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- Volume 16, Issue 13, 2010
Current Pharmaceutical Design - Volume 16, Issue 13, 2010
Volume 16, Issue 13, 2010
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Editorial [Hot topic:The Two Faces of High-Density Lipoprotein (Executive Editor: Sophie Van Linthout)
More LessEpidemiological studies have demonstrated for nearly 50 years that high-density lipoprotein (HDL) cholesterol levels are inversely correlated with the incidence of ischemic cardiovascular diseases. This inverse relationship is attributed to the role of HDL in reverse cholesterol transport, but may also be related to its anti-oxidative, anti-inflammatory, anti-apoptotic, or endothelial protective properties, so called pleiotropic effects. Read More
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High-Density Lipoprotein: Key Molecule in Cholesterol Efflux and the Prevention of Atherosclerosis
Authors: Illiana Meurs, Miranda Van Eck and Theo J.C. Van BerkelAccumulation of cholesterol by macrophages, leading to their transformation into foam cells is a key event in the initiation of atherosclerosis. As maintenance of cholesterol homeostasis in macrophages is essential to prevent foam cell formation, mechanisms by which macrophages export cellular cholesterol have been intensively investigated in recent years. Several epidemiological studies have shown that plasma levels of Read More
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Relevance of Sphingolipids in the Pleiotropic Protective Effects of High-Density Lipoproteins
Authors: Markus Tolle, Mirjam Schuchardt and Markus van der GietAtherosclerosis is the major cause of cardiovascular morbidity and mortality. A multitude of pro-atherogenic mediators are known liable for the initiation and progression of atherogenic vascular lesions. Only few endogenous molecules are known so far with cardiovascular protective properties, whereas high-density lipoprotein (HDL) is one of the most important. Beside cholesterol efflux, many pleiotropic cell-mediate Read More
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High-Density Lipoprotein-Mediated Anti-Atherosclerotic and Endothelial-Protective Effects: A Potential Novel Therapeutic Target in Cardiovascular Disease
Authors: Christian Besler, Kathrin Heinrich, Meliana Riwanto, Thomas F. Luscher and Ulf LandmesserReduced levels of high-density lipoprotein cholesterol (HDL) are associated with a substantially increased risk of coronary disease and cardiovascular events. Furthermore, numerous studies have suggested that HDL may exert several potentially important antiatherosclerotic and endothelial-protective effects. In particular, the promotion of reverse cholesterol transport, i.e. cholesterol efflux from lipid-loaded macr Read More
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High-Density Lipoprotein Quantity or Quality for Cardiovascular Prevention?
Authors: Laura Calabresi, Monica Gomaraschi and Guido FranceschiniPlasma concentrations of HDL cholesterol (HDL-C) are strongly and inversely associated with cardiovascular risk, leading to the concept that therapies to enhance plasma HDL-C levels would be anti-atherogenic and protective against cardiovascular events. However, HDL are highly heterogeneous, with subclasses that can be separated and identified according to density, size, charge, and protein composition. There i Read More
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High-Density Lipoprotein at the Interface of Type 2 Diabetes Mellitus And Cardiovascular Disorders
Authors: Sophie Van Linthout, Frank Spillmann, Heinz-Peter Schultheiss and Carsten TschopeType 2 diabetes mellitus is associated with low high-density lipoprotein (HDL) cholesterol levels, which is an independent cardiovascular risk factor. Low HDL cholesterol concentrations reflect a dysregulation in HDL metabolism, which is determined by the concerted action of different proteins, including cholesterol ester transfer protein, lecithin: cholesterol acyltransferase, endothelial and lipoprotein lipase, phospholipid transfer Read More
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High-Density Lipoprotein-Raising Strategies: Update 2010
Authors: Frank Spillmann, Heinz-Peter Schultheiss, Carsten Tschope and Sophie Van LinthoutPopulation studies have consistently shown that high-density lipoprotein (HDL) cholesterol levels are a strong, independent inverse predictor of cardiovascular disease. Every 1 mg/dl increase in HDL cholesterol is associated with a 2% to 3% decrease in coronary artery disease risk, independent of low-density lipoprotein (LDL) cholesterol and triglyceride levels. The primary mechanism for this protective effect is belie Read More
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Gene Therapy to Improve High-Density Lipoprotein Metabolism and Function
Authors: Eline Van Craeyveld, Stephanie Gordts, Frank Jacobs and Bart De GeestPlasma levels of high-density lipoprotein (HDL) cholesterol and its major apolipoprotein (apo), apo A-I, are inversely correlated with the incidence of ischemic cardiovascular diseases. Till now, evaluation of the hypothesis that elevation of HDL cholesterol reduces atherosclerotic burden and/or decreases ischemic cardiovascular events in humans has been hampered by the lack of drugs that selectively increase HDL cholesterol. Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
- Issue 38
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- Issue 1
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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