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Volume 26, Issue 4
  • ISSN: 1389-2010
  • E-ISSN: 1873-4316

Abstract

Background

In the current study, a comparative phytochemical analysis was carried out to explore the phenolic and flavonoid contents in the aerial parts of L and Retz growing in cultivated, reclaimed, and desert habitats.

Methods

High-performance liquid chromatography (HPLC) was used to detect Vicia methanolic extracts' individual phenolic and flavonoid constituents. The first-time synthesis of cadmium oxide nanoparticles (CdO NPs) using the aqueous extract of has been developed using a green approach. Also, the cytotoxicity of extract and CdO NPs was examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for unveiling them as anti-HAV and anti-AdV.

Results

Our results indicated that in the case of desert habitat, the contents of total phenolics (76.37 mg/g) and total flavonoids (65.23 mg/g) of were higher than those of (67.35 mg/g and 47.34 mg/g, respectively) and the contents of these secondary metabolites were even increased in collected from reclaimed land (phenolics: 119.77 mg/g, flavonoids: 88.61 mg/g). Also, surpassed in the contents of some individual HPLC constituents, and hence, was used to synthesize the green CdO NPs and subsequent antiviral tests. The average size of CdO NPs was determined to be 24.28 nm, and the transmission electron microscopy (TEM) images of CdO NPs clearly showed their spherical form and varying particle sizes, with different diameters in the range of 19–29 nm. MTT assay was positive to the exposure of CdO NPs in the normal cell line, proposing that CdO NPs can reduce cell viability. extract showed promising antiviral activity against Hepatitis A virus (HAV) and Adenovirus (AdV) with SI of 16.40 and 10.54. On the other hand, CdO NPs had poor antiviral activity against HAV with an SI of 4.74 and moderate antiviral activity against AdV with an SI of 10.54.

Conclusion

is now considered a new, valuable natural resource for phenolics and flavonoids, especially when grown in reclaimed soil. The green CdO NPs based on extract showed a promising antiviral effect against HAV and AdV.

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Bioactive Compounds from Vicia sativa L. and Vicia monantha Retz. with Unveiling Antiviral Potentials in Newly Green Synthesized CdO Nanoparticles
Current Pharmaceutical Biotechnology 26, 497 (2025); https://doi.org/10.2174/0113892010305452240427044346
/content/journals/cpb/10.2174/0113892010305452240427044346
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  • Article Type:     Research Article
Keyword(s): AdV; antiviral activity; Cd ONPs; flavonoids; HAV; HPLC; phenolic compounds; Vicia monantha; Vicia sativa

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