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2000
Volume 21, Issue 2
  • ISSN: 1570-1794
  • E-ISSN: 1875-6271

Abstract

Julia-Lythgoe olefination (or simply Julia olefination) is an olefination process between phenyl sulfones and aldehydes (or ketones) to give alkenes after alcohol functionalization and reductive elimination using sodium amalgam or SmI2. It is mainly used to synthesize E-alkenes and is a key step in numerous total syntheses of many natural products. This review exclusively deals with the Julia-Lythgoe olefination and concentrates mainly on the applications of this reaction in natural product synthesis covering literature up to 2021.

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2024-03-01
2025-07-26

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  • Article Type:     Review Article
Keyword(s): aldehyde; alkenes; Julia-lythgoe olefination; olefin synthesis; sulfones; total synthesis

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