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image of Monkeypox: A Comprehensive Analysis of Emerging Epidemiological Trends, Pathogenesis, and Advanced Therapeutic Interventions

Abstract

Monkeypox has become a major worldwide health issue, which has brought attention to the necessity of having a thorough understanding of this zoonotic virus. An extensive examination of the monkeypox virus's taxonomy, morphology, replication cycle, transmission, clinical symptoms, and treatment options is given in this article. The review also addresses the possibility that, given the growing interconnection of human populations and the drop in smallpox vaccination rates, the monkeypox virus will take over the ecological niche once occupied by the smallpox virus.

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2025-02-04
2025-04-25

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References

  1. Ladnyj I.D. Ziegler P. Kima E. A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo. Bull. World Health Organ. 1972 46 5 593 597 4340218
    [Google Scholar]
  2. Rahman M.T. Sobur M.A. Islam M.S. Ievy S. Hossain M.J. El Zowalaty M.E. Rahman A.M.M.T. Ashour H.M. Zoonotic diseases: Etiology, impact, and control. Microorganisms 2020 8 9 1405 10.3390/microorganisms8091405 32932606
    [Google Scholar]
  3. Essbauer S. Pfeffer M. Meyer H. Zoonotic poxviruses. Vet. Microbiol. 2010 140 3-4 229 236 10.1016/j.vetmic.2009.08.026 19828265
    [Google Scholar]
  4. Slingenbergh J. Gilbert M. BALOGH de K. Wint W. Ecological sources of zoonotic diseases. Rev. Sci. Tech. 2004 23 2 467 484 10.20506/rst.23.2.1492 15702714
    [Google Scholar]
  5. Martella V. Bányai K. Matthijnssens J. Buonavoglia C. Ciarlet M. Zoonotic aspects of rotaviruses. Vet. Microbiol. 2010 140 3-4 246 255 10.1016/j.vetmic.2009.08.028 19781872
    [Google Scholar]
  6. Ye Z.W. Yuan S. Yuen K.S. Fung S.Y. Chan C.P. Jin D.Y. Zoonotic origins of human coronaviruses. Int. J. Biol. Sci. 2020 16 10 1686 1697 10.7150/ijbs.45472 32226286
    [Google Scholar]
  7. Cai W. Ryan U. Xiao L. Feng Y. Zoonotic giardiasis: An update. Parasitol. Res. 2021 120 12 4199 4218 10.1007/s00436‑021‑07325‑2 34623485
    [Google Scholar]
  8. Suárez Rodríguez B. Guzmán Herrador B.R. Díaz Franco A. Sánchez-Seco Fariñas M.P. del Amo Valero J. Aginagalde Llorente A.H. de Agreda J.P.A.P. Malonda R.C. Castrillejo D. Chirlaque López M.D. Chong Chong E.J. Balbuena S.F. García V.G. García-Cenoz M. Hernández L.G. Montalbán E.G. Carril F.G. Cortijo T.G. Bueno S.J. Sánchez A.L. Linares Dópido J.A. Lorusso N. Martins M.M. Martínez Ochoa E.M. Mateo A.M. Peña J.M. Antón A.I.N. Otero Barrós M.T. Martinez M.C.P. Jiménez P.P. Martín O.G.P. Rivas Pérez A.I. García M.S. Response Group N.M. Soria F.S. Sierra Moros M.J. Epidemiologic features and control measures during monkeypox outbreak, Spain, June 2022. Emerg. Infect. Dis. 2022 28 9 1847 1851 10.3201/eid2809.221051 35820165
    [Google Scholar]
  9. Sah R. Padhi B.K. Siddiq A. Abdelaal A. Reda A. Ismail Lashin B. Mohanty A. Public health emergency of international concern declared by the World Health Organization for monkeypox. Glob. Secur. Health Sci. Policy 2022 7 1 51 56 10.1080/23779497.2022.2124185
    [Google Scholar]
  10. Ren S.Y. Li J. Gao R.D. 2022 Monkeypox outbreak: Why is it a public health emergency of international concern? What can we do to control it? World J. Clin. Cases 2022 10 30 10873 10881 10.12998/wjcc.v10.i30.10873 36338228
    [Google Scholar]
  11. Rahimi F. Darvishi M. Talebi Bezmin Abadi A. WHO declared monkeypox a public-health emergency of international concern: A case for prevention rationale. Int. J. Surg. 2022 105 106850 10.1016/j.ijsu.2022.106850 36028142
    [Google Scholar]
  12. Jeyaraman M. Selvaraj P. Halesh M.B. Jeyaraman N. Nallakumarasamy A. Gupta M. Maffulli N. Gupta A. Monkeypox: An emerging global public health emergency. Life 2022 12 10 1590 10.3390/life12101590 36295025
    [Google Scholar]
  13. Chopra H. Kaur A. Vaccination strategies for monkey pox: An update. Indo Glob. J. Pharm. Sci. 2022 12 245 247 10.35652/IGJPS.2022.12031
    [Google Scholar]
  14. Yamane I. Epidemics of emerging animal diseases and food-borne infection problems over the last 5 years in Japan. Ann. N. Y. Acad. Sci. 2006 1081 1 30 38 10.1196/annals.1373.003 17135492
    [Google Scholar]
  15. Reddy B.L. Saier M.H.J. Jr The causal relationship between eating animals and viral epidemics. Microb. Physiol. 2020 30 1-6 2 8 10.1159/000511192 32957108
    [Google Scholar]
  16. Gilchrist M.J. Greko C. Wallinga D.B. Beran G.W. Riley D.G. Thorne P.S. The potential role of concentrated animal feeding operations in infectious disease epidemics and antibiotic resistance. Environ. Health Perspect. 2007 115 2 313 316 10.1289/ehp.8837 17384785
    [Google Scholar]
  17. Alakunle E. Moens U. Nchinda G. Okeke M.I. Monkeypox virus in Nigeria: Infection biology, epidemiology, and evolution. Viruses 2020 12 11 1257 10.3390/v12111257 33167496
    [Google Scholar]
  18. Damon IK Manual of Clinical Microbiology. Wiley 2011
    [Google Scholar]
  19. Poxviridae D.G. Veterinary Microbiology. John Wiley & Sons 2022 522 532
    [Google Scholar]
  20. Oliveira G. Rodrigues R. Lima M. Drumond B. Abrahão J. Poxvirus host range genes and virus–host spectrum: A critical review. Viruses 2017 9 11 331 10.3390/v9110331 29112165
    [Google Scholar]
  21. Gjessing M.C. Yutin N. Tengs T. Senkevich T. Koonin E. Rønning H.P. Alarcon M. Ylving S. Lie K.I. Saure B. Tran L. Moss B. Dale O.B. Salmon gill poxvirus, the deepest representative of the Chordopoxvirinae. J. Virol. 2015 89 18 9348 9367 10.1128/JVI.01174‑15 26136578
    [Google Scholar]
  22. Borisevich S.V. Stovba L.F. Paveliev D.I. Poxvirus disease of squirrels (poxviridae, chordopoxvirinae, SQPV - squirrel poxvirus). Probl. Virol. 2018 63 2 53 57 10.18821/0507‑4088‑2018‑63‑2‑53‑57 36494921
    [Google Scholar]
  23. Shchelkunov SN Marennikova SS Moyer RW Marennikova SS Moyer RW Classification of Poxviruses and brief characterization of the genus Orthopoxvirus. Springer Boston, MA. 2005
    [Google Scholar]
  24. Barrett JW McFadden G Origin and evolution of poxviruses. Origin and Evolution of Viruses. Academic Press. 2008 431 446 10.1016/B978‑0‑12‑374153‑0.00019‑9
    [Google Scholar]
  25. Duignan PJ Van Bressem MF Cortéz-Hinojosa G Kennedy-Stoskopf S CRC Handbook of Marine Mammal Medicine. CRC Press. 2018 331 366
    [Google Scholar]
  26. Borisevich S.V. Marennikova S.S. Stovba L.F. Petrov A.A. Krotkov V.T. Makhlai A.A. Buffalopox. Probl. Virol. 2016 61 5 200 204 10.18821/0507‑4088‑2016‑61‑5‑200‑204 29323851
    [Google Scholar]
  27. Singh R.K. Hosamani M. Balamurugan V. Bhanuprakash V. Rasool T.J. Yadav M.P. Buffalopox: An emerging and re-emerging zoonosis. Anim. Health Res. Rev. 2007 8 1 105 114 10.1017/S1466252307001259 17692147
    [Google Scholar]
  28. Hutchinson D Kunasekaran M Emergence of novel orthopox virus in Alaska, USA. Glob. Biosecurity. 2022 4 1
    [Google Scholar]
  29. Burek K.A. Beckmen K. Gelatt T. Fraser W. Bracht A.J. Smolarek K.A. Romero C.H. Poxvirus infection of Steller sea lions (Eumetopias jubatus) in Alaska. J. Wildl. Dis. 2005 41 4 745 752 10.7589/0090‑3558‑41.4.745 16456163
    [Google Scholar]
  30. Tuomi P.A. Murray M.J. Garner M.M. Goertz C.E.C. Nordhausen R.W. Burek-Huntington K.A. Getzy D.M. Nielsen O. Archer L.L. Maness H.T.D. Wellehan J.F.X. Jr Waltzek T.B. Novel poxvirus infection in northern and southern sea otters (Enhydra lutris kenyoni and Enhydra lutris neiris), Alaska and California, USA. J. Wildl. Dis. 2014 50 3 607 615 10.7589/2013‑08‑217 24807180
    [Google Scholar]
  31. Kumar P. Chaudhary B. Yadav N. Devi S. Pareek A. Alla S. Kajal F. Nowrouzi-Kia B. Chattu V.K. Gupta M.M. Recent advances in research and management of human Monkeypox virus: An emerging global health threat. Viruses 2023 15 4 937 10.3390/v15040937 37112916
    [Google Scholar]
  32. Tsai Y.T. Chang S.Y. Lee C.N. Kao C.L. Human TLR3 recognizes dengue virus and modulates viral replication in vitro. Cell. Microbiol. 2009 11 4 604 615 10.1111/j.1462‑5822.2008.01277.x 19134117
    [Google Scholar]
  33. Delaney W.E. IV Yang H. Westland C.E. Das K. Arnold E. Gibbs C.S. Miller M.D. Xiong S. The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro. J. Virol. 2003 77 21 11833 11841 10.1128/JVI.77.21.11833‑11841.2003 14557667
    [Google Scholar]
  34. Stewart C.E. Randall R.E. Adamson C.S. Inhibitors of the interferon response enhance virus replication in vitro. PLoS One 2014 9 11 e112014 10.1371/journal.pone.0112014 25390891
    [Google Scholar]
  35. Hatta M. Kawaoka Y. The NB protein of influenza B virus is not necessary for virus replication in vitro. J. Virol. 2003 77 10 6050 6054 10.1128/JVI.77.10.6050‑6054.2003 12719596
    [Google Scholar]
  36. Teng M.N. Whitehead S.S. Collins P.L. Contribution of the respiratory syncytial virus G glycoprotein and its secreted and membrane-bound forms to virus replication in vitro and in vivo. Virology 2001 289 2 283 296 10.1006/viro.2001.1138 11689051
    [Google Scholar]
  37. Fernández de Marco M.M. Alejo A. Hudson P. Damon I.K. Alcami A. The highly virulent variola and monkeypox viruses express secreted inhibitors of type I interferon. FASEB J. 2010 24 5 1479 1488 10.1096/fj.09‑144733 20019241
    [Google Scholar]
  38. Houldcroft C.J. Beale M.A. Breuer J. Clinical and biological insights from viral genome sequencing. Nat. Rev. Microbiol. 2017 15 3 183 192 10.1038/nrmicro.2016.182 28090077
    [Google Scholar]
  39. Structure and organization of the viral genome Hodder Arnold London, United Kingdom 2005 73 94
    [Google Scholar]
  40. Roux S. Adriaenssens E.M. Dutilh B.E. Koonin E.V. Kropinski A.M. Krupovic M. Kuhn J.H. Lavigne R. Brister J.R. Varsani A. Amid C. Aziz R.K. Bordenstein S.R. Bork P. Breitbart M. Cochrane G.R. Daly R.A. Desnues C. Duhaime M.B. Emerson J.B. Enault F. Fuhrman J.A. Hingamp P. Hugenholtz P. Hurwitz B.L. Ivanova N.N. Labonté J.M. Lee K.B. Malmstrom R.R. Martinez-Garcia M. Mizrachi I.K. Ogata H. Páez-Espino D. Petit M.A. Putonti C. Rattei T. Reyes A. Rodriguez-Valera F. Rosario K. Schriml L. Schulz F. Steward G.F. Sullivan M.B. Sunagawa S. Suttle C.A. Temperton B. Tringe S.G. Thurber R.V. Webster N.S. Whiteson K.L. Wilhelm S.W. Wommack K.E. Woyke T. Wrighton K.C. Yilmaz P. Yoshida T. Young M.J. Yutin N. Allen L.Z. Kyrpides N.C. Eloe-Fadrosh E.A. Minimum information about an uncultivated virus genome (MIUViG). Nat. Biotechnol. 2019 37 1 29 37 10.1038/nbt.4306 30556814
    [Google Scholar]
  41. Bernard H.U. Regulatory elements in the viral genome. Virology 2013 445 1-2 197 204 10.1016/j.virol.2013.04.035 23725692
    [Google Scholar]
  42. Büttner M. Rziha H.J. Parapoxviruses: From the lesion to the viral genome. J. Vet. Med. B Infect. Dis. Vet. Public Health 2002 49 1 7 16 10.1046/j.1439‑0450.2002.00539.x 11911596
    [Google Scholar]
  43. Brister J.R. Ako-adjei D. Bao Y. Blinkova O. NCBI viral genomes resource. Nucleic Acids Res. 2015 43 D1 D571 D577 10.1093/nar/gku1207 25428358
    [Google Scholar]
  44. Catalano C.E. Catalano C.E. Viral genome packaging machines: An overview. Springer US 2005 10.1007/0‑387‑28521‑0_1
    [Google Scholar]
  45. Jiang X. Graham D.Y. Wang K. Estes M.K. Norwalk virus genome cloning and characterization. Science 1990 250 4987 1580 1583 10.1126/science.2177224 2177224
    [Google Scholar]
  46. Beer E.M. Rao V.B. A systematic review of the epidemiology of human monkeypox outbreaks and implications for outbreak strategy. PLoS Negl. Trop. Dis. 2019 13 10 e0007791 10.1371/journal.pntd.0007791 31618206
    [Google Scholar]
  47. Reed K.D. Melski J.W. Graham M.B. Regnery R.L. Sotir M.J. Wegner M.V. Kazmierczak J.J. Stratman E.J. Li Y. Fairley J.A. Swain G.R. Olson V.A. Sargent E.K. Kehl S.C. Frace M.A. Kline R. Foldy S.L. Davis J.P. Damon I.K. The detection of monkeypox in humans in the Western Hemisphere. N. Engl. J. Med. 2004 350 4 342 350 10.1056/NEJMoa032299 14736926
    [Google Scholar]
  48. Aljabali A.A.A. Obeid M.A. Nusair M.B. Hmedat A. Tambuwala M.M. Monkeypox virus: An emerging epidemic. Microb. Pathog. 2022 173 Pt A 105794 10.1016/j.micpath.2022.105794 36179973
    [Google Scholar]
  49. Letafati A. Sakhavarz T. Monkeypox virus: A review. Microb. Pathog. 2023 176 106027 10.1016/j.micpath.2023.106027 36758824
    [Google Scholar]
  50. Li H. Zhang H. Ding K. Wang X.H. Sun G.Y. Liu Z.X. Luo Y. The evolving epidemiology of monkeypox virus. Cytokine Growth Factor Rev. 2022 68 1 12 10.1016/j.cytogfr.2022.10.002 36244878
    [Google Scholar]
  51. Hobson G. Adamson J. Adler H. Firth R. Gould S. Houlihan C. Johnson C. Porter D. Rampling T. Ratcliffe L. Russell K. Shankar A.G. Wingfield T. Family cluster of three cases of monkeypox imported from Nigeria to the United Kingdom, May 2021. Euro Surveill. 2021 26 32 2100745 10.2807/1560‑7917.ES.2021.26.32.2100745 34387184
    [Google Scholar]
  52. Shchelkunov SN Marennikova SS Moyer RW Marennikova SS Moyer RW Classification of Poxviruses and brief characterization of the genus Orthopoxvirus. Springer Boston, MA 2005
    [Google Scholar]
  53. Damon IK Manual of clinical microbiology ASM Press 2011 1647 1658
    [Google Scholar]
  54. Emerson G.L. Li Y. Frace M.A. Olsen-Rasmussen M.A. Khristova M.L. Govil D. Sammons S.A. Regnery R.L. Karem K.L. Damon I.K. Carroll D.S. The phylogenetics and ecology of the orthopoxviruses endemic to North America. PLoS One 2009 4 10 e7666 10.1371/journal.pone.0007666 19865479
    [Google Scholar]
  55. Hardin C.C. Monkeypox. N. Engl. J. Med. 2022 387 1783 1793
    [Google Scholar]
  56. Duraffour S. Meyer H. Andrei G. Snoeck R. Camelpox virus. Antiviral Res. 2011 92 2 167 186 10.1016/j.antiviral.2011.09.003 21945248
    [Google Scholar]
  57. Afonso C.L. Tulman E.R. Lu Z. Zsak L. Sandybaev N.T. Kerembekova U.Z. Zaitsev V.L. Kutish G.F. Rock D.L. The genome of camelpox virus. Virology 2002 295 1 1 9 10.1006/viro.2001.1343 12033760
    [Google Scholar]
  58. Balamurugan V. Venkatesan G. Bhanuprakash V. Singh R.K. Camelpox, an emerging orthopox viral disease. Indian J. Virol. 2013 24 3 295 305 10.1007/s13337‑013‑0145‑0 24426291
    [Google Scholar]
  59. Cardeti G. Gruber C.E.M. Eleni C. Carletti F. Castilletti C. Manna G. Rosone F. Giombini E. Selleri M. Lapa D. Puro V. Di Caro A. Lorenzetti R. Scicluna M.T. Grifoni G. Rizzoli A. Tagliapietra V. De Marco L. Capobianchi M.R. Autorino G.L. Fatal outbreak in Tonkean macaques caused by possibly novel orthopoxvirus, Italy, January 2015. Emerg. Infect. Dis. 2017 23 12 1941 1949 10.3201/eid2312.162098 28975882
    [Google Scholar]
  60. Belongia E.A. Naleway A.L. Smallpox vaccine: The good, the bad, and the ugly. Clin. Med. Res. 2003 1 2 87 92 10.3121/cmr.1.2.87 15931293
    [Google Scholar]
  61. Shchelkunov S.N. Emergence and reemergence of smallpox: The need for development of a new generation smallpox vaccine. Vaccine 2011 29 Suppl. 4 D49 D53 10.1016/j.vaccine.2011.05.037 22185833
    [Google Scholar]
  62. Parrino J. Graham B. Smallpox vaccines: Past, present, and future. J. Allergy Clin. Immunol. 2006 118 6 1320 1326 10.1016/j.jaci.2006.09.037 17157663
    [Google Scholar]
  63. Frey S.E. Couch R.B. Tacket C.O. Treanor J.J. Wolff M. Newman F.K. Atmar R.L. Edelman R. Nolan C.M. Belshe R.B. Clinical responses to undiluted and diluted smallpox vaccine. N. Engl. J. Med. 2002 346 17 1265 1274 10.1056/NEJMoa020534 11923490
    [Google Scholar]
  64. Vollmar J. Arndtz N. Eckl K.M. Thomsen T. Petzold B. Mateo L. Schlereth B. Handley A. King L. Hülsemann V. Tzatzaris M. Merkl K. Wulff N. Chaplin P. Safety and immunogenicity of IMVAMUNE, a promising candidate as a third generation smallpox vaccine. Vaccine 2006 24 12 2065 2070 10.1016/j.vaccine.2005.11.022 16337719
    [Google Scholar]
  65. Rimoin A.W. Mulembakani P.M. Johnston S.C. Lloyd Smith J.O. Kisalu N.K. Kinkela T.L. Blumberg S. Thomassen H.A. Pike B.L. Fair J.N. Wolfe N.D. Shongo R.L. Graham B.S. Formenty P. Okitolonda E. Hensley L.E. Meyer H. Wright L.L. Muyembe J.J. Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc. Natl. Acad. Sci. USA 2010 107 37 16262 16267 10.1073/pnas.1005769107 20805472
    [Google Scholar]
  66. Rota P.A. Wallis T.R. Harmon M.W. Rota J.S. Kendal A.P. Nerome K. Cocirculation of two distinct evolutionary lineages of influenza type B virus since 1983. Virology 1990 175 1 59 68 10.1016/0042‑6822(90)90186‑U 2309452
    [Google Scholar]
  67. Holmes E.C. What does virus evolution tell us about virus origins? J. Virol. 2011 85 11 5247 5251 10.1128/JVI.02203‑10 21450811
    [Google Scholar]
  68. Chen N. Li G. Liszewski M.K. Atkinson J.P. Jahrling P.B. Feng Z. Schriewer J. Buck C. Wang C. Lefkowitz E.J. Esposito J.J. Harms T. Damon I.K. Roper R.L. Upton C. Buller R.M.L. Virulence differences between monkeypox virus isolates from West Africa and the Congo basin. Virology 2005 340 1 46 63 10.1016/j.virol.2005.05.030 16023693
    [Google Scholar]
  69. Happi C. Adetifa I. Mbala P. Njouom R. Nakoune E. Happi A. Ndodo N. Ayansola O. Mboowa G. Bedford T. Neher R.A. Roemer C. Hodcroft E. Tegally H. O’Toole Á. Rambaut A. Pybus O. Kraemer M.U.G. Wilkinson E. Isidro J. Borges V. Pinto M. Gomes J.P. Freitas L. Resende P.C. Lee R.T.C. Maurer-Stroh S. Baxter C. Lessells R. Ogwell A.E. Kebede Y. Tessema S.K. de Oliveira T. Urgent need for a non-discriminatory and non-stigmatizing nomenclature for monkeypox virus. PLoS Biol. 2022 20 8 e3001769 10.1371/journal.pbio.3001769 35998195
    [Google Scholar]
  70. Akter F. Hasan T.B. Alam F. Das A. Afrin S. Maisha S. Masud A.A. Km S.U.R. Effect of prior immunisation with smallpox vaccine for protection against human Mpox: A systematic review. Rev. Med. Virol. 2023 33 4 e2444 10.1002/rmv.2444 36999223
    [Google Scholar]
  71. Dick G. Routine smallpox vaccination. BMJ 1971 3 5767 163 166 10.1136/bmj.3.5767.163 5557869
    [Google Scholar]
  72. Mercer A.J. Smallpox and epidemiological-demographic change in Europe: The role of vaccination. Popul. Stud. (Camb.) 1985 39 2 287 307 10.1080/0032472031000141496 11620665
    [Google Scholar]
  73. Multi-country monkeypox outbreak in non-endemic countries. 2022 Available from: https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON385
  74. Assessment RR Monkeypox multi-country outbreak. Eur. Cent. Dis. Prev. Control 2022
    [Google Scholar]
  75. Vaughan A. Aarons E. Astbury J. Brooks T. Chand M. Flegg P. Hardman A. Harper N. Jarvis R. Mawdsley S. McGivern M. Morgan D. Morris G. Nixon G. O’Connor C. Palmer R. Phin N. Price D.A. Russell K. Said B. Schmid M.L. Vivancos R. Walsh A. Welfare W. Wilburn J. Dunning J. Human-to-human transmission of monkeypox virus, United Kingdom, October 2018. Emerg. Infect. Dis. 2020 26 4 782 785 10.3201/eid2604.191164 32023204
    [Google Scholar]
  76. Second meeting of the International Health Regulations (2005) Emergency Committee regarding the upsurge of mpox 2024. 2005 Available from: https://www.who.int/news/item/28-11-2024-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-upsurge-of-mpox-2024
    [Google Scholar]
  77. Kerala reports India’s first confirmed monkeypox case. 2022 Available from: https://www.thehindu.com/sci-tech/health/kerala-reports-indias-first-confirmed-monkeypox-case/article65640571.ece
  78. India confirms first case of monkeypox in WHO South-East Asia Region. 2022 Available from: https://www.who.int/southeastasia/news/detail/15-07-2022-india-confirms-first-case-of-monkeypox-in-who-south-east-asia-region
  79. India’s first Mpox Clad-1 case in Kerala: Symptoms, causes of strain that sparked WHO public health emergency alert. 2022 Available from: https://www.livemint.com/news/indias-first-mpox-clad-1-case-in-kerala-symptoms-causes-of-strain-that-sparked-who-public-health-emergency-alert-11727097419110.html
  80. Andrews M.A. Areekal B. Rajesh K.R. Krishnan J. Suryakala R. Krishnan B. Muraly C.P. Santhosh P.V. First confirmed case of COVID-19 infection in India: A case report. Indian J. Med. Res. 2020 151 5 490 492 10.4103/ijmr.IJMR_2131_20 32611918
    [Google Scholar]
  81. Dsouza D.D. Quadros S. Hyderabadwala Z.J. Mamun M.A. Aggregated COVID-19 suicide incidences in India: Fear of COVID-19 infection is the prominent causative factor. Psychiatry Res. 2020 290 113145 10.1016/j.psychres.2020.113145 32544650
    [Google Scholar]
  82. Bhadra A. Mukherjee A. Sarkar K. Impact of population density on Covid-19 infected and mortality rate in India. Model. Earth Syst. Environ. 2021 7 1 623 629 10.1007/s40808‑020‑00984‑7 33072850
    [Google Scholar]
  83. Kaushik S. Kaushik S. Sharma Y. Kumar R. Yadav J.P. The Indian perspective of COVID-19 outbreak. Virusdisease 2020 31 2 146 153 10.1007/s13337‑020‑00587‑x 32368570
    [Google Scholar]
  84. Ghosh A. Nundy S. Mallick T.K. How India is dealing with COVID-19 pandemic. Sens. Int. 2020 1 100021 10.1016/j.sintl.2020.100021 34766039
    [Google Scholar]
  85. Hraib M. Jouni S. Albitar M.M. Alaidi S. Alshehabi Z. The outbreak of monkeypox 2022: An overview. Ann. Med. Surg. 2022 79 104069 10.1016/j.amsu.2022.104069 35860140
    [Google Scholar]
  86. Deshwal V. Kumar V. Study of coronavirus disease (COVID-19) outbreak in India. Open Nurs. J. 2021 15 1 62 73 10.2174/1874434602115010062
    [Google Scholar]
  87. Lorsch J.R. Smallpox antivirals effective against monkeypox. 2022 Available from: https://cen.acs.org/pharmaceuticals/rare-disease/smallpox-antivirals-effective-against-monkeypox/100/i19
  88. Prévost J. Sloan A. Deschambault Y. Tailor N. Tierney K. Azaransky K. Kammanadiminti S. Barker D. Kodihalli S. Safronetz D. Treatment efficacy of cidofovir and brincidofovir against clade II Monkeypox virus isolates. Antiviral Res. 2024 231 105995 10.1016/j.antiviral.2024.105995 39243894
    [Google Scholar]
  89. Wang X. Lun W. Skin manifestation of human monkeypox. J. Clin. Med. 2023 12 3 914 10.3390/jcm12030914 36769562
    [Google Scholar]
  90. Kabuga A.I. El Zowalaty M.E. A review of the monkeypox virus and a recent outbreak of skin rash disease in Nigeria. J. Med. Virol. 2019 91 4 533 540 10.1002/jmv.25348 30357851
    [Google Scholar]
  91. Altindis M. Puca E. Shapo L. Diagnosis of monkeypox virus – An overview. Travel Med. Infect. Dis. 2022 50 102459 10.1016/j.tmaid.2022.102459 36109000
    [Google Scholar]
  92. Aldhaeefi M. Rungkitwattanakul D. Unonu J. Franklin C.J. Lyons J. Hager K. Daftary M.N. The 2022 human monkeypox outbreak: Clinical review and management guidance. Am. J. Health Syst. Pharm. 2023 80 2 44 52 10.1093/ajhp/zxac300 36259674
    [Google Scholar]
  93. Heskin J. Belfield A. Milne C. Brown N. Walters Y. Scott C. Bracchi M. Moore L.S.P. Mughal N. Rampling T. Winston A. Nelson M. Duncan S. Jones R. Price D.A. Mora-Peris B. Transmission of monkeypox virus through sexual contact – A novel route of infection. J. Infect. 2022 85 3 334 363 10.1016/j.jinf.2022.05.028 35659548
    [Google Scholar]
  94. Singhal T. Kabra S.K. Lodha R. Monkeypox: A review. Indian J. Pediatr. 2022 89 10 955 960 10.1007/s12098‑022‑04348‑0 35947269
    [Google Scholar]
  95. Smith L.E. Potts H.W. Brainard J. May T. Oliver I. Amlôt R. Yardley L. Rubin G.J. Mpox knowledge, attitudes, beliefs, and intended behaviour in the general population and men who are gay, bisexual, and who have sex with men. medRxiv 2022 10.1101/2022.12.07.22283201
    [Google Scholar]
  96. Patrocinio-Jesus R. Peruzzu F. Monkeypox genital lesions. N. Engl. J. Med. 2022 387 1 66 10.1056/NEJMicm2206893 35704421
    [Google Scholar]
  97. Mpox (monkeypox) - Symptoms, causes, treatment and prevention Available from: https://www.pacehospital.com/monkeypox-mpox-symptoms-causes-treatment-and-preventions
  98. Episode #76 - Monkeypox: Who is at risk? 2024 Available from: https://ncdc.mohfw.gov.in/wp-content/uploads/2024/08/CD-Alert-Mpox-August-2024.pdf
/content/journals/covid/10.2174/0126667975364848250122083007
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Monkeypox: A Comprehensive Analysis of Emerging Epidemiological Trends, Pathogenesis, and Advanced Therapeutic Interventions
Bentham Science Publishers ; https://doi.org/10.2174/0126667975364848250122083007
/content/journals/covid/10.2174/0126667975364848250122083007
/content/journals/covid/10.2174/0126667975364848250122083007
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  • Article Type:     Review Article
Keywords: prevention ; zoonosis ; orthopoxvirus ; Monkeypox ; pathogenesis ; treatment ; transmission

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