Skip to content
2000
Volume 30, Issue 41
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

In recent years, microbial infections have emerged as a serious global health problem, necessitating the search for novel and effective treatments. Medicinal plants contain phytochemicals that can be used to prevent and treat various infections. Traditional medicinal practices have long relied on the healing properties of herbs, and Nepal is particularly rich in this knowledge. Bioactive compounds found in plants possess antibacterial, antifungal, and antiviral properties, making them a valuable resource for the fight against microbial infections. This review focuses on three medicinal plants native to Nepal, and , which contain potent antimicrobial phytochemicals. The traditional uses, bioactive components, and biological activities of these plants are discussed, providing valuable insights into their potential as natural remedies to combat microbial infections.

Loading

Article metrics loading...

/content/journals/cpd/10.2174/0113816128309718240822060114
2024-09-09
2025-01-30
Loading full text...

Full text loading...

References

  1. KunwarR.M. ShresthaK.P. BussmannR.W. Traditional herbal medicine in Far-west Nepal: A pharmacological appraisal.J. Ethnobiol. Ethnomed.2010613510.1186/1746‑4269‑6‑3521144003
    [Google Scholar]
  2. Ben-ShabatS. YarmolinskyL. PoratD. DahanA. Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies.Drug Deliv Transl Res.202010235436710.1007/s13346‑019‑00691‑6
    [Google Scholar]
  3. AtanasovA.G. ZotchevS.B. DirschV.M. SupuranC.T. Natural products in drug discovery: Advances and opportunities.Nat. Rev. Drug Discov.202120320021610.1038/s41573‑020‑00114‑z33510482
    [Google Scholar]
  4. MukhtarM. ArshadM. AhmadM. PomerantzR.J. WigdahlB. ParveenZ. Antiviral potentials of medicinal plants.Virus Res.2008131211112010.1016/j.virusres.2007.09.008
    [Google Scholar]
  5. GhildiyalR. PrakashV. ChaudharyV.K. GuptaV. GabraniR. Phytochemicals as antiviral agents: Recent updates.Plant-derived Bioactives2020Jan27929510.1007/978‑981‑15‑1761‑7_12
    [Google Scholar]
  6. Álvarez-MartínezF.J. Barrajón-CatalánE. Herranz-LópezM. MicolV. Antibacterial plant compounds, extracts and essential oils: An updated review on their effects and putative mechanisms of action.Phytomedicine20219015362610.1016/j.phymed.2021.15362634301463
    [Google Scholar]
  7. KaczmarekB. Tannic acid with antiviral and antibacterial activity as a promising component of biomaterials-A minireview.Materials (Basel)20201314322410.3390/ma1314322432698426
    [Google Scholar]
  8. KhamenehB. IranshahyM. SoheiliV. Fazly BazzazB.S. Review on plant antimicrobials: A mechanistic viewpoint.Antimicrob. Resist. Infect. Control20198111810.1186/s13756‑019‑0559‑631346459
    [Google Scholar]
  9. KhareT. AnandU. DeyA. AssarafY.G. ChenZ.S. LiuZ. KumarV. Exploring phytochemicals for combating antibiotic resistance in microbial pathogens.Front. Pharmacol.20211272072610.3389/fphar.2021.72072634366872
    [Google Scholar]
  10. SuganyaT. PackiavathyI.A.S.V. AseervathamG.S.B. CarmonaA. RashmiV. MariappanS. DeviN.R. AnanthD.A. Tackling multiple-drug-resistant bacteria with conventional and complex phytochemicals.Front. Cell. Infect. Microbiol.20221288383910.3389/fcimb.2022.88383935846771
    [Google Scholar]
  11. KhamenehB. EskinN. A. M. IranshahyM. Fazly BazzazB. S. Phytochemicals: A promising weapon in the arsenal against antibiotic-resistant bacteria.Antibiotics (Basel).2021109104410.3390/antibiotics10091044
    [Google Scholar]
  12. LoweH. SteeleB. BryantJ. FouadE. ToyangN. NgwaW. Antiviral activity of Jamaican medicinal plants and isolated bioactive compounds.Molecules202126360710.3390/molecules26030607.
    [Google Scholar]
  13. GhanashyamS. Surendra JoshiR. BhadurG.M. ChandraC.H. Package of Practices for Promoting Climate Resilient Cardamom Value Chains in Nepal2017Available from: https://researchgate.net/publication/326506616_Package_of_Practices_for_Promoting_Climate_Resilient_Cardamom_Value_Chains_in_Nepal
    [Google Scholar]
  14. KhanalA. DevkotaH.P. KaundinnyayanaS. GyawaliP. AnandaR. AdhikariR. Culinary herbs and spices in Nepal: A review of their traditional uses, chemical constituents, and pharmacological activities.Ethnobot. Res. Appl.20212111810.32859/era.21.40.1‑18
    [Google Scholar]
  15. EklabyaS. RitaS. A Boon for mountain populations.Mt. Res. Dev.2000202108111
    [Google Scholar]
  16. BishtV.K. NegiJ.S. BhandariA.K. SundriyalR.C. Amomum subulatum Roxb: Traditional, phytochemical and biological activities-An overview.Afr. J. Agric. Res.20116245386539010.5897/AJAR11.745
    [Google Scholar]
  17. GautamN. BhattaraiR.R. KhanalB.K.S. OliP. Technology, chemistry and bioactive properties of large cardamom (Amomum subulatum Roxb.): An overview.Int. J. Appl. Sci. Biotechnol.20164213914910.3126/ijasbt.v4i2.15104
    [Google Scholar]
  18. ParveenU. JahangirU. MaazM. MujeebM. Biological and therapeutic uses of Amomum subulatum Roxb.EJBPS201851167176
    [Google Scholar]
  19. AlamA. SinghV. Composition and pharmacological activity of essential oils from two imported Amomum subulatum fruit samples.J. Taibah Univ. Med. Sci.202116223123910.1016/j.jtumed.2020.10.00733897328
    [Google Scholar]
  20. AlamA. VijenderS. PravejA. GudadeB.A. Morphological and molecular variations studies in high yielding cultivars of Amomum subulatum (Roxb.) collected from North-Eastern Part of India.Res. J. Biotechnol.202015108087 https://www.researchgate.net/publication/344457048_Morphological_and_Molecular_Variations_Studies_in_High_Yielding_Cultivars_of_Amomum_Subulatum_Roxb_Collected_from_North- Eastern_Part_of_India
    [Google Scholar]
  21. AlamK. PathakD. AnsariS.H. Evaluation of anti-inflammatory activity of Ammomum subulatum fruit extract.IJPSDR2011313537
    [Google Scholar]
  22. UmeshK. BrajeshK. AnilB. KumarY. Phytochemical investigation and comparison of antimicrobial screening of clove and cardamom.IJPSR2010112138147
    [Google Scholar]
  23. SinghB. SinghG. IsidorovV.A. SzczepaniakL. Chemistry, antifungal and antioxidant activities of cardamom (Amomum subulatum) essential oil and oleoresins.J. Essent. Oil Ther.200822940
    [Google Scholar]
  24. DhakalR. DihingiaA. AhmedR.S. GuptaD.D. SahuR.K. DuttaP. BharaliP. MannaP. SastryG.N. KalitaJ. Prophylactic and therapeutic potential of active phytoconstituents from Amomum subulatum Roxb.Food Front.202341608410.1002/fft2.184
    [Google Scholar]
  25. JafriM.A. FarahK. JavedK. SinghS. Evaluation of the gastric antiulcerogenic effect of large cardamom (fruits of Amomum subulatum Roxb).J. Ethnopharmacol.2001752-3899410.1016/S0378‑8741(00)00398‑611297839
    [Google Scholar]
  26. AlruhailiM.H. AlmuhayawiM.S. GattanH.S. AlharbiM.T. NagshabandiM.K. JaouniS.K.A. SelimS. AbdElgawadH. Insight into the phytochemical profile and antimicrobial activities of Amomum subulatum and Amomum xanthioides: An in vitro and in silico study.Front. Plant Sci.202314113696110.3389/fpls.2023.113696137152127
    [Google Scholar]
  27. Abdullah, Ahmad N, Tian W, et al. Recent advances in the extraction, chemical composition, therapeutic potential, and delivery of cardamom phytochemicals.Front. Nutr.20229102482010.3389/fnut.2022.102482036245491
    [Google Scholar]
  28. Abdullah, Algburi A, Asghar A, et al. Black cardamom essential oil prevents Escherichia coli O157:H7 and Salmonella typhimurium JSG 1748 biofilm formation through inhibition of quorum sensing.J. Food Sci. Technol.20215883183319110.1007/s13197‑020‑04821‑834294980
    [Google Scholar]
  29. NagA. VermaP. PaulS. KunduR. In silico analysis of the apoptotic and hpv inhibitory roles of some selected phytochemicals detected from the rhizomes of greater cardamom.Appl. Biochem. Biotechnol.2022194104867489110.1007/s12010‑022‑04006‑335670907
    [Google Scholar]
  30. AliS. NoreenA. QamarA. ZafarI. AinQ. NafidiH.A. Bin JardanY.A. BourhiaM. RashidS. SharmaR. Amomum subulatum: A treasure trove of anti-cancer compounds targeting TP53 protein using in vitro and in silico techniques.Front Chem.202311117436310.3389/fchem.2023.117436337206196
    [Google Scholar]
  31. KhatiwadaA. SubediA. DangolR. A review on status of production of large cardamom in Nepal and its marketing in national and global scenario.Malays. j. halal res.201921162110.2478/mjhr‑2019‑0004
    [Google Scholar]
  32. TibendaJ.J. YiQ. WangX. ZhaoQ. Review of phytomedicine, phytochemistry, ethnopharmacology, toxicology, and pharmacological activities of Cymbopogon genus.Front. Pharmacol.20221399791810.3389/fphar.2022.99791836105217
    [Google Scholar]
  33. PrasadC. SinghD. ShuklaO. SinghU.B. Cymbopogon jwarancusa -An important medicinal plant: A review. Pharm Innov J 2014; 3(6): 13-9. https://www.thepharmajournal.com/archives/2014/vol3issue6/PartA/10.1-267.pdf
  34. OpeyemiA. OpeoluwaO. PamelaR. BenedictaN-C. AdebolaO. 2015Cymbopogon species; Ethnopharmacology, phytochemistry and the pharmacological importance.Molecules.201520574385310.3390/molecules20057438.
    [Google Scholar]
  35. DuttaS. MundaS. LalM. BhattacharyyaP.R. A short review on chemical composition therapeutic use and enzyme inhibition activities of Cymbopogon species.Indian J. Sci. Technol.20169461-910.17485/ijst/2016/v9i46/87046
    [Google Scholar]
  36. BarfroshanY. MottaghipishehJ. MaghsoodlouM-T. DostiN. BeyzaeiH. Moghaddam ManeshM.R. VitaliniS. IritiM. Comparative study of bioactivities and chemical constituents of Cymbopogon jwarancusa subsp. Olivieri (Boiss.) Soenarko harvested in spring and winter.J. Essent. Oil-Bear. Plants20182141107111810.1080/0972060X.2018.1509023
    [Google Scholar]
  37. KumarA. BhattG. PandeyP. ChauhanA. UpadhyayR.K. SaikiaD. VermaR.S. ChanotiyaC.S. PadaliaR.C. Chemical characterization, antimicrobial and antioxidant evaluation of Cymbopogon jwarancusa (Jones) Schult. essential oil.J. Essent. Oil Res.202133435135810.1080/10412905.2021.1886186
    [Google Scholar]
  38. DarM.Y. ShahW.A. RatherM.A. QurishiY. HamidA. QurishiM.A. Chemical composition, in vitro cytotoxic and antioxidant activities of the essential oil and major constituents of Cymbopogon jawarancusa (Kashmir).Food Chem.201112941606161110.1016/j.foodchem.2011.06.016
    [Google Scholar]
  39. KumarA. JnaneshaA.C. LalR.K. Coppicing impact on the essential oil yield and its chemical composition of lemongrass cultivars of the genus Cymbopogon under the semi-arid region of South India.Acta Ecol. Sin.2023431202610.1016/j.chnaes.2021.05.005
    [Google Scholar]
  40. KumariR. KumarS. Cinnamomum: Review article of essential oil compounds, ethnobotany, antifungal and antibacterial effects.Open. Access. J. Sci.20193113-610.15406/oajs.2019.03.00121
    [Google Scholar]
  41. SatyalP. PaudelP. PoudelA. DosokyN.S. PokharelK.K. SetzerW.N. Bioactivities and compositional analyses of Cinnamomum essential oils from Nepal: C. camphora, C. tamala , and C. glaucescens .Nat. Prod. Commun.20138121934578X130080110.1177/1934578X130080123224555298
    [Google Scholar]
  42. PrakashB. SinghP. YadavS. SinghS.C. DubeyN.K. Safety profile assessment and efficacy of chemically characterized Cinnamomum glaucescens essential oil against storage fungi, insect, aflatoxin secretion and as antioxidant.Food Chem. Toxicol.20135316016710.1016/j.fct.2012.11.04423220615
    [Google Scholar]
  43. GyawaliR. Antibacterial and cytotoxic activities of high altitude essential oils from Nepalese Himalaya.J. Med. Plants Res.201371373874310.5897/JMPR11.1713
    [Google Scholar]
  44. TiwariS. UpadhyayN. SinghB.K. SinghV.K. DubeyN.K. Facile fabrication of nanoformulated Cinnamomum glaucescens essential oil as a novel green strategy to boost potency against food borne fungi, aflatoxin synthesis, and lipid oxidation.Food Bioprocess Technol.202215231933710.1007/s11947‑021‑02739‑3
    [Google Scholar]
/content/journals/cpd/10.2174/0113816128309718240822060114
Loading
/content/journals/cpd/10.2174/0113816128309718240822060114
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test