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Volume 31, Issue 14
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Diabetic neuropathy (DN) is a widespread and severely debilitating consequence of diabetes mellitus that impairs function, causes discomfort, and damages peripheral nerves. Numerous molecular pathways are involved in the pathogenesis of DN, including cyclooxygenase, polyol, protein kinase C, and inflammatory pathways. These molecular pathways may be responsible for the mechanism behind the onset and development of DN. The metabolic profile can be evaluated by examining the molecular mechanisms that connect diabetes to certain biochemical indicators. Historically, the use of plants and herbs as medicine has been highly valued in many populations. These traditional sources, either alone or in combination with contemporary drugs, are being studied by modern medicine for their potential applications in managing and treating diabetic neuropathy. The efficacy and potential negative effects of an herb are largely dependent on its purity and provenance. Rich supplies of bioactive chemicals with particular pharmacological qualities that don't have negative side effects can be found in many plants. Some phytoconstituents with antidiabetic properties are found in medicinal plants, including terpenoids, saponins, flavonoids or carotenoids, alkaloids, and glycosides. We conclude with the statement that developing novel therapeutic procedures for the therapy of DN would be aided by the effective manipulation of common molecular pathways.

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/content/journals/cpd/10.2174/0113816128335400241101115928
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Exploring the Therapeutic Potential of Natural Plants in Modulating Molecular and Cellular Pathways Involved in Diabetic Neuropathy: Mechanism and Biochemical Evaluation
Curr. Pharm. Des. 31, 1087 (2025); https://doi.org/10.2174/0113816128335400241101115928
/content/journals/cpd/10.2174/0113816128335400241101115928
/content/journals/cpd/10.2174/0113816128335400241101115928
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  • Article Type:     Review Article
Keyword(s): biochemical parameter; diabetes; diabetic neuropathy; molecular pathways; Natural, plants/phytoconstituents

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