Multicomponent Synthesis of Novel bis(2-amino-tetrahydro-4H-chromene-3- carbonitrile) Derivatives Linked to Arene or Heteroarene Cores

An efficient and convenient route for synthesis of novel bis 4H-chromene-3- carbonitrile derivatives is reported. The synthetic pathway involves one pot, multi-component reaction of bis-aldehydes, malononitrile, and dimedone in the presence of a catalytic amount of piperidine. A stepwise approach for the synthesis of the target compounds was also investigated.