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Volume 11, Issue 6
  • ISSN: 1570-1794
  • E-ISSN: 1875-6271

Abstract

The Barton-McCombie reaction (B-M reaction) is deoxygenation of aliphatic alcohols via thioacylation followed by a radical cleavage. Variations of the reactions may utilize different thioacyl fragments and hydrogen sources. In this review article, however, we have focused on the applications of this reaction as a mild and functional group tolerant method in deoxygenation step in total syntheses of some well recognized natural products.

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/content/journals/cos/10.2174/157017941106141023113539
2014-12-01
2025-05-25

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  • Article Type:     Research Article
Keyword(s): Barton-McCombie reaction; deoxygenation; free-radical reaction; hydroxyl group; natural product; tin hydrid; total syntheses; xanthate

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