in the synaptic cleft. In addition to being important target molecules for many antidepressive drugs and substances of abuse, transporte Read More
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Regional Pharmacokinetics of Orally Administered PET Tracers.
Authors: A.J. Fischman, A.A. Bonab and R.H. RubinPositron emission tomography (PET) is currently the most useful imaging technique for noninvasive measurement of drug pharmacokinetics regionally in a variety of tissues. Over the past decade, PET measurements have provided many critical insights about the tissue distribution of several classes of drugs; neuroleptics, antimicrobials, antineoplastics, etc. PET measurements can be performed after any route of drug Read More
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Regional Distribution and Kinetics of Inhaled Pharmaceuticals.
Authors: M.S. Berridge, Z. Lee and D.L. HealdDrug biodistribution is often secondary to drug action. However, drugs that have a topical action and are deposited into the airway by inhalation are dependent on effective deposition at the intended site of action. Measurement of the distribution of such drugs in the airway is a useful tool. Distribution data can help to interpret clinical results, to evaluate products relative to each other, to optimize a new drug formulation, an Read More
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Monitoring Interactions at ATP-Dependent Drug Efflux Pumps.
More LessChemotherapeutic treatment of cancer patients is often unsuccessful, due to the involvement of various mechanisms, leading to multidrug resistance (MDR). In this review, I describe the mechanisms involved in MDR. Furthermore, results obtained by imaging of P-glycoprotein (P-gp) and the multidrug resistance associated protein (MRP) are reviewed.Single photon emission computed tomography (SPECT) and positron em Read More
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Evaluation of Drug Targeting Strategies and Liposomal Trafficking.
Authors: N. Oku, Y. Tokudome, T. Asai and H. TsukadaLiposomes, that are biodegradable and essentially non-toxic, can encapsulate both hydrophilic and hydrophobic materials, and are utilized as drug carriers for drug delivery systems (DDS). Recent progress in gene technology provides a novel modality of therapy for various diseases with a variety of newly-developed cationic liposomes. Delivery of agents to the reticuloendothelial system (RES) is easily achieved since most c Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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