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2000
Volume 11, Issue 6
  • ISSN: 1570-1794
  • E-ISSN: 1875-6271

Abstract

By an efficient biomimetic synthetic method, several novel 2-substituted benzimidazoles, benzoxazoles, and benzothiadazole were readily prepared in good yields under mild conditions with 2-substituted imidazolinium iodides as the tetrahydrofolate model compounds at the oxidation level of formate. The reaction is probably involved in a nucleophilic addition to the C=N bond at the imidazolinium ring, followed a 1,3-H migration at an imidazolidine intermediate and a salt elimination.

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/content/journals/cos/10.2174/1570179411666140708173654
2014-12-01
2025-06-13
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