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Introduction: Intercapillary research in mathematics and other pure sciences areas has always helped humanity quantify natural phenomena. Materials & Method: This article also contributes to which valency-based topological indices are implemented on tetrahedral sheets of clay minerals. These indices have been used for a long time and are considered the most powerful tools to quantify chemical graphs. Results: The atoms in the chemical compound and the bonds between the atoms are depicted as the graph’s vertices and edges, respectively. Conclusion: The valency (or degree) of a vertex in a graph is the number of edges incident to that vertex. In this article, various degree-based indices and their modifications are determined to check each types’ significance.