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Volume 31, Issue 6
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Introduction

The current study aims to investigate the blood Hcy levels in patients with CAD and hypertension in Serbia, a country with a high incidence and mortality of both diseases.

Methods

The level of Hcy in the Serbian population was assessed in 123 patients with chronic coronary artery disease (CAD) and hypertension. There were 53 patients with chronic CAD and 70 patients with hypertension (HTA), but without CAD.

Results

The Hcy levels were high in both groups of patients (the mean Hcy level of 16.0 ± 7.0 µmol/L) without a statistical difference between the patients in the CAD (14.9 ± 7.3 µmol/L) and hypertension (16.7 ± 6.7 µmol/L) groups. Hypercholesterolemia was found in 81% of the patients with CAD and 92.0% of the patients with HTA, as a common concern across both clinical conditions. It was also found that not a single conventional risk factor (diabetes, hypertension, the smoking status, the family history of CAD, and hyperlipidemia) may individually influence Hcy levels. By contrast, the low levels of vitamin B12 may be related to the high levels of Hcy.

Conclusion

Given the fact that it is known that various factors interact and influence Hcy levels and associated cardiovascular risks, specific dietary habits, lifestyle and the other Serbia-specific possible factors were done.

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References

  1. LonnE. YusufS. ArnoldM.J. SheridanP. PogueJ. MicksM. McQueenM.J. ProbstfieldJ. FodorG. HeldC. GenestJ.Jr Homocysteine lowering with folic acid and B vitamins in vascular disease.N. Engl. J. Med.2006354151567157710.1056/NEJMoa06090016531613
     [Google Scholar]
  2. ChrysantS.G. ChrysantG.S. The current status of homocysteine as a risk factor for cardiovascular disease: A mini review.Expert Rev. Cardiovasc. Ther.201816855956510.1080/14779072.2018.149797429979619
     [Google Scholar]
  3. DjuricD. JakovljevicV. Rasic-MarkovicA. DjuricA. StanojlovicO. Homocysteine, folic acid and coronary artery disease: Possible impact on prognosis and therapy.Indian J. Chest Dis. Allied Sci.2008501394818610689
     [Google Scholar]
  4. FoscolouA. RallidisL.S. TsirebolosG. CritselisE. KatsimardosA. DrosatosA. ChrysohoouC. TousoulisD. PitsavosC. PanagiotakosD.B. The association between homocysteine levels, Mediterranean diet and cardiovascular disease: A case-control study.Int. J. Food Sci. Nutr.201970560361110.1080/09637486.2018.154768830501542
     [Google Scholar]
  5. WaldD.S. LawM. MorrisJ.K. Homocysteine and cardiovascular disease: Evidence on causality from a meta-analysis.BMJ200232573741202120610.1136/bmj.325.7374.120212446535
     [Google Scholar]
  6. BeletićA. MirkovićD. AntonijevićN. ĐorđevićV. ŠangoV. JakovljevićB. PeruničićJ. IlićM. VasiljevićZ. Majkić-SinghN. Incidence of hypehomocysteinemia and MTHFR C677T polymorphism among young patients with acute myocardial infarction.J. Med. Biochem.2009281414510.2478/v10011‑008‑0029‑9
     [Google Scholar]
  7. DebreceniB. DebreceniL. Why do homocysteine-lowering B vitamin and antioxidant E vitamin supplementations appear to be ineffective in the prevention of cardiovascular diseases?Cardiovasc. Ther.201230422723310.1111/j.1755‑5922.2011.00266.x21884001
     [Google Scholar]
  8. AbrahamJ.M. ChoL. The homocysteine hypothesis: Still relevant to the prevention and treatment of cardiovascular disease?Cleve. Clin. J. Med.2010771291191810.3949/ccjm.77a.1003621147945
     [Google Scholar]
  9. PengH. ManC. XuJ. FanY. Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: A meta-analysis of prospective studies.J. Zhejiang Univ. Sci. B2015161788610.1631/jzus.B140018325559959
     [Google Scholar]
  10. García-FernándezE. Rico-CabanasL. RosgaardN. EstruchR. Bach-FaigA. Mediterranean diet and cardiodiabesity: A review.Nutrients2014693474350010.3390/nu609347425192027
     [Google Scholar]
  11. LewisS.J. EbrahimS. SmithG.D. Meta-analysis of MTHFR 677C→ T polymorphism and coronary heart disease: Does totality of evidence support causal role for homocysteine and preventive potential of folate?BMJ20053317524105310.1136/bmj.38611.658947.5516216822
     [Google Scholar]
  12. Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis.JAMA2002288162015202210.1001/jama.288.16.201512387654
     [Google Scholar]
  13. RefsumH. NurkE. David SmithA. UelandP.M. GjesdalC.G. BjellandI. TverdalA. TellG.S. NygårdO. VollsetS.E. The Hordaland Homocysteine Study: A community-based study of homocysteine, its determinants, and associations with disease.J. Nutr.20061366Suppl.1731S1740S10.1093/jn/136.6.1731S16702348
     [Google Scholar]
  14. IsoH. MoriyamaY. SatoS. KitamuraA. TanigawaT. YamagishiK. ImanoH. OhiraT. OkamuraT. NaitoY. ShimamotoT. Serum total homocysteine concentrations and risk of stroke and its subtypes in Japanese.Circulation2004109222766277210.1161/01.CIR.0000131942.77635.2D15159287
     [Google Scholar]
  15. MenottiA. PudduP.E. MaianiG. CatastaG. Cardiovascular and other causes of death as a function of lifestyle habits in a quasi extinct middle-aged male population. A 50-year follow-up study.Int. J. Cardiol.201621017317810.1016/j.ijcard.2016.02.11526962972
     [Google Scholar]
  16. BostomA.G. RosenbergI.H. SilbershatzH. JacquesP.F. SelhubJ. D’AgostinoR.B. WilsonP.W.F. WolfP.A. Nonfasting plasma total homocysteine levels and stroke incidence in elderly persons: The Framingham Study.Ann. Intern. Med.1999131535235510.7326/0003‑4819‑131‑5‑199909070‑0000610475888
     [Google Scholar]
  17. ZhangZ. GuX. FangX. TangZ. GuanS. LiuH. WuX. WangC. ZhaoY. Homocysteine and the risk of cardiovascular events and all-cause death in elderly population: A community-based prospective cohort study.Ther. Clin. Risk Manag.20201647148110.2147/TCRM.S23949632547044
     [Google Scholar]
  18. BotsM.L. LaunerL.J. LindemansJ. HoesA.W. HofmanA. WittemanJ.C.M. KoudstaalP.J. GrobbeeD.E. Homocysteine and short- term risk of myocardial infarction and stroke in the elderly: the Rotterdam Study.Arch. Intern. Med.19991591384410.1001/archinte.159.1.389892328
     [Google Scholar]
  19. AndersonJ.L. MuhlesteinJ.B. HorneB.D. CarlquistJ.F. BairT.L. MadsenT.E. PearsonR.R. Plasma homocysteine predicts mortality independently of traditional risk factors and C-reactive protein in patients with angiographically defined coronary artery disease.Circulation2000102111227123210.1161/01.CIR.102.11.122710982535
     [Google Scholar]
  20. BarnabéA. AléssioA.C.M. BittarL.F. de Moraes MazettoB. BicudoA.M. de PaulaE.V. HöehrN.F. Annichino-BizzacchiJ.M. Folate, vitamin B12 and homocysteine status in the post-folic acid fortification era in different subgroups of the Brazilian population attended to at a public health care center.Nutr. J.20151411910.1186/s12937‑015‑0006‑325886278
     [Google Scholar]
  21. RothG.A. MensahG.A. JohnsonC.O. AddoloratoG. AmmiratiE. BaddourL.M. BarengoN.C. BeatonA.Z. BenjaminE.J. BenzigerC.P. BonnyA. BrauerM. BrodmannM. CahillT.J. CarapetisJ. CatapanoA.L. ChughS.S. CooperL.T. CoreshJ. CriquiM. DeCleeneN. EagleK.A. Emmons-BellS. FeiginV.L. Fernández-SolàJ. FowkesG. GakidouE. GrundyS.M. HeF.J. HowardG. HuF. InkerL. KarthikeyanG. KassebaumN. KoroshetzW. LavieC. Lloyd-JonesD. LuH.S. MirijelloA. TemesgenA.M. MokdadA. MoranA.E. MuntnerP. NarulaJ. NealB. NtsekheM. Moraes de OliveiraG. OttoC. OwolabiM. PrattM. RajagopalanS. ReitsmaM. RibeiroA.L.P. RigottiN. RodgersA. SableC. ShakilS. Sliwa-HahnleK. StarkB. SundströmJ. TimpelP. TleyjehI.M. ValgimigliM. VosT. WheltonP.K. YacoubM. ZuhlkeL. MurrayC. FusterV. RothG.A. MensahG.A. JohnsonC.O. AddoloratoG. AmmiratiE. BaddourL.M. BarengoN.C. BeatonA. BenjaminE.J. BenzigerC.P. BonnyA. BrauerM. BrodmannM. CahillT.J. CarapetisJ.R. CatapanoA.L. ChughS. CooperL.T. CoreshJ. CriquiM.H. DeCleeneN.K. EagleK.A. Emmons-BellS. FeiginV.L. Fernández-SolaJ. FowkesF.G.R. GakidouE. GrundyS.M. HeF.J. HowardG. HuF. InkerL. KarthikeyanG. KassebaumN.J. KoroshetzW.J. LavieC. Lloyd-JonesD. LuH.S. MirijelloA. MisganawA.T. MokdadA.H. MoranA.E. MuntnerP. NarulaJ. NealB. NtsekheM. OliveiraG.M.M. OttoC.M. OwolabiM.O. PrattM. RajagopalanS. ReitsmaM.B. RibeiroA.L.P. RigottiN.A. RodgersA. SableC.A. ShakilS.S. SliwaK. StarkB.A. SundströmJ. TimpelP. TleyjehI.I. ValgimigliM. VosT. WheltonP.K. YacoubM. ZuhlkeL.J. Abbasi-KangevariM. AbdiA. AbediA. AboyansV. AbrhaW.A. Abu-GharbiehE. AbushoukA.I. AcharyaD. AdairT. AdebayoO.M. AdemiZ. AdvaniS.M. AfshariK. AfshinA. AgarwalG. AgasthiP. AhmadS. AhmadiS. AhmedM.B. AjiB. AkaluY. Akande-SholabiW. AkliluA. AkunnaC.J. AlahdabF. Al-EyadhyA. AlhabibK.F. AlifS.M. AlipourV. AljunidS.M. AllaF. Almasi-HashianiA. AlmustanyirS. Al-RaddadiR.M. AmegahA.K. AminiS. AminorroayaA. AmuH. AmugsiD.A. AncuceanuR. AnderliniD. AndreiT. AndreiC.L. Ansari-MoghaddamA. AntenehZ.A. AntonazzoI.C. AntonyB. AnwerR. AppiahL.T. ArablooJ. ÄrnlövJ. ArtantiK.D. AtaroZ. AusloosM. Avila-BurgosL. AwanA.T. AwokeM.A. AyeleH.T. AyzaM.A. AzariS. BD.B. BaheiraeiN. BaigA.A. BakhtiariA. BanachM. BanikP.C. BaptistaE.A. BarbozaM.A. BaruaL. BasuS. BediN. BéjotY. BennettD.A. BensenorI.M. BermanA.E. BezabihY.M. BhagavathulaA.S. BhaskarS. BhattacharyyaK. BijaniA. BikbovB. BirhanuM.M. BoloorA. BrantL.C. BrennerH. BrikoN.I. ButtZ.A. Caetano dos SantosF.L. CahillL.E. Cahuana-HurtadoL. CámeraL.A. Campos-NonatoI.R. Cantu-BritoC. CarJ. CarreroJ.J. CarvalhoF. Castañeda-OrjuelaC.A. Catalá-LópezF. CerinE. CharanJ. ChattuV.K. ChenS. ChinK.L. ChoiJ-Y.J. ChuD-T. ChungS-C. CirilloM. CoffeyS. ContiS. CostaV.M. CundiffD.K. DadrasO. DagnewB. DaiX. DamascenoA.A.M. DandonaL. DandonaR. DavletovK. De la Cruz-GóngoraV. De la HozF.P. De NeveJ-W. Denova-GutiérrezE. Derbew MollaM. DersehB.T. DesaiR. DeuschlG. DharmaratneS.D. DhimalM. DhunganaR.R. DianatinasabM. DiazD. DjalaliniaS. DokovaK. DouiriA. DuncanB.B. DuraesA.R. EaganA.W. EbtehajS. EftekhariA. EftekharzadehS. EkholuenetaleM. El NahasN. ElgendyI.Y. ElhadiM. El-JaafaryS.I. EsteghamatiS. EtissoA.E. EyawoO. FadhilI. FaraonE.J.A. FarisP.S. FarwatiM. FarzadfarF. FernandesE. Fernandez PrendesC. FerraraP. FilipI. FischerF. FloodD. FukumotoT. GadM.M. GaidhaneS. GanjiM. GargJ. GebreA.K. GebregiorgisB.G. GebregzabiherK.Z. GebremeskelG.G. GetacherL. ObsaA.G. GhajarA. GhashghaeeA. GhithN. GiampaoliS. GilaniS.A. GillP.S. GillumR.F. GlushkovaE.V. GnedovskayaE.V. GolechhaM. GonfaK.B. GoudarzianA.H. GoulartA.C. GuadamuzJ.S. GuhaA. GuoY. GuptaR. HachinskiV. Hafezi-NejadN. HaileT.G. HamadehR.R. HamidiS. HankeyG.J. HargonoA. HartonoR.K. HashemianM. HashiA. HassanS. HassenH.Y. HavmoellerR.J. HayS.I. HayatK. HeidariG. HerteliuC. HollaR. HosseiniM. HosseinzadehM. HostiucM. HostiucS. HousehM. HuangJ. HumayunA. IavicoliI. IbenemeC.U. IbitoyeS.E. IlesanmiO.S. IlicI.M. IlicM.D. IqbalU. IrvaniS.S.N. IslamS.M.S. IslamR.M. IsoH. IwagamiM. JainV. JavaheriT. JayapalS.K. JayaramS. JayawardenaR. JeemonP. JhaR.P. JonasJ.B. JonnagaddalaJ. JoukarF. JozwiakJ.J. JürissonM. KabirA. KahlonT. KalaniR. KalhorR. KamathA. KamelI. KandelH. KandelA. KarchA. KasaA.S. KatotoP.D.M.C. KayodeG.A. KhaderY.S. KhammarniaM. KhanM.S. KhanM.N. KhanM. KhanE.A. KhatabK. KibriaG.M.A. KimY.J. KimG.R. KimokotiR.W. KisaS. KisaA. KivimäkiM. KolteD. KoolivandA. KorshunovV.A. Koulmane LaxminarayanaS.L. KoyanagiA. KrishanK. KrishnamoorthyV. Kuate DefoB. Kucuk BicerB. KulkarniV. KumarG.A. KumarN. KurmiO.P. KusumaD. KwanG.F. La VecchiaC. LaceyB. LallukkaT. LanQ. LasradoS. LassiZ.S. LauriolaP. LawrenceW.R. LaxmaiahA. LeGrandK.E. LiM-C. LiB. LiS. LimS.S. LimL-L. LinH. LinZ. LinR-T. LiuX. LopezA.D. LorkowskiS. LotufoP.A. LugoA. MN.K. MadottoF. MahmoudiM. MajeedA. MalekzadehR. MalikA.A. MamunA.A. ManafiN. MansourniaM.A. MantovaniL.G. MartiniS. MathurM.R. MazzagliaG. MehataS. MehndirattaM.M. MeierT. MenezesR.G. MeretojaA. MestrovicT. MiazgowskiB. MiazgowskiT. MichalekI.M. MillerT.R. MirrakhimovE.M. MirzaeiH. MoazenB. MoghadaszadehM. MohammadY. MohammadD.K. MohammedS. MohammedM.A. MokhayeriY. MolokhiaM. MontasirA.A. MoradiG. MoradzadehR. MoragaP. MorawskaL. Moreno VelásquezI. MorzeJ. MubarikS. MuruetW. MusaK.I. NagarajanA.J. NaliniM. NangiaV. NaqviA.A. Narasimha SwamyS. NascimentoB.R. NayakV.C. NazariJ. NazarzadehM. NegoiR.I. Neupane KandelS. NguyenH.L.T. NixonM.R. NorrvingB. NoubiapJ.J. NoutheB.E. NowakC. OdukoyaO.O. OgboF.A. OlagunjuA.T. OrruH. OrtizA. OstroffS.M. PadubidriJ.R. PalladinoR. PanaA. Panda-JonasS. ParekhU. ParkE-C. ParviziM. Pashazadeh KanF. PatelU.K. PathakM. PaudelR. PepitoV.C.F. PerianayagamA. PericoN. PhamH.Q. PilgrimT. PiradovM.A. PishgarF. PodderV. PolibinR.V. PourshamsA. PribadiD.R.A. RabieeN. RabieeM. RadfarA. RafieiA. RahimF. Rahimi-MovagharV. Ur RahmanM.H. RahmanM.A. RahmaniA.M. RakovacI. RamP. RamalingamS. RanaJ. RanasingheP. RaoS.J. RathiP. RawalL. RawasiaW.F. RawassizadehR. RemuzziG. RenzahoA.M.N. RezapourA. RiahiS.M. Roberts-ThomsonR.L. RoeverL. RohloffP. RomoliM. RoshandelG. RwegereraG.M. SaadatagahS. Saber-AyadM.M. SabourS. SaccoS. SadeghiM. Saeedi MoghaddamS. SafariS. SahebkarA. SalehiS. SalimzadehH. SamaeiM. SamyA.M. SantosI.S. Santric-MilicevicM.M. SarrafzadeganN. SarveazadA. SathishT. SawhneyM. SaylanM. SchmidtM.I. SchutteA.E. SenthilkumaranS. SepanlouS.G. ShaF. ShahabiS. ShahidI. ShaikhM.A. ShamaliM. ShamsizadehM. ShawonM.S.R. SheikhA. ShigematsuM. ShinM-J. ShinJ.I. ShiriR. ShiueI. ShuvalK. SiabaniS. SiddiqiT.J. SilvaD.A.S. SinghJ.A. MtechA.S. SkryabinV.Y. SkryabinaA.A. SoheiliA. SpurlockE.E. StockfeltL. StorteckyS. StrangesS. Suliankatchi AbdulkaderR. TadbiriH. TadesseE.G. TadesseD.B. TajdiniM. TariqujjamanM. TeklehaimanotB.F. TemsahM-H. TesemaA.K. ThakurB. ThankappanK.R. ThaparR. ThriftA.G. TimalsinaB. TonelliM. TouvierM. Tovani-PaloneM.R. TripathiA. TripathyJ.P. TruelsenT.C. TsegayG.M. TsegayeG.W. TsilimparisN. TusaB.S. TyrovolasS. UmapathiK.K. UnimB. UnnikrishnanB. UsmanM.S. VaduganathanM. ValdezP.R. VasankariT.J. VelazquezD.Z. VenketasubramanianN. VuG.T. VujcicI.S. WaheedY. WangY. WangF. WeiJ. WeintraubR.G. WeldemariamA.H. WestermanR. WinklerA.S. WiysongeC.S. WolfeC.D.A. WubishetB.L. XuG. YadollahpourA. YamagishiK. YanL.L. YandrapalliS. YanoY. YatsuyaH. YeheyisT.Y. YeshawY. YilgwanC.S. YonemotoN. YuC. YusefzadehH. ZachariahG. ZamanS.B. ZamanM.S. ZamanianM. ZandR. ZandifarA. ZarghiA. ZastrozhinM.S. ZastrozhinaA. ZhangZ-J. ZhangY. ZhangW. ZhongC. ZouZ. ZunigaY.M.H. MurrayC.J.L. FusterV. GBD-NHLBI-JACC Global Burden of Cardiovascular Diseases Writing Group Global burden of cardiovascular diseases and risk factors, 1990–2019.J. Am. Coll. Cardiol.202076252982302110.1016/j.jacc.2020.11.01033309175
     [Google Scholar]
  22. DebreceniB. DebreceniL. The role of homocysteine-lowering B-vitamins in the primary prevention of cardiovascular disease.Cardiovasc. Ther.201432313013810.1111/1755‑5922.1206424571382
     [Google Scholar]
  23. RimmE.B. WillettW.C. HuF.B. SampsonL. ColditzG.A. MansonJ.E. HennekensC. StampferM.J. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.JAMA1998279535936410.1001/jama.279.5.3599459468
     [Google Scholar]
  24. KayeA.D. JehaG.M. PhamA.D. FullerM.C. LernerZ.I. SibleyG.T. CornettE.M. UritsI. ViswanathO. KevilC.G. Folic acid supplementation in patients with elevated homocysteine levels.Adv. Ther.202037104149416410.1007/s12325‑020‑01474‑z32845472
     [Google Scholar]
  25. BaloghE. BereczkyZ. KatonaÉ. KőszegiZ. ÉdesI. MuszbekL. CzurigaI. Interaction between homocysteine and lipoprotein(a) increases the prevalence of coronary artery disease/myocardial infarction in women: A case-control study.Thromb. Res.2012129213313810.1016/j.thromres.2011.07.00121803402
     [Google Scholar]
  26. BalintB. JepchumbaV.K. GuéantJ.L. Guéant-RodriguezR.M. Mechanisms of homocysteine-induced damage to the endothelial, medial and adventitial layers of the arterial wall.Biochimie202017310010610.1016/j.biochi.2020.02.01232105811
     [Google Scholar]
  27. ArmitageJ.M. BowmanL. ClarkeR.J. WallendszusK. BulbuliaR. RahimiK. HaynesR. ParishS. SleightP. PetoR. CollinsR. Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group Effects of homocysteine-lowering with folic acid plus vitamin B12 vs. placebo on mortality and major morbidity in myocardial infarction survivors: A randomized trial.JAMA2010303242486249410.1001/jama.2010.84020571015
     [Google Scholar]
  28. YangQ. HeG.W. Imbalance of homocysteine and H2S: Significance, mechanisms, and therapeutic promise in vascular injury.Oxid. Med. Cell. Longev.2019201911110.1155/2019/762967331885816
     [Google Scholar]
  29. YuanS. MasonA.M. CarterP. BurgessS. LarssonS.C. Homocysteine, B vitamins, and cardiovascular disease: A mendelian randomization study.BMC Med.20211919710.1186/s12916‑021‑01977‑833888102
     [Google Scholar]
  30. MenottiA. PudduP.E. Can we still learn from the Seven Countries Study?Curr. Opin. Lipidol.201829431331710.1097/MOL.000000000000052029708924
     [Google Scholar]
  31. DesaiC.K. HuangJ. LokhandwalaA. FernandezA. RiazI.B. AlpertJ.S. The role of vitamin supplementation in the prevention of cardiovascular disease events.Clin. Cardiol.201437957658110.1002/clc.2229924863141
     [Google Scholar]
  32. HoeyL. McNultyH. AskinN. DunneA. WardM. PentievaK. StrainJ.J. MolloyA.M. FlynnC.A. ScottJ.M. Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults.Am. J. Clin. Nutr.20078651405141310.1093/ajcn/86.5.140517991653
     [Google Scholar]
  33. FengY. KangK. XueQ. ChenY. WangW. CaoJ. Value of plasma homocysteine to predict stroke, cardiovascular diseases, and new-onset hypertension.Medicine (Baltimore)20209934e2154110.1097/MD.000000000002154132846763
     [Google Scholar]
  34. FitzpatrickA.L. KronmalR.A. KimuraM. GardnerJ.P. PsatyB.M. JennyN.S. TracyR.P. HardikarS. AvivA. Leukocyte telomere length and mortality in the Cardiovascular Health Study.J. Gerontol. A Biol. Sci. Med. Sci.201166A442142910.1093/gerona/glq22421289018
     [Google Scholar]
  35. HankeyG.J. EikelboomJ.W. Homocysteine and vascular disease.Lancet1999354917640741310.1016/S0140‑6736(98)11058‑910437885
     [Google Scholar]
  36. PuscedduI. HerrmannW. KleberM.E. ScharnaglH. HoffmannM.M. Winklhofer-RoobB.M. MärzW. HerrmannM. Subclinical inflammation, telomere shortening, homocysteine, vitamin B6, and mortality: The Ludwigshafen Risk and Cardiovascular Health Study.Eur. J. Nutr.20205941399141110.1007/s00394‑019‑01993‑831129702
     [Google Scholar]
  37. McCullyK.S. Homocysteine and vascular disease.Nat. Med.19962438638910.1038/nm0496‑3868597939
     [Google Scholar]
  38. KromhoutD. MenottiA. Alberti-FidanzaA. PudduP.E. HollmanP. KafatosA. TolonenH. AdachiH. JacobsD.R.Jr Comparative ecologic relationships of saturated fat, sucrose, food groups, and a Mediterranean food pattern score to 50-year coronary heart disease mortality rates among 16 cohorts of the Seven Countries Study.Eur. J. Clin. Nutr.20187281103111010.1038/s41430‑018‑0183‑129769748
     [Google Scholar]
  39. MalinowM.R. DuellP.B. HessD.L. AndersonP.H. KrugerW.D. PhillipsonB.E. GluckmanR.A. BlockP.C. UpsonB.M. Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease.N. Engl. J. Med.1998338151009101510.1056/NEJM1998040933815019535664
     [Google Scholar]
  40. Research on the health of the population of Serbia in 2019.2020Available from: https://www-stat-gov-rs.translate.goog/sr-latn/vesti/20210429-istrazivanje-zdravlja-stan/?s=1810&_x_tr_sl=sr&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=sc (accessed on 20-8-2024)
  41. Ružić P. Nutrition and physical activity - experiences, new trends and recommendations.Food. Nutrit.1997481-4514
     [Google Scholar]
  42. NygårdO. NordrehaugJ.E. RefsumH. UelandP.M. FarstadM. VollsetS.E. Plasma homocysteine levels and mortality in patients with coronary artery disease.N. Engl. J. Med.1997337423023710.1056/NEJM1997072433704039227928
     [Google Scholar]
  43. MalinowM.R. BostomA.G. KraussR.M. Homocysteine, diet and cardiovascular diseases.Circulation199999117818210.1161/01.CIR.99.1.1789884399
     [Google Scholar]
  44. WangD.D. LiY. BhupathirajuS.N. RosnerB.A. SunQ. GiovannucciE.L. RimmE.B. MansonJ.E. WillettW.C. StampferM.J. HuF.B. Fruit and vegetable intake and mortality.Circulation2021143171642165410.1161/CIRCULATIONAHA.120.04899633641343
     [Google Scholar]
  45. McCullyK.S. Hyperhomocysteinemia and arteriosclerosis: Historical perspectives.Clin. Chem. Lab. Med.2005431098098610.1515/CCLM.2005.17216197285
     [Google Scholar]
  46. La VerdeM. MulèS. ZappalàG. PriviteraG. MaugeriG. PecoraF. MarranzanoM. Higher adherence to the Mediterranean diet is inversely associated with having hypertension: Is low salt intake a mediating factor?Int. J. Food Sci. Nutr.201869223524410.1080/09637486.2017.135094128705075
     [Google Scholar]
  47. MenottiA. PudduP.E. LantiM. MaianiG. CatastaG. Alberti FidanzaA. Lifestyle habits and mortality from all and specific causes of death: 40-year follow-up in the Italian rural areas of the seven countries study.J. Nutr. Health Aging201418331432110.1007/s12603‑013‑0392‑124626761
     [Google Scholar]
  48. WelshG.N. LoscalzoJ. Homocystein and aterothrombosis.N. Engl. J. Med.199833819421950
     [Google Scholar]
  49. ArinaC. AmirD. SiregarY. Correlation between homocysteine and dyslipidemia in ishaemic stroke patients with and without hypertension.Earth. Environ. Sci.201813001200510.1088/1755‑1315/130/1/012005
     [Google Scholar]
  50. SchnyderG. RoffiM. PinR. FlammerY. LangeH. EberliF.R. MeierB. TuriZ.G. HessO.M. Decreased rate of coronary restenosis after lowering of plasma homocysteine levels.N. Engl. J. Med.2001345221593160010.1056/NEJMoa01136411757505
     [Google Scholar]
  51. MenottiA. PudduP.E. How the Seven Countries Study contributed to the definition and development of the Mediterranean diet concept: A 50-year journey.Nutrit. Metab. Cardiovascul. Dis.2015253245252
     [Google Scholar]
  52. SadeghianS. FallahiF. SalarifarM. DavoodiG. MahmoodianM. FallahN. DarvishS. KarimiA. Tehran Heart Center Homocysteine, vitamin B12 and folate levels in premature coronary artery disease.BMC Cardiovasc. Disord.2006613810.1186/1471‑2261‑6‑3817002799
     [Google Scholar]
  53. GrundyS.M. PasternakR. GreenlandP. SmithS.Jr FusterV. Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations.J. Am. Coll. Cardiol.19993441348135910.1016/S0735‑1097(99)00387‑310520820
     [Google Scholar]
  54. Martí-CarvajalA.J. SolàI. LathyrisD. DayerM. Homocysteine-lowering interventions for preventing cardiovascular events.Cochrane Database Syst. Rev.201788CD00661228816346
     [Google Scholar]
  55. PerkJ. De BackerG. GohlkeH. GrahamI. ReinerZ. VerschurenM. AlbusC. BenlianP. BoysenG. CifkovaR. DeatonC. EbrahimS. FisherM. GermanoG. HobbsR. HoesA. KaradenizS. MezzaniA. PrescottE. RydenL. SchererM. SyvänneM. Scholte Op ReimerW.J.M. VrintsC. WoodD. ZamoranoJ.L. ZannadF. CooneyM.T. BaxJ. BaumgartnerH. CeconiC. DeanV. DeatonC. FagardR. Funck-BrentanoC. HasdaiD. HoesA. KirchhofP. KnuutiJ. KolhP. McDonaghT. MoulinC. PopescuB.A. ReinerZ. SechtemU. SirnesP.A. TenderaM. TorbickiA. VahanianA. WindeckerS. Funck-BrentanoC. SirnesP.A. AboyansV. EzquerraE.A. BaigentC. BrotonsC. BurellG. CerielloA. De SutterJ. DeckersJ. Del PratoS. DienerH-C. FitzsimonsD. FrasZ. HambrechtR. JankowskiP. KeilU. KirbyM. LarsenM.L. ManciaG. ManolisA.J. McMurrayJ. PajakA. ParkhomenkoA. RallidisL. RigoF. RochaE. RuilopeL.M. van der VeldeE. VanuzzoD. ViigimaaM. VolpeM. WiklundO. WolpertC. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts) Developed with the Special Contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR).Eur. Heart J.201233131635170110.1093/eurheartj/ehs09222555213
     [Google Scholar]
  56. HongX. WardP. WoodmanR. Is homocysteine an independent predictor of hypertension? A case-control study in an eldery population.Int. J. Clin. Exp. Med.201710471297136
     [Google Scholar]
  57. RodrigoR. PassalacquaW. ArayaJ. OrellanaM. RiveraG. Homocysteine and essential hypertension.J. Clin. Pharmacol.200343121299130610.1177/009127000325819014615465
     [Google Scholar]
  58. SunP. WangQ. ZhangY. Association between homocysteine level and blood pressure trait among Tibetans. A cross-section study in China.Medicine20199827e16085
     [Google Scholar]
  59. McMahonJ.A. SkeaffC.M. WilliamsS.M. GreenT.J. Lowering homocysteine with B vitamins has no effect on blood pressure in older adults.J. Nutr.200713751183118710.1093/jn/137.5.118317449579
     [Google Scholar]
  60. HanL. WuQ. WangC. HaoY. ZhaoJ. ZhangL. FanR. LiuY. LiR. ChenZ. ZhangT. ChenS. MaJ. LiuS. PengX. DuanS. Homocystein, ishaemic stroke and coronary heart disease in hypertensive patients: A population - based prospective cohort study.Stroke20154671777178610.1161/STROKEAHA.115.00911126038522
     [Google Scholar]
  61. CenkoE. Clinical determinants of ischemic heart disease in Eastern Europe.Lancet202333100698
     [Google Scholar]
  62. FinkelsteinJ.D. MartinJ.J. Homocysteine.Int. J. Biochem. Cell Biol.200032438538910.1016/S1357‑2725(99)00138‑710762063
     [Google Scholar]
  63. HermannA. SitdikovaG. Homocysteine: Biochemistry, molecular biology and role in disease.Biomolecules202111573710.3390/biom1105073734063494
     [Google Scholar]
  64. KaplanP. TatarkovaZ. SivonovaM.K. RacayP. LehotskyJ. Homocysteine and mitochondria in cardiovascular and cerebrovascular systems.Int. J. Mol. Sci.20202120769810.3390/ijms2120769833080955
     [Google Scholar]
  65. HashimotoT. ShinoharaY. HasegawaH. Homocysteine metabolism.Yakugaku Zasshi2007127101579159210.1248/yakushi.127.157917917419
     [Google Scholar]
  66. WijekoonE.P. BrosnanM.E. BrosnanJ.T. Homocysteine metabolism in diabetes.Biochem. Soc. Trans.20073551175117910.1042/BST035117517956306
     [Google Scholar]
  67. LuZ.H. LiJ. LiX.L. DingM. MaoC.J. ZhuX.Y. LiuC.F. Hypertension with hyperhomocysteinemia increases the risk of early cognitive impairment after first-ever ischemic stroke.Eur. Neurol.2019824-6758510.1159/00050470431825940
     [Google Scholar]
  68. BurgiadiniR. CenkoE. YoonJ. Traditional risk factors and premature acute coronary syndromes in Southeastern Europe: A multinational cohort study.Lancet Reg. Health Eur.2024202310082410.1016/j/lanepe
     [Google Scholar]
/content/journals/cpd/10.2174/0113816128326875240916050251
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Homocysteine Blood Levels and Mandatory Folic Acid Fortification in Serbia
Curr. Pharm. Des. 31, 484 (2025); https://doi.org/10.2174/0113816128326875240916050251
/content/journals/cpd/10.2174/0113816128326875240916050251
/content/journals/cpd/10.2174/0113816128326875240916050251
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  • Article Type:     Research Article
Keyword(s): coronary artery disease; Homocysteine; hypertension; nutrition, folic acid, vitamin B12

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