Synthesis of a Common Tetrasaccharide Repeating Unit of the O-antigen of Enteroinvasive Escherichia coli O143 and Shigella boydii Type 8

A concise chemical synthesis of the common tetrasaccharide corresponding to the O-antigen of enteroinvasive Escherichia coli O143 and Shigella boydii type 8 has been achieved in excellent yield. Application of [2+2] block glycosylation and late stage oxidation of primary hydroxyl groups to the carboxylic groups are notable features in the synthetic strategy.