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Volume 31, Issue 14
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Background

The Prickle2 (Pk2) gene shows promising potential in uncovering the underlying causes of epilepsy, a neurological disorder that is currently not well understood. This paper utilizes the online tool PubMed to gather and condense information on the involvement of PCP channels and the associated roles of PCP pathway molecules in the onset of epilepsy. These findings are significant for advancing epilepsy treatment. Additionally, the paper discusses future directions for clinical trials and outlines potential therapeutic targets.

Methods

This review systematically analyzes the biological functions and mechanisms of the Prickle2 gene in epilepsy. Studies were retrieved from PubMed using keywords such as “Prickle2”, “epilepsy”, and “PCP pathway”, focusing on research published between 2000 and 2023 in English. Inclusion criteria included original studies and reviews on Prickle2's role in epilepsy. Studies unrelated to these topics or lacking sufficient data were excluded. Key data on Prickle2's functions and its link to epilepsy were extracted, and findings were summarized after a quality assessment of the literature.

Results

Although there are currently conflicting results regarding the possibility that Prickle2 may cause epilepsy in different organisms, we believe that as more cases involving Prickle2 mutations are reported and more related animal experiments are conducted, the findings will become clearer.

Conclusion

Due to the biological functions and mechanisms associated with the Prickle2 protein, it may serve as a useful biomarker or potential therapeutic target for epilepsy treatment.

© 2025 Bentham Science Publishers
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2025-01-01
2025-04-19

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Decoding Epilepsy: Prickle2 and Multifaceted Molecular Pathway Connections
Curr. Pharm. Des. 31, 1130 (2025); https://doi.org/10.2174/0113816128333500241031100623
/content/journals/cpd/10.2174/0113816128333500241031100623
/content/journals/cpd/10.2174/0113816128333500241031100623
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  • Article Type:     Review Article
Keyword(s): axon initial segment; epilepsy; molecular pathway; PCP pathway; Prickle2; protein interactions

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