Current Pharmaceutical Biotechnology - Volume 23, Issue 11, 2022

Liquid or injectable platelet-rich fibrin (PRF) is a second-generation platelet concentrate that is completely autologous and free of external additives, like bovine thrombin and calcium chloride. Additionally, it is the only one to be obtained in a liquid form among the second-generation platelet concentrates. This allows for wide applications such as maximizing injections or mixing with biomaterials such as bone grafts or Read More

Saffron is one of the most expensive spices in the world, and its popularity as a tasty food additive is spreading rapidly through many cultures and cuisines. Minerals and heavy metals are minor components found in saffron, which play a key role in the identification of the geographical origin, quality control, and food traceability, while they also affect human health. The chemical elements in saffron are measured using various Read More

Cardiovascular diseases, like coronary heart disease or artery disorders (arteriosclerosis, including artery solidification), heart failure (myocardial infarction), arrhythmias, congestive heart condition, stroke, elevated vital signs (hypertension), rheumatic heart disorder, and other circulatory system dysfunctions are the most common causes of death worldwide. Cardiovascular disorders are treated with stenting, coronary byp Read More

Background: The plant, Cannabis sativa, is heavily explored and researched with many industrial and pharmaceutical applications. The medicinal and therapeutic role of Cannabis sativa has been summarized in the paper, citing its mechanism of action and influence on the human body. Diseases like metabolic disorders, infectious diseases, and psychological disorders pose negative and long-term drastic effects on the bo Read More

Female reproductive tract cancers like ovarian, cervical, vaginal, etc. have led to a serious concern for reproductive health as well as an increase in physical and psychological stresses amongst women. Various conventional techniques like surgery, radiation and chemotherapy are employed but possess limitations such as organ toxicity, infection, nausea, vomiting, etc. Also, several nanotechnology-based synthetic vehicle delivery Read More

Objectives: The Plasmodium parasite is transmitted directly to humans through the Anopheles mosquito bite and causes vector-borne malaria, leading to the transmission of the disease in Southeast Asia, including India. The problem of persistent toxicity, along with the growing incidence of insect resistance, has led to the use of green pesticides to control the spread of the disease in a cost-effective and environment-friendly Read More

Background: Shortage of oxygen is a common condition for residents of high-altitude (HA) areas. In mammals, hemoglobin (Hb) has four derivatives: oxyhemoglobin (Hb-O2), carboxyhemoglobin (Hb-CO), sulfhemoglobin (Hb-S), and methemoglobin (Met-Hb). In HA areas, aberrant physiological performance of blood hemoglobin is well-established. Objectives: The study aimed to investigate the influence of 30 days o Read More

Background: Leonotis nepetifolia (L.) R. Br. (Lamiaceae) is a shrub traditionally used to alleviate inflammatory conditions. Objectives: The present study aimed at investigating the biological activity of methanolic nontransformed and transformed Rhizobium rhizogenes root extracts from L. nepetifolia against human melanoma cells. Methods: Cytotoxicity and genotoxicity properties, the impact on topoisomerase I activity, an Read More

Background: Autoimmune thyroiditis (AIT), a T cell-mediated organ-specific disorder, and transcription factors have a critical role in the regulation of immune responses, especially in the fate of T-helper cells. Objectives: This study aims to investigate changes in the gene expression profile of transcription factors and regulators in patients with different forms of thyroid pathology. Methods: We used the pathway-specific real-tim Read More

Background: Our study seeks to obtain data to assess the impact of circPUM1 on pancreatic cancer (PC) and its mechanism. Methods: The expression of circPUM1 and miR-200c-3p in PC and normal tissues and PC cell lines was collected and detected, and subsequently dual-luciferase assay-based verification of the binding site of the two was carried out. After interfering with circPUM1 expression in MIAPaCa-2 and PAN Read More