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- ISSN: 1570-1794
- E-ISSN: 1875-6271
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The Asymmetric [C+NC+CC] Coupling Reaction: Development and Application to Natural Product Synthesis
- Source: Current Organic Synthesis, Volume 7, Issue 4, Aug 2010, p. 348 - 362
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- 01 Aug 2010
Abstract
Development of the asymmetric [C+NC+CC] coupling reaction is described. This reaction assembles aldehyde (C), amine (NC), and alkene (CC) components in a predictable and controlled fashion to give highly functionalized pyrrolidines. The utility of the asymmetric [C+NC+CC] coupling reaction is demonstrated by its application to an efficient formal total synthesis of cyanocycline A.
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