Current Pharmaceutical Biotechnology - Volume 20, Issue 13, 2019

Nowadays, distribution and microorganism resistance against antimicrobial compounds have caused crucial food safety problems. Hence, nanotechnology and zeolite are recognized as new approaches to manage this problem due to their inherent antimicrobial activity. Different studies have confirmed antimicrobial effects of Nano particles (NPs) (metal and metal oxide) and zeolite, by using various techniques to determi Read More

Chemotherapeutic agents have been used extensively in breast cancer remedy. However, most anticancer drugs cannot differentiate between cancer cells and normal cells, leading to toxic side effects. Also, the resulted drug resistance during chemotherapy reduces treatment efficacy. The development of targeted drug delivery offers great promise in breast cancer treatment both in clinical applications and in pharmaceutic Read More

The epidemiological impact of viral diseases, combined with the emergence and reemergence of some viruses, and the difficulties in identifying effective therapies, have encouraged several studies to develop new therapeutic strategies for viral infections. In this context, the use of immunotherapy for the treatment of viral diseases is increasing. One of the strategies of immunotherapy is the use of antibodies, partic Read More

Background: Periodontal disease is the most common oral condition that affects the tissue surrounding the teeth. The oral cavity is colonized by an impressive array of micro-organisms, many of which can colonize the implants such as Guided Tissue Regeneration (GTR) often utilized in recovering procedures that result in inflammation interfering with the bone regeneration. Methods: In the current study, a nano-hybrid Read More

Background: The vernacular name 'Harmal' is used for two plant species in Saudi Arabia, i.e. Peganum harmala L. and Rhazya stricta Decne. Both are important medicinal plants which offer interesting pharmacological properties. Objective: This study aimed to evaluate the genetic diversity among different populations of harmal based on chemical variations of alkaloids and molecular polymorphism. Methods: Total alkaloids Read More

Objective: MicroRNA (miR)-340-5p has been identified to play a key role in several cancers. However, the function of miR-340-5p in skin fibroblasts remains largely unknown. Methods: Gain of function experiments were performed by infecting normal skin fibroblast cells with a lentivirus carrying 22-bp miR-340-5p. Cell proliferation was detected by Cell Counting Kit-8 (CCK-8) assay. To uncover the mechanisms, mRNA-seq was used Read More