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Volume 26, Issue 4
  • ISSN: 1389-2010
  • E-ISSN: 1873-4316

Abstract

Background and Aims

Chlorpyrifos (CPF), which is classified as an Organophosphorus Pesticide (OP), has been identified as a toxic agent for the reproductive system due to its capacity to induce oxidative stress and inflammation. Curcumin (CUR) has been reported as a natural antioxidant and anti-inflammatory agent that could combat toxicity in various tissues. This study aims to examine the protective effects of CUR and its nanoformulation against reproductive impairment induced by CPF.

Methods

Forty-eight female Wistar albino rats were randomly allocated to six groups (n=8): control (0.5 mL of corn oil, the solvent for CPF), CPF (10 mg/kg), CPF + CUR 100 mg/kg/day, CPF + CUR 300 mg/kg/day, CPF + nano-micelle curcumin (NMC) 2.5 mg/kg/day, and CPF + NMC 5 mg/kg/day. The experimental treatment was performed for 30 days. Then, brain, ovary and uterus tissues were collected for measuring oxidative stress and inflammatory indices.

Results

MDA, NO, IL-6, and TNF-α concentrations significantly increased in the brain, ovary and uterus of the CPF group the control group (p < 0.001). The levels of GSH and SOD in the uterus, ovaries, and brain exhibited a significant decrease in the CPF group compared to the control group (p < 0.05). However, CUR (300 mg/kg) and NMC (5 mg/kg) significantly decreased MDA, NO, TNF-α, and Il-6 and increased SOD and GSH levels in the uterus, ovaries and brain of the CPF-exposed animals the CPF-exposed non-treated animals (p < 0.001).

Conclusion

Our findings indicated that CUR and NMC could be effective in alleviating CPF-induced reproductive toxicity.

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2025-03-29

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/content/journals/cpb/10.2174/0113892010297408240319073735
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Protective Effects of Curcumin and Nanomicelle Curcumin on Chlorpyrifos-induced Oxidative Damage and Inflammation in the Uterus, Ovary and Brain of Rats
Current Pharmaceutical Biotechnology 26, 490 (2025); https://doi.org/10.2174/0113892010297408240319073735
/content/journals/cpb/10.2174/0113892010297408240319073735
/content/journals/cpb/10.2174/0113892010297408240319073735
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  • Article Type:     Research Article
Keyword(s): Chlorpyrifos; curcumin; inflammation; nanomicelle curcumin; oxidative stress; reproductive system; wistar rat

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