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2000
Volume 18, Issue 7
  • ISSN: 1570-1794
  • E-ISSN: 1875-6271

Abstract

β-Amino-α,β-enones or β-enamino carbonyl compounds are versatile synthons intermediates for the construction of various bio-active heterocyclic compounds and have been established as multipurpose synthetic precursors in organic syntheses and in pharmaceutical developments. In this work, we will discuss the different synthetic routes to obtain β−amino−α,β-enones or β-enamino carbonyl compounds, their reactions, and their utility in the construction of organic frameworks and heterocyclic ring systems. Structurally, β- amino-α,β-enones are attractive intermediates that syndicate the ambident behaviours of nucleophilicity and electrophilicity of enones at the same time. β-amino-α,β-enones have been known as acceptors in both 1,2- and 1,4- additions that make them good intermediate compounds for annulation to different heterocycles.

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/content/journals/cos/10.2174/1570179418666210512015725
2021-11-01
2025-07-11
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  • Article Type:
    Review Article
Keyword(s): Enaminones; heterocycles; nitrogen nucleophiles; synthesis; β-amino-α; β-enamino; β-enones
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