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2000
Volume 21, Issue 7
  • ISSN: 1570-1794
  • E-ISSN: 1875-6271

Abstract

Aims: In order to study on structure-activity relationships of benzofurans. Background: Benzofuran is a kind of natural compound widely existing in nature with pharmacological effects. The development of new anticancer benzofuran derivatives has attracted more and more attention. Methods: We have introduced an active quinazoline unit into piperazine-substituted benzofuran, prepared a series of quinazoline-benzofuran compounds, and evaluated cytotoxic activity against a panel of human tumor cell lines by MTT assay. Results: 48 novel quinazoline-substituted benzofuran derivatives have been prepared, and , cytotoxic activity against five human tumor cell lines was evaluated. The results indicated that some quinazoline-benzofuran conjugates showed selective inhibitory activity against tumor cell lines. Conclusion: We have found that compound 14x displayed excellent cytotoxic activity, which could be considered a potential anticancer agent.

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/content/journals/cos/10.2174/1570179420666230623113535
2024-11-01
2025-07-08
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  • Article Type:
    Research Article
Keyword(s): anticancer; benzofuran; conjugates; cytotoxic activity; Quinazoline; synthesis
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