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Volume 30, Issue 39
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Background

Sirolimus, one of the immunosuppressive drugs administered to renal transplant recipients, is metabolized by cytochrome P450 (CYP) 3A5. Accordingly, polymorphism is a genetic factor affecting sirolimus pharmacokinetics (PK). Therefore, we conducted a systematic review and meta-analysis on the association between sirolimus PK and polymorphism.

Methods

We searched for studies published up to 13 June 2024 from PubMed, Embase, Cochrane Library, and Web of Science. We reviewed studies on the relationship between polymorphism and weight-adjusted trough concentration/dose (C/D) ratio and dosage of sirolimus in renal transplant recipients, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We evaluated mean differences (MDs) and 95% confidence intervals (CIs).

Results

A total of seven studies were included. The weight-adjusted C/D ratio of sirolimus was significantly higher in patients with the rather than or genotype (MD 95.27 ng/mL per mg/kg; 95% CI: 58.06, 132.47; I2 = 74%; < 0.00001). Also, the weight-adjusted dosage of sirolimus was significantly lower in patients with the rather than or genotype (MD -2.60 × 10-3 mg/kg; 95% CI: -4.52, -0.69; I2 = 44%; = 0.008).

Conclusion

Our meta-analysis showed a significant effect for the genotype on weight-adjusted C/D ratio and dosage of sirolimus in adult renal transplant recipients.

PROSPERO Register Number

CRD42022354330.

© 2024 Bentham Science Publishers
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Effects of CYP3A5 Genetic Polymorphisms on the Weight-adjusted through Concentration of Sirolimus in Renal Transplant Recipients: A Systematic Review and Meta-analysis
Curr. Pharm. Des. 30, 3108 (2024); https://doi.org/10.2174/0113816128324199240730093415
/content/journals/cpd/10.2174/0113816128324199240730093415
/content/journals/cpd/10.2174/0113816128324199240730093415
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  • Article Type:     Research Article
Keyword(s): Cytochrome P450 3A5; pharmacogenomics; pharmacokinetics; polymorphism; renal transplantation; sirolimus

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