Solvent-mediated Highly Efficient Synthesis of [1,2,4]Triazolo/benzimidazoloquinazolinone Derivatives

Objective: An efficient and catalyst-free procedure for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones has been developed in 2,2,2-trifluoroethanol or deep eutectic solvent(DESs) as a clean reaction media. Methods: All of the obtained products are known compounds and identified by IR, 1HNMR,13CNMR, and melting points. Result: Various products were obtained in good to excellent yields under reaction conditions. Conclusion: We have efficiently developed a practical and catalyst-free approach for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones employing TFE as a clean and reusable media.