Skip to content
2000
Volume 16, Issue 6
  • ISSN: 1570-1794
  • E-ISSN: 1875-6271

Abstract

Multicomponent reactions (MCRs) are composed of three or more reagents in which the final product has all or most of the carbon atoms from its starting materials. These reactions represent, in the medicinal chemistry context, great potential in the research for new bioactive compounds, since their products can present great structural complexity. The aim of this review is to present the main multicomponent reactions since the original report by Strecker in 1850 from nowadays, covering their evolution, highlighting their significance in the discovery of new bioactive compounds. The use of MCRs is, indeed, a growing field of interest in the synthesis of bioactive compounds and approved drugs, with several examples of commerciallyavailable drugs that are (or can be) obtained through these protocols.

Loading

Article metrics loading...

/content/journals/cos/10.2174/1570179416666190718153703
2019-09-01
2025-05-28
Loading full text...

Full text loading...

/content/journals/cos/10.2174/1570179416666190718153703
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test