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Volume 30, Issue 16
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Self-nano Emulsifying Drug Delivery Systems (SNEDDS) are novel formulations that can enhance the solubility and bioavailability of poorly water-soluble drugs. SNEDDS are composed of lipids, surfactants, co-solvents, and drugs and can spontaneously form nanoemulsions when mixed with water under mild agitation. SNEDDS can be formulated as liquid or solid dosage forms and can improve drug absorption by increasing the interfacial area, protecting the drug from degradation, and facilitating lymphatic transport. SNEDDS is characterized by various parameters such as particle size, zeta potential, droplet morphology, emulsification efficiency, drug solubility, and stability. SNEDDS offers several advantages over conventional dosage forms, such as dose reduction, faster onset of action, reduced variability, versatility, and ease of formulation. However, SNEDDS also face some limitations and challenges, such as drug precipitation, cost-effectiveness, compatibility with capsule shells, and lack of predictive models. SNEDDS has a promising future in the field of pharmaceuticals, especially for personalized medicine and targeted drug delivery.

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2024-05-01
2025-01-10

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References

  1. NeubertR.H.H. Potentials of new nanocarriers for dermal and transdermal drug delivery.Eur. J. Pharm. Biopharm.20117711210.1016/j.ejpb.2010.11.00321111043
     [Google Scholar]
  2. TadrosT. IzquierdoP. EsquenaJ. SolansC. Formation and stability of nano-emulsions.Adv. Colloid Interface Sci.2004108-10930331810.1016/j.cis.2003.10.02315072948
     [Google Scholar]
  3. ConstantinidesP.P. ChaubalM.V. ShorrR. Advances in lipid nanodispersions for parenteral drug delivery and targeting.Adv. Drug Deliv. Rev.200860675776710.1016/j.addr.2007.10.01318096269
     [Google Scholar]
  4. DateA. NagarsenkerM. Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil.Int. J. Pharm.20073291-216617210.1016/j.ijpharm.2006.08.03817010543
     [Google Scholar]
  5. AlanderJ. WarnheimT. Model microemulsions containing vegetable oils part 1: Nonionic surfactant systems.J. Am. Oil Chem. Soc.198966111656166010.1007/BF02636197
     [Google Scholar]
  6. GroveM. PedersenG.P. NielsenJ.L. MüllertzA. Bioavailability of seocalcitol I: Relating solubility in biorelevant media with oral bioavailability in rats-effect of medium and long chain triglycerides.J. Pharm. Sci.20059481830183810.1002/jps.2040315986460
     [Google Scholar]
  7. DixitR.P. NagarsenkerM.S. Formulation and in vivo evaluation of self-nanoemulsifying granules for oral delivery of a combination of ezetimibe and simvastatin.Drug Dev. Ind. Pharm.200834121285129610.1080/0363904080207157018720144
     [Google Scholar]
  8. ColeE.T. CadéD. BenameurH. Challenges and opportunities in the encapsulation of liquid and semi-solid formulations into capsules for oral administration.Adv. Drug Deliv. Rev.200860674775610.1016/j.addr.2007.09.00918096270
     [Google Scholar]
  9. BowtleW.J. Materials, process, and manufacturing considerations for lipid-based hard-capsule formats.DRUGS.PHARMAC. SCI.200717079
     [Google Scholar]
  10. SinghB. SinghR. BandyopadhyayS. KapilR. GargB. Optimized nanoemulsifying systems with enhanced bioavailability of carvedilol.Colloids Surf. B Biointerfaces201310146547410.1016/j.colsurfb.2012.07.01723010056
     [Google Scholar]
  11. MuH. HolmR. MüllertzA. Lipid-based formulations for oral administration of poorly water-soluble drugs.Int. J. Pharm.2013453121522410.1016/j.ijpharm.2013.03.05423578826
     [Google Scholar]
  12. ShafiqS. ShakeelF. TalegaonkarS. AhmadF.J. KharR.K. AliM. Development and bioavailability assessment of ramipril nanoemulsion formulation.Eur. J. Pharm. Biopharm.200766222724310.1016/j.ejpb.2006.10.01417127045
     [Google Scholar]
  13. ShakeelF. IqbalM. EzzeldinE. Bioavailability enhancement and pharmacokinetic profile of an anticancer drug ibrutinib by self-nanoemulsifying drug delivery system.J. Pharm. Pharmacol.201668677278010.1111/jphp.1255027018771
     [Google Scholar]
  14. SinghB. BandopadhyayS. KapilR. SinghR. KatareO.P. Self-emulsifying drug delivery systems (SEDDS): Formulation development, characterization, and applications.Crit Rev Ther Drug Carrier Syst2009265
     [Google Scholar]
  15. NielsenF.S. PetersenK.B. MüllertzA. Bioavailability of probucol from lipid and surfactant based formulations in minipigs: Influence of droplet size and dietary state.Eur. J. Pharm. Biopharm.200869255356210.1016/j.ejpb.2007.12.02018294829
     [Google Scholar]
  16. RehmanF.U. ShahK.U. ShahS.U. KhanI.U. KhanG.M. KhanA. From nanoemulsions to self-nanoemulsions, with recent advances in self-nanoemulsifying drug delivery systems (SNEDDS).Expert Opin. Drug Deliv.201714111325134010.1080/17425247.2016.121846227485144
     [Google Scholar]
  17. KhanN. CraigD.Q.M. The influence of drug incorporation on the structure and release properties of solid dispersions in lipid matrices.J. Control. Release200393335536810.1016/j.jconrel.2003.09.00614644585
     [Google Scholar]
  18. BrubachJ.B. OllivonM. JanninV. MahlerB. BourgauxC. LesieurP. RoyP. Structural and thermal characterization of mono-and diacyl polyoxyethylene glycol by infrared spectroscopy and X-ray diffraction coupled to differential calorimetry.J. Phys. Chem. B200410846177211772910.1021/jp047989m
     [Google Scholar]
  19. XuS. DaiW.G. Drug precipitation inhibitors in supersaturable formulations.Int. J. Pharm.20134531364310.1016/j.ijpharm.2013.05.01323680727
     [Google Scholar]
  20. TangB. ChengG. GuJ.C. XuCH Development of solid self-emulsifying drug delivery systems: Preparation techniques and dosage forms.Drug Discov. Today20081313-1460661210.1016/j.drudis.2008.04.00618598917
     [Google Scholar]
  21. MilovićM. DjurišJ. DjekićL. VasiljevićD. IbrićS. Characterization and evaluation of solid self-microemulsifying drug delivery systems with porous carriers as systems for improved carbamazepine release.Int. J. Pharm.20124361-2586510.1016/j.ijpharm.2012.06.03222721847
     [Google Scholar]
/content/journals/cpd/10.2174/0113816128296705240327065131
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A Comprehensive Guide to the Development, Evaluation, and Future Prospects of Self-nanoemulsifying Drug Delivery Systems for Poorly Water-soluble Drugs
Curr. Pharm. Des. 30, 1211 (2024); https://doi.org/10.2174/0113816128296705240327065131
/content/journals/cpd/10.2174/0113816128296705240327065131
/content/journals/cpd/10.2174/0113816128296705240327065131
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  • Article Type:     Review Article
Keyword(s): bioavailability; nanoemulsion; self-emulsification; SNEDDS; solubility; water-soluble drugs

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