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- ISSN: 1570-1794
- E-ISSN: 1875-6271
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Synthesis of Natural Products Using Intramolecular Dipolar Cycloaddition Reactions
- Source: Current Organic Synthesis, Volume 7, Issue 4, Aug 2010, p. 312 - 331
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- 01 Aug 2010
Abstract
This review describes ylide 1,3-dipoles in cycloaddition reactions for the synthesis (and formal synthesis) of natural products. Examples using azomethine ylides, carbonyl ylides, nitrones, nitronates, nitrile oxides and azides are provided. These lead to a diverse array of heterocyclic products. Intramolecular cycloaddition provides two new rings in one step and hence an efficient entry to complex target compounds.
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