Full text loading...
- ISSN: 1381-6128
- E-ISSN: 1873-4286
-
The Use of the Inhibitory Receptors for Modulating the Immune Responses
- Source: Current Pharmaceutical Design, Volume 14, Issue 26, Sep 2008, p. 2643 - 2650
-
- 01 Sep 2008
Abstract
Inhibitory receptors of the CD28 family, CTLA-4 and PD-1 deliver negative signals that regulate the balance between T cell activation, tolerance, and immunopathology. Manipulation of these pathways has been utilized by pathogens and tumors to establish chronic infections or to promote tumor survival. In this review, we examine the role of CTLA-4 and PD-1 in regulating immune response and discuss their therapeutic potential during aging.
© Bentham Science Publishers