Current Pharmaceutical Biotechnology - Volume 25, Issue 11, 2024

Ongoing development in cosmetics is increasingly making use of probiotics, which are defined as “live microorganisms with health-enhancing properties mediated through ingestion or topical application to the host”. The observation that several bacterial strains augment normal processes of healthy tissue maintenance, particularly for the skin, has opened up new avenues for the use of bacterial strains in cosmetics. A princ Read More

Objectives: In the last decade, nanobiotechnology is emerging as a keen prudence area owing to its widespread applications in the medical field. In this context, zero-valent iron nanoparticles (nZVI) have garnered tremendous attention attributed to their cheap, non-toxic, excellent paramagnetic nature, extremely reactive surface, and dual oxidation state that makes them excellent antioxidants and free-radical scavengers. Facile Read More

CAR T-cell therapy is a promising approach for cancer treatment, utilizing a patient's own T-cells (autologous cell) or T-cells from a healthy donor (allogeneic cell) to target and destroy cancer cells. Over the last decade, significant advancements have been made in this field, including the development of novel CAR constructs, improved understanding of biology and mechanisms of action, and expanded clinical applications Read More

Introduction: The review presents the latest developments in the area of intranasal in situ delivery systems of immunobiological drugs (IBDs). Interest in intranasal administration for IBDs has increased significantly due to the COVID-19 pandemic. However, not only intranasal delivery of vaccines is developing, but also bacteriophages, interferons, etc. In situ systems that make a selective phase transition can be a modern Read More

There are several vaccines available for preventing various bacterial and viral infections, but still, there are many challenges that require the development of noninvasive, more efficient, and active vaccines. The advancement in biotechnological tools has provided safer antigens, such as nucleic acids, proteins etc., but due to their lower immunogenic property, adjuvants of stronger immune response are required. Nanova Read More

Background: Functional foods offer an appealing way to improve health and prevent chronic diseases, and this subject has received much attention lately. They are effective in preventing chronic diseases like cancer, diabetes, heart disease, and obesity, according to research. Objective: This work presents an in-depth analysis of functional foods, covering key challenges from a scientific, legal, and commercial perspective. Met Read More

Objective: The objective of this review is to present a succinct summary of the latest advancements in the utilization of hydrogels for diverse biomedical applications, with a particular focus on their revolutionary impact in augmenting the delivery of drugs, tissue engineering, along with diagnostic methodologies. Methods: Using a meticulous examination of current literary works, this review systematically scrutinizes the Read More

Aim: The current study aimed to develop an economic plant-based therapeutic agent to improve the treatment strategies for diseases at the nano-scale. Methods: In the current research, silver nanoparticles were synthesized using Trillium govanianum aqueous extract. Characterizations were done using UV–visible spectrophotometer, X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy. Read More

Background: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. N-acetylcysteine (NAC) is well known for its antioxidant properties, along with potential protective effects on COPD. However, the molecular mechanism of NAC against the apoptosis of alveolar epithelial cells (AECs) in COPD remains unclear. Objective: This study aimed to explore the anti-apoptosis effect of NAC in COPD Read More

Background: The rise of antibiotic-resistant bacteria necessitates the discovery of new, safe, and bioactive antimicrobial compounds. The antibacterial and antibiofilm activity of microalgae makes them a potential candidate for developing natural antibiotics to limit microbial infection in various fields. Objective: This study aimed to analyze the antibacterial effect of the methanolic extract of Schizochytrium sp. S31 microal Read More