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- ISSN: 1381-6128
- E-ISSN: 1873-4286
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Animal Models of Systemic Sclerosis
- Source: Current Pharmaceutical Design, Volume 21, Issue 18, Jun 2015, p. 2365 - 2379
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- 01 Jun 2015
Abstract
Systemic sclerosis is a systemic connective tissue disorder characterized by the fibrosis of the skin and certain visceral organs, vasculopathy, and immunological abnormalities. Several genetic and inducible animal models of SSc have been developed and are available for research studies. The purpose of this review is to summarize the various animal models of systemic sclerosis and describe the various contributions of these models in terms of understanding the pathophysiology of the condition and searching for new therapeutic strategies for this incurable disease.
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